encyclopedia of medical concepts
ψ
ψ
Biotin
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Definition
: A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
/ther use: coordinate disease with /drug ther, not /diet ther; deficiency: coordinate BIOTIN /defic (IM) with VITAMIN B DEFICIENCY (IM)
Pharmacological Action
Vitamin B Complex
See Also
Avidin
;
Biotinidase Deficiency
;
Holocarboxylase Synthetase Deficiency
;
Multiple Carboxylase Deficiency
Other names
Vitamin H; Roche, Biotine; Hermes, Biotin; H, Vitamin; Gelfert, Biotin; Biotinratiopharm; Biotin ratiopharm Brand; Biotin ratiopharm; Biotin Ziethen Brand; Biotin Strathmann Brand; Biotin Simons Brand; Biotin Roche Brand; Biotin Medopharm Brand; Biotin Hermes Brand; Biotin Dermapharm Brand; Biotin Biocur Brand; ratiopharm Brand of Biotin; medobiotin; e+b Pharma Brand of Biotin; Ziethen Brand of Biotin
Substance
CAS Registry & name
Categories
Source
Drugs
*
CH5164840
0
*Benzoquinones
*Lactams, Macrocyclic
Biotin
HSP90 Heat-Shock Proteins/antagonists & inhibitors.
Cancer Sci. 2012 Feb;103(2):342-9
3-
(iodobenzoyl)norbiotinamide-
PTD-
ODD-
SAV fusion protein
0
*Recombinant Fusion Proteins
Biotin/*analogs & derivatives
Iodine Radioisotopes.
Cancer Sci. 2011 Nov;102(11):2090-6.
(4,7-
bis-
carboxymethyl-
10-
(1-
(2-
(5-
(2-
oxohexahydrothieno(3,4-
d)imidazol-
6-
yl)-
pentanoylamino)ethyl)-
1H-
(1,2,3)triazol-
4-
ylmethyl)-
1,4,7,10-
tetraazacyclododec-
1-
yl)acetic acid
0
*Heterocyclic Compounds, 1-Ring
Biotin/*analogs & derivatives
Ligands.
J Drug Target 2011 Jul;19(6):418-26
EP 224283
0
*Oligosaccharides
Biotin/*analogs & derivatives
Factor XI/antagonists & inhibitors
Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors.
J Pharmacol Exp Ther 2011 Aug;338(2):412-20
biotinyl-
1(1-
pyrene)methylamide
0
*Pyrenes
Biotin/*analogs & derivatives.
J Photochem Photobiol B 2011 Jun 2;103(3):251-5
cyanurbiotindipropionylsuccinimide
0
*Succinimides
Biotin/*analogs & derivatives
Cross-Linking Reagents.
Mol Cell Proteomics 2011 Feb;10(2):M110.001420
DFK 1012
0
Acetylglucosamine/*analogs & derivatives
Biotin/*analogs & derivatives.
J Biol Chem 2011 Feb 18;286(7):5727-35
N-
(6-
(4-
(5-
(((5-
chloro-
3-
methyl-
1-
benzothien-
2-
yl)sulfonyl)amino)-
2-
methoxyphenyl)piperazin-
1-
yl)hexyl)-
5-
(-
2-
oxohexahydro-
1H-
thieno(3,4-
d)imidazol-
4-
yl)pentanamide
0
*Piperazines
Biotin/*analogs & derivatives
Ligands
Receptors, Serotonin.
J Med Chem 2010 Oct 14;53(19):7095-106
ACM-
14 peptide
0
*Peptides
Biotin/*analogs & derivatives.
Anticancer Res 2010 Jun;30(6):1887-95
EP 217609
0
*Oligosaccharides
Biotin/*analogs & derivatives.
Thromb Haemost 2009 Nov;102(5):804-11
N-
9-
oxo-
15-
hydroxyprosta-
10,13-
dien-
1-
oyl-
N-
biotinoyl-
1,6-
diaminohexane
0
*Prostaglandins A
Biotin/*analogs & derivatives.
Chem Biol Interact 2010 Jan 5;183(1):212-21
idrabiotaparinux
0
*Oligosaccharides
Biotin/*analogs & derivatives.
Semin Thromb Hemost 2009 Jul;35(5):515-24
biotin-
geranylpyrophosphate
0
*Polyisoprenyl Phosphates
Biotin/*analogs & derivatives.
Nat Chem Biol 2009 Apr;5(4):227-35
biotinylated linoleoylglycerylphosphatidylcholine
0
*Biotin
*Phosphatidylcholines.
