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Norethindrone

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Definition: A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.     
Pharmacological Action Contraceptives, Oral, Synthetic 		Other names Norpregneninolone; Norethisterone; Ethinylnortestosterone; NorQD; Nor QD; Norlutin; Norethindrone, (1 beta)-Isomer; Norcolute; Norcolut; Nor-QD; Monogest; Micronor; ConceplanDrugs* : NORLESTRIN 21 1/50; MODICON 21; LOESTRIN 21 1/20; ORTHO-NOVUM 1/35-28; NORETHINDRONE AND ETHINYL ESTRADIOL (10/11); NORETHIN 1/35E-28; NORCEPT-E 1/35 28; NORTREL 1/35-21; NORETHINDRONE ACETATE AND ETHINYL ESTRADIOL AND FERROUS FUMARATE; NOR-QD; LOESTRIN FE 1/20; ORTHO-NOVUM 7/7/7-28; NORETHINDRONE AND ETHINYL ESTRADIOL (7/14); MICROGESTIN 1/20; JUNEL 1/20; PHILITH; NORETHIDRONE; ORTHO-NOVUM 10/11-21; ORTHO-NOVUM 7/14-21; ESTROSTEP FE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ovcon 35  0   *Ethinyl Estradiol *Norethindrone Drug Combinations. FDA Consum 2004 Mar-Apr;38(2):4FEMCON FE; OVCON-35
Org 4060  0   Norethindrone/*analogs & derivatives. Xenobiotica 2002 Feb;32(2):109-18
EVE 20 TM  0   Norethindrone/*analogs & derivatives. Contraception 2001 Oct;64(4):217-22
7-methyl-norethisterone  0   Norethindrone/*analogs & derivatives. J Steroid Biochem Mol Biol 2000 Nov 15;74(4):213-22
estradiol, norethindrone drug combination  0   *Estradiol *Norethindrone Drug Combinations. Przegl Lek 2000;57(7-8):397-401
Org 30659  0   Norethindrone/*analogs & derivatives. J Steroid Biochem Mol Biol 1995 Dec;55(3-4):423-37
norethisterone-3-oxime acetate  20799-24-0   Norethindrone/*analogs & derivatives. J Tongji Med Univ 1991;11(2):81-7
5,17-dihydroxy-5,17,19-norpregn-20-yn-3-one  101409-94-3   Norethindrone/*analogs & derivatives. Steroids 1988;51(5-6):459
norethisterone cholesterol  0   *Cholesterol *Norethindrone Drug Combinations Delayed-Action Preparations. Contraception 1988;37(4):349
10-fluoroethindrone  2796-89-6   Norethindrone/*analogs & derivatives Aromatase Inhibitors. Nippon Sanka Fujinka Gakkai Zasshi 1987;39(5):849
11-keto-delta-9-norethisterone  5210-27-5   Norethindrone/*analogs & derivatives. Yao Hsueh Hsueh Pao 1986;21(4):300
norethisterone acetate 3-cyclopentylpropionate  99112-29-5   Norethindrone/*analogs & derivatives. Yao Hsueh Hsueh Pao 1984;19(12):935
10-hydroperoxy-7-methylnorethindrone 17-heptanoate  93176-68-2 19-Norpregn-4-en-20-yn-3-one, 10-hydroperoxy-7-methoxy-17-((1-oxoheptyl)oxy)-, (7alpha,17alpha)  Norethindrone/*analogs & derivatives. Steroids 1983;42(4):401
norbiogest  51367-42-1   *Mestranol Norethindrone/*analogs & derivatives Contraceptives, Oral, Combined. Bratisl Lek Listy 1983;80(5):603
norethindrone isonicotinyl hydrazone  86762-75-6 4-Pyridinecarboxylic acid, ((17alpha)-17-hydroxy-19-norpregn-4-en-20-yn-3-ylidene)hydrazide  Norethindrone/*analogs & derivatives. J Pharm Sci 1983;72(9):1084
netagen  62057-27-6   *Estradiol *Norethindrone Contraceptives, Oral, Combined. Gynecol Obstet Invest 1983;15(5):275
1-acetoxy-17-ethinyl-17-hydroxy-18-methyl-4-estren-3-one  53020-96-5 18,19-Dinorpregn-4-en-20-yn-3-one, 1-(acetyloxy)-13-ethyl-17-hydroxy-, (1beta,17alpha)  Norethindrone/*analogs & derivatives. Contraception 1983;27(2):201
norlestrin  8015-12-1   *Ethinyl Estradiol Norethindrone/*analogs & derivatives Contraceptives, Oral, Combined. J Toxicol Environ Health 1982;10(6):879
10-acetoxy-17-hydroxy-17-ethinylestr-4-en-3-one  82683-45-2 Pregn-4-en-20-yn-3-one, 19-(acetyloxy)-17-hydroxy-, (17alpha)  Norethindrone/*analogs & derivatives. Yao Hsueh Hsueh Pao 1982;17(4):304
Trisequens  66100-41-2   *Estradiol *Estriol Drug Combinations Norethindrone/*analogs & derivatives.
Pharma Action Contraceptives, Oral 		Drug Ther Bull 1981;19(16):63
norethindrone enanthate  3836-23-5 (17 alpha)-17-((1-oxoheptyl)oxy)-19-norpregn-4-en-20-yn-3-one  Norethindrone/*analogs & derivatives Progesterone Congeners.
