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Pregnenolone

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Definition: A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.  do not confuse with PREGNANOLONE   
Examples 17-alpha-Hydroxypregnenolone; Pregnenolone Carbonitrile 		Other names 5 Pregnen 3 beta ol 20 one; 5-Pregnen-3-beta-ol-20-one
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-acetoxy-5,6-epoxy-16-pregnen-20-one  0   Pregnenolone/*analogs & derivatives. Andrologia 2009 Feb;41(1):29-34
3beta-methoxypregnenolone  0   Pregnenolone/*analogs & derivatives. Proc Natl Acad Sci U S A 2006 Mar 21;103(12):4711-6
7-dehydropregnenolone  0   Pregnenolone/*analogs & derivatives. Proc Natl Acad Sci U S A 2003 Dec 9;100(25):14754-9
16,17-epoxy-20-oxopregn-5-en-3-yl acetate  0   Pregnenolone/*analogs & derivatives. Acta Crystallogr C 2001 May;57(Pt 5):587-9
22-iminopregn-5-en-3-ol  0   *Imines Pregnenolone/*analogs & derivatives Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Med Chem 2000 Nov 16;43(23):4437-45
16-hydroxypregnenolone  0   Pregnenolone/*analogs & derivatives. Biol Pharm Bull 1999 Dec;22(12):1262-5
CCD 3693  177080-77-2   Pregnenolone/*analogs & derivatives. J Pharmacol Exp Ther 1997 Jul;282(1):420-9
pregnenolone 3-stearate  0   *Stearates Pregnenolone/*analogs & derivatives. J Chromatogr Sci 1997 Feb;35(2):71-4
pregnenolone-3-O-methylthiophosphonate  155538-87-7   Pregnenolone/*analogs & derivatives Arylsulfatases/antagonists & inhibitors. J Steroid Biochem Mol Biol 1994 Apr;48(5-6):523-7
esculentin steroid  131889-89-9 Pregn-5-en-20-one, 3-((O-6-deoxy-3-O-methyl-beta-D-glucopyranosyl-(1-4)-O-2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-3-O-methyl-beta-D-arabino-hexopyranosyl)oxy)-8,11,12,14,17-pentahydroxy-, (3beta,11alpha,12beta,14beta,17alpha)  *Glycosides Pregnenolone/*analogs & derivatives Coumarins. Biol Pharm Bull 1994 Aug;17(8):1018-22
hancoside A  145701-08-2   *Saponins Pregnenolone/*analogs & derivatives. Yao Hsueh Hsueh Pao 1992;27(8):595-602
pregnenolone 16-acetonitrile  102812-95-3   *Acetonitriles Pregnenolone/*analogs & derivatives. Eur J Drug Metab Pharmacokinet 1991;16(1):9
N-(4-iodophenyl)pregnenolone 3-carbamate  124824-12-0   Pregnenolone/*analogs & derivatives. Int J Rad Appl Instrum (B) 1989;16(6):603
pregnenolone 2,6-dimethyl-3-iodobenzoate  124784-16-3 Pregn-5-en-20-one, 3-((3-iodo-2,6-dimethylbenzoyl)oxy)-, (3beta)  Pregnenolone/*analogs & derivatives. Int J Rad Appl Instrum (B) 1989;16(6):603
21-chloropregnenolone  30459-98-4   Pregnenolone/*analogs & derivatives. Arch Biochem Biophys 1988;264(2):462
21,21-dichloropregnenolone  117038-60-5   Pregnenolone/*analogs & derivatives. Arch Biochem Biophys 1988;264(2):462
pregnenolone-naltrexone azine  108743-74-4   Naltrexone/*analogs & derivatives Pregnenolone/*analogs & derivatives. Natl Inst Drug Abuse Res Monogr Ser 1986;75:45
20-((2-trimethylsilyl)ethyl)pregn-5-en-3,20-diol  88703-32-6 24-Norchol-5-ene-3,20-diol, 23-(trimethylsilyl)-, (3beta)  *Trimethylsilyl Compounds Pregnenolone/*analogs & derivatives. J Biol Chem 1985;260(2):852