J Proteome Res 2008 Oct;7(10):4237-46
B 10330
0
Biotin/*analogs & derivatives
Bradykinin/*analogs & derivatives.
Peptides 2008 Sep;29(9):1626-30
trifluoroacetyl(alpha,alpha-
diethyl)Gly-
Lys(Nepsilonbiotin)-
(D)Lys-
Cys
0
*Oligopeptides
Biotin/*analogs & derivatives.
Anal Chem 2007 Mar 1;79(5):1932-8
DPPB compound
0
*Phosphatidylcholines
Biotin/*analogs & derivatives.
Chem Res Toxicol. 2007 Feb;20(2):227-34
PLPB compound
0
*Phosphatidylcholines
Biotin/*analogs & derivatives.
Chem Res Toxicol. 2007 Feb;20(2):227-34
N'-
aminooxymethylcarbonylhydrazino D-
biotin
0
*Hydrazines
Biotin/*analogs & derivatives.
Anal Chem. 2006 Oct 1;78(19):6847-54
iminobiotin
0
Biotin/*analogs & derivatives.
Anal Sci. 2005 Aug;21(8):897-900
biotinylcysteic acid
0
Biotin/*analogs & derivatives
Cysteic Acid/*analogs & derivatives.
Anal Chem 2005 Jan 15;77(2):645-51
rhenium(I) amidodipyridoquinoxaline biotin
0
*Organometallic Compounds
Biotin/*analogs & derivatives
Rhenium.
Inorg Chem. 2006 Feb 20;45(4):1714-22
biotin-
BSA-
GdDTPA
0
*Biotin
*Pentetic Acid
*Serum Albumin, Bovine.
Magn Reson Med 2006 May;55(5):1013-22
hydroxysuccinimidyl-
poly(ethylene glycol)-
biotin
0
*Polyethylene Glycols
Biotin/*analogs & derivatives.
J Control Release 2006 Mar 10;111(1-2):135-44
z-
VK(biotin)D(OMe)-
fmk
0
*Dipeptides
Biotin/*analogs & derivatives.
Anal Biochem. 2006 Mar 1;350(1):32-40
2-
(biotinamido)ethanethiol
0
Biotin/*analogs & derivatives
Cysteamine/*analogs & derivatives.
Colloids Surf B Biointerfaces 2006 Jan 15;47(1):107-11
dibiotinylated aluminum sulfophthalocyanine
0
*Indoles
Biotin/*analogs & derivatives.
J Photochem Photobiol B 2005 Jul 1;80(1):57-64
diphenyl 4-
amidino-
alpha-
(biotinyl-
6-
aminohexanamido)benzylphosphonate
0
*Phosphonic Acids
Biotin/*analogs & derivatives.
J Mol Recognit 2005 Jul-Aug;18(4):295-306
9-
(2-
biotinylamidoethyl)carboxylate-
10-
methylacridinium
0
*Acridines
Biotin/*analogs & derivatives.
Clin Chim Acta 2005 Jul 24;357(2):159-67
9-
(2-
biotinyloxyethyl)carboxylate-
10-
methylacridinium
0
*Acridines
Biotin/*analogs & derivatives.
Clin Chim Acta 2005 Jul 24;357(2):159-67
biotinylated hen's egg sialyl glycopeptide
0
*Oligosaccharides
Biotin/*analogs & derivatives.
Chem Commun (Camb) 2004 Dec 7;(23):2692-3
4-
(3-
(biotinamido)propynyl)-
2-
oxo(1H)pyridin-
3-
ylribofuranosyl triphosphate
0
*Nucleosides
Biotin/*analogs & derivatives.
Nucleic Acids Res 2005;33(15):e129
rhodamin-
biotin distearylphosphatidylethanolamine
0
*Phosphatidylethanolamines
*Rhodamines
Biotin/*analogs & derivatives.
Chem Phys Lipids 2005 Feb;133(2):215-23
N-
(6-
(biotinamido)hexyl)-
3'-
(2'-
pyridyldithio)propionamide
0
*Disulfides
Biotin/*analogs & derivatives.
Biochem Biophys Res Commun 2005 May 20;330(4):1224-9
biotinylated sulfo-
Lewis A derivatized polyacrylamide
0
*Acrylamides
Biotin/*analogs & derivatives.
Circulation 2005 Jan 4;111(1):106-12
biotin-
phosmidosine (O-
ethyl ester) conjugate
0
*Biotin
*Purine Nucleotides.