Pharma Action Contraceptive Agents, Female ; Contraceptives, Oral, Synthetic 		Fertil Steril 1980;33(3):267
norethindrone acetate  38673-38-0 (17 alpha)-17-(acetyloxy)-19-norpregn-4-en-20-yn-3-one  Norethindrone/*analogs & derivatives.
Pharma Action Contraceptives, Oral, Synthetic 		IARC Monogr Eval Carcinog Risk Chem Hum 1979;21:441; Indian J Med Res 1979;70:625; Tumori 1979;65(6):703NORLUTATE; AYGESTIN; NORETHINDRONE ACETATE
estradiol, norethisterone, testosterone drug combination  0 19-Norpregn-4-en-20-yn-3-one, 17-(acetyloxy)-, (17alpha)-, mixt. with (17beta)-17-hydroxyestra-1,3,5(10)-trien-3-yl benzoate, (17beta)-3-hydroxyestra-1,3,5(10)-trien-17-yl pentanoate and (17beta)-17-((1-oxoheptyl)oxy)androst-4-en-3-one  *Norethindrone Drug Combinations Estradiol/*analogs & derivatives Testosterone/*analogs & derivatives. Acta Endocrinolog 88(Suppl 216):119;1978; Med J Malaysia 30(3):223;1975
norethindrone pivalate  65445-09-2 19-Norpregn-4-en-20-yn-3-one, 17-(2,2-dimethyl-1-oxopropoxy)-, (17alpha)  Norethindrone/*analogs & derivatives. Steroids 1979;34(7):793
norethindrone-4 beta,5 beta-epoxide  51267-63-1 (4 beta,5 beta,17 alpha)-4,5-epoxy-17-hydroxy-19-nor pregn-20-yn-3-one  Norethindrone/*analogs & derivatives. Chem Biol Interact 29(1):103;1980
ethynylestradiol mixture with norethindrone  37270-71-6 (17 alpha)-17-hydroxy-19-norpregn-4-en-20-yn-3-one, mixture with (17 alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol  *Ethinyl Estradiol *Norethindrone.
Pharma Action Contraceptives, Oral, Combined ; Contraceptives, Oral, Hormonal ; Contraceptives, Oral, Sequential ; Contraceptives, Oral, Synthetic 		Br Med J 2(6042):1014;1976; Drug Ther Bull 12(14):55;1974; Nature 242(397):410;1973; Nord Med 90(3):67;l975; Obstet Gynecol 53(6):694;1979NORETHINDRONE ACETATE; ETHINYL ESTRADIOL; NORETHINDRONE; ETHINYL ESTRADIOL; ARANELLE; ALYACEN 777
norethindrone 3-(O-dimethylaminopropyl)oxime  66841-21-2   Norethindrone/*analogs & derivatives. J Med Chem 21(7):712;1978
norethisterone-3-oxime  23965-86-8   Norethindrone/*analogs & derivatives. J Steroid Biochem 9(3):229;1978
Norinyl  8015-29-0 17-alpha-Ethynyl-19-nortestosterone and ethynylestradiol 3-methyl ether  *Mestranol *Norethindrone.
Pharma Action Contraceptives, Oral, Combined 		Int J Gynecol Obstet 14(5):385;1977; Obstet Gynecol 50(2):227;1977ORTHO-NOVUM 1/50 21; NORINYL 1+50 21-DAY; NORINYL; NORINYL 1+80 28-DAY; NORINYL 1+80 21-DAY; NORETHIN 1/50M-28; ORTHO-NOVUM 1/80 28; NORETHINDRONE AND MESTRANOL; ORTHO-NOVUM 10-21; ORTHO-NOVUM 2-21; ORTHO-NOVUM 1/50 28; NORETHIN 1/50M-21; ORTHO-NOVUM 1/80 21; NORINYL 1+50 28-DAY
5 alpha-dihydronorethindrone  52-79-9   Norethindrone/*analogs & derivatives. Endocrinology 100(6):1579;1977
norethisterone-3-methoxime  58001-83-5   Norethindrone/*analogs & derivatives. Contraception 12(5):511;1975
Deposiston  54958-72-4   *Norethindrone Ethinyl Estradiol/*analogs & derivatives.
Pharma Action Contraceptives, Oral, Combined 		Dtsch Gesundheitswesen 30(33):1553;1975; Dtsch Gesundheitswesen 33(50):2373;1978NORLESTRIN FE 1/50; NORQUEST FE; NORLESTRIN FE 2.5/50
Non-Ovlon  57637-90-8   *Chlormadinone Acetate *Norethindrone.
Pharma Action Antineoplastic Agents ; Contraceptives, Oral, Combined ; Hemostatics 		Dtsch Gesundheitswes 29(10):470;1974
10 beta-hydroxy-19-norethisterone  1236-00-6 19-Norpregn-4-en-20-yn-3-one, 10,17-dihydroxy-, (17alpha)  Norethindrone/*analogs & derivatives. J Steroid Biochem 4(3):283;1973
U-13,851  7642-52-6 Pregn-4-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7alpha,17alpha)  Norethindrone/*analogs & derivatives. Contraception 1(2):87;1970

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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