pregnenolone iopanoate  0   Iopanoic Acid/*analogs & derivatives Pregnenolone/*analogs & derivatives. J Comput Assist Tomogr 1984;8(6):1099
Metharmon F  92526-19-7 Androst-4-ene-3,17-dione, mixt. with (3beta,17beta)-androst-5-ene-3,17-diol, desiccated thyroid hormones, (17beta)-17-hydroxyandrost-4-en-3-one, 3-hydroxyestra-1,3,5(10)-trien-17-one and (3beta)-3-hydroxypregn-5-en-20-one  *Androstenedione *Estrone *Pregnenolone *Testosterone *Thyroid (USP) *Androstenediol Drug Combinations. Horumon To Rinsho 1983;31(8):815
20-(1,5-hexadiynyl)-5-pregnen-3,20-diol  86532-89-0 Pregn-5-ene-3,20-diol, 20-(1,5-hexadiynyl)-, (3beta,20R)  Pregnenolone/*analogs & derivatives Cholesterol Side-Chain Cleavage Enzyme/antagonists & inhibitors. J Biol Chem 1983;258(11):6721
20-(1-hexynyl)-5-pregnen-3,20-diol  86532-88-9 Pregn-5-ene-3,20-diol, 20-(1-hexynyl)-, (3beta,20R)  Pregnenolone/*analogs & derivatives Cholesterol Side-Chain Cleavage Enzyme/antagonists & inhibitors. J Biol Chem 1983;258(11):6721
20-(1-propynyl)-5-pregnen-3,20-diol  86562-07-4 Chol-5-en-22-yne-3,20-diol, (3beta)  Pregnenolone/*analogs & derivatives Cholesterol Side-Chain Cleavage Enzyme/antagonists & inhibitors. J Biol Chem 1983;258(11):6721
pregnenolone oleate  72205-39-1   Pregnenolone/*analogs & derivatives. J Steroid Biochem 1983;18(3):257
pregnenolone receptor  0   *Receptors, Glucocorticoid Pregnenolone. Biochim Biophys Acta 1983;755(1):40
3 beta,11 alpha,15 beta-trihydroxy-5-pregnen-20-one  78806-45-8 Pregn-5-en-20-one, 3,11,15-trihydroxy-, (3beta,11alpha,15beta)  Pregnenolone/*analogs & derivatives. Steroids 1981;37(3):291
16-pregnolone  566-61-0   *Pregnenolone Isomerism. J Steroid Biochem 1980;13(10):1181
pregnenolone sulfate  1247-64-9   *Pregnenolone. Biochemistry 17(21):4557;1978
16 alpha-isothiocyanopregnenolone-3-acetate  6084-04-4 3 beta-(acetyloxy)-16 alpha-isothiocyanatopregn- 5-en-20-one  Pregnenolone/*analogs & derivatives. Biokhimiia 43(7):1233;1978; Dokl Akad Nauk SSSR 245(2):474;1979; Vopr Med Khim 23(4):473;1977
tomatillidine  986-45-8 (3 beta,20S,21R)-21-(4,5-dihydro-4-methyl-3H- pyrrol-2-yl)-3-hydroxy-20-methylpregn-5-en-21-one  Pregnenolone/*analogs & derivatives. Chem Pharm Bull (Tokyo) 24(4):661;1976
5-pregnen-3 beta-ol  2862-58-0 (3 beta)-pregn-5-en-3-ol  Pregnenolone/*analogs & derivatives. J Biol Chem 251(11):3320;1976
compound 5.4  0   *Pregnenolone Isomerism. Tijdschr Diergeneeskd 101(2):83;1976
5-pregnene-3,20-diol  901-56-4 Pregn-5-ene-3,20-diol, (3beta,20S)  Pregnenolone/*analogs & derivatives. Gen Comp Endocrinol 24(4):352;1974; J Steroid Biochem 6:311;1975; J Steroid Biochem 7(4):289;1976
dehydropregnenolone acetate  979-02-2   Pregnenolone/*analogs & derivatives. Ark Patologii 37(6):45;1975; Gig Tr Prof Zabol 18(2):32;1974
16-dehydropregnenolone  1162-53-4 3 beta-hydroxypregna-5,16-dien-20-one  Pregnenolone/*analogs & derivatives. Biochim Biophys Acta 296(1):179;1973
17 alpha-hydroperoxypregnenolone  34069-59-5 (3beta)-17-hydroperoxy-3-hydroxypregn-5-en-20-one  Pregnenolone/*analogs & derivatives. Arch Biochem Biophys 153(2):495;1972; Steroidologia 2(2):65;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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