Definition: A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Other names Nu Sulindac; Nu Pharm Brand of Sulindac; Novo Sundac; MK231; MK 231; Apo Sulin; Sulindal; Nu-Sulindac; Nu-Pharm Brand of Sulindac; Novopharm Brand of Sulindac; Novo-Sundac; Merck Sharp & Dohme Brand of Sulindac; Merck Brand of Sulindac; MK-231; Klinoril; Kendrick Brand of Sulindac; Kenalin; Copal; Clinoril; Chibret
sulindac sulfone [ (5-fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-(N-benzyl)-indene)-acetamide,1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfonyl)phenyl)methylene)-, (Z)-,Aptosyn,CP 248,CP248,FGN-1,OSIP 486823,OSIP-486823,OSIP486823,exisulind,sulindac sulfone, (Z)-isomer ] inhibits K-ras-dependent cyclooxygenase-2; sulfated analog of indomethacin;; CP248 is an antineoplastic agent that fosters microtubule depolymerization; structure in first source
