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Integrin alpha4beta1

More information in Books or onNLM PubMed
Definition: Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.      Other names Integrin Heterodimer alpha4beta1; CD49d-CD29; alpha4beta1, Integrin Heterodimer; alpha4beta1, Integrin; Very Late Antigen 4; Very Late Activation Antigen 4; Late Antigen-4, Very; Integrin, alpha4beta1; Heterodimer alpha4beta1, Integrin; Antigen-4, Very Late; alpha4beta1 Integrin; Very Late Antigen-4; Very Late Activation Antigen-4; VLA-4; Integrin alpha(4)beta(1)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-((2,6-dichlorophenyl)carbonylamino)-3-((2,4,8-triaza-2-methyl-1-oxo-4-phenylspiro(4.5)dec-8-yl)carbonylamino)propanoic acid  0   *Spiro Compounds beta-Alanine/*analogs & derivatives Integrin alpha4beta1/antagonists & inhibitors. J Pharm Sci 2010 Sep;99(9):3986-4004
3-(1,3-benzodioxol-5-yl)-3-((((-1-((bis(2-thienylmethyl)amino)carbonyl)pentyl)amino)carbonyl)amino)propanoic acid  0   *Thiophenes Urea/*analogs & derivatives Integrin alpha4beta1/antagonists & inhibitors. Biochem Biophys Res Commun 2010 Oct 1;400(4):619-24
4-((2-(2-methylphenylamino)-6-benzoxazolylacetyl)-4-fluoro-2-pyrrolidinylmethoxy)cyclohexanecarboxylic acid  0   *Benzoxazoles *Cyclohexanecarboxylic Acids Integrin alpha4beta1/antagonists & inhibitors. Bioorg Med Chem 2009 Feb 1;17(3):1232-43
4-(1-(3-chloro-4-(N-(2-methylphenyl)ureido)phenylacetyl)-4-fluoropyrrolidine-2-yl)methoxybenzoic acid  0   *Phenylurea Compounds *Pyrrolidines Integrin alpha4beta1/antagonists & inhibitors. J Pharmacol Exp Ther 2007 Jan;320(1):124-32
S 16197  0   *Amino Acids *Phenylurea Compounds Integrin alpha4beta1/antagonists & inhibitors. J Immunol 2005 Oct 1;175(7):4724-34
S 18407  0   *Imidazoles *Phenylurea Compounds Integrin alpha4beta1/antagonists & inhibitors. J Immunol 2005 Oct 1;175(7):4724-34
S 3429  0   *Hydantoins *Phenylurea Compounds Integrin alpha4beta1/antagonists & inhibitors. J Heart Lung Transplant 2004 Nov;23(11):1266-76
IVL 984  0   *Phenylurea Compounds Phenylalanine/*analogs & derivatives Integrin alpha4beta1/antagonists & inhibitors. Birth Defects Res Part B Dev Reprod Toxicol 2004 Apr;71(2):55-69
3-(N-(3,4-dimethoxybenzyl)-2-(2-(3-methoxy-4-(3-o-tolylureido)phenyl)acetylamino)acetamido)propanoic acid  0   *Propionic Acids Integrin alpha4beta1/antagonists & inhibitors. J Clin Pharmacol. 2004 Apr;44(4):348-58

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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