Bioorg Med Chem 2004 Dec 15;12(24):6343-9
5-
(3-
(1-
(5-
(5-
(biotinylamino)pentanamidomethyl)-
2-
nitrophenyl)ethoxycarbonylamino)propenyl)-
2'-
deoxyuracil 5'-
triphosphate
0
*Deoxyuracil Nucleotides
Biotin/*analogs & derivatives.
Nucleic Acids Res 2004;32(2):535-41
N-
(13-
biotinamido-
4,7,10-
trioxatridecanyl) tert-
butyloxy carbamide
0
*Carbamates
Biotin/*analogs & derivatives.
Bioconjug Chem 2004 Jan-Feb;15(1):224-30
biotinyl-
3,6,9-
trioxaundecanediamine
0
Biotin/*analogs & derivatives.
J Pharm Sci 2003 May;92(5):933-7
1-
biotinamido-
4-
(4'-
(maleimidomethyl)cyclohexanecarboxamido)butane
0
Biotin/*analogs & derivatives.
Prostaglandins Leukot Essent Fatty Acids 2003 Apr;68(4);273-84
technetium 99m DTPA-
bisbiotin
0
*Organotechnetium Compounds
Biotin/*analogs & derivatives.
Nucl Med Biol 2003 Feb;30(2):135-40
copper-
64-
DOTA-
biotin
0
*Organometallic Compounds
Biotin/*analogs & derivatives
Copper Radioisotopes.
J Nucl Med 2003 Aug;44(8):1284-92
diaminobiotin
0
Biotin/*analogs & derivatives.
J Nutr. 2003 May;133(5):1259-64
streptaphage
0
Biotin/*analogs & derivatives
Cholesterol/*analogs & derivatives.
J Am Chem Soc 2002 Jun 5;124(22):6265-73
oxybiotin
0
Biotin/*analogs & derivatives.
Carbohydr Res 2002 Mar 1;337(5):459-65
TBL(4)K compound
0
*Azirines
Biotin/*analogs & derivatives.
Science 2002 Jun 21;296(5576):2215-8
6-
biotin-
17-
nicotinamide-
adenine-
dinucleotide
0
Biotin/*analogs & derivatives
NAD/*analogs & derivatives.
J Histochem Cytochem 2002 Jan;50(1):91-8
N-
(5-
azido-
2-
nitrobenzoyl)-
N'-
biotinyl-
1,2-
diaminoethane
0
Biotin/*analogs & derivatives.
J Photochem Photobiol B 2001 Aug 15;61(1-2):68-77
8-
N(3)-
3'-
biotinyl-
ATP
0
Adenosine Triphosphate/*analogs & derivatives
Biotin/*analogs & derivatives.
Biochem Biophys Res Commun 2001 Sep 7;286(5):1218-27
NEPP6-
biotin
0
*Prostaglandins
Biotin/*analogs & derivatives.
J Neurochem 2001 Apr;77(1):50-62
RP 488
0
*Organotechnetium Compounds
Biotin/*analogs & derivatives.
Nucl Med Biol 2000 Nov;27(8):803-13
N-
biotinylaminoethyl methanethiosulfonate
0
Biotin/*analogs & derivatives.
J Neurosci 2001 Jan 1;21(1):67-74
biotin-
aminohexylamino-
glycyl-
glycyl-
leucyl-
epoxysuccinyl-
leucyl-
proline
0
*Oligopeptides
Biotin/*analogs & derivatives
Affinity Labels.
biotin-
tyrosyl-
valyl-
alanyl-
aspartic acid aldehyde
0
*Oligopeptides
Biotin/*analogs & derivatives.
J Leukoc Biol 2000 Jul;68(1):87-96
biotin methyl ester
608-16-2
Biotin/*analogs & derivatives.
Anal Chem 2000 Jun 1;72(11):2418-22
4-
(2-
(2-
(2-
(biotinylamino)ethoxy)ethoxy)ethoxy)aminocarbonyl-
2-
diphenylphosphinobenzoic acid
0
*Phosphines
Biotin/*analogs & derivatives.
Science 2000 Mar 17;287(5460):2007-10
DOTA-
biotin
0
*Organometallic Compounds
Biotin/*analogs & derivatives
Yttrium Radioisotopes.
Clin Cancer Res 2000 Feb;6(2):406-14
N-
(((6-
biotinoyl)amino)hexanoyl)-
1,2-
dihexadecanoyl-
sn-
glycero-