|
| An enzyme found predominantly in platelet microsomes. It catalyzes the conversion of PGG(2) and PGH(2) (prostaglandin endoperoxides) to thromboxane A2. EC 5.3.99.5.
| found in platelet microsomes
| Other names Thromboxane Synthetase; Synthetase, Thromboxane A2; Synthetase, Thromboxane; Synthase, Thromboxane-A; Synthase, Thromboxane A; A2 Synthetase, Thromboxane; Thromboxane A2 Synthetase; Thromboxane A Synthase; Thromboxane Synthetase
| |
| Substance | CAS Registry & name | Categories | Source | Drugs*
|
| imidazole
| 288-32-4
|
*Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
|
Prostaglandins 1981;21(3):401
|
| ozagrel
| 82571-53-7
2-Propenoic acid, 3-(4-(1H-imidazol-1-ylmethyl)phenyl)-, (E)
*Methacrylates Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Fibrinolytic Agents ; Histamine Antagonists
|
Jpn Heart J 1981;22(6):971
|
| dazoxiben
| 78218-09-4
Benzoic acid, 4-(2-(1H-imidazol-1-yl)ethoxy)
*Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
|
Lancet 1981;1(8221):629
|
| dazmegrel
| 76894-77-4
1H-Indole-1-propanoic acid, 3-(1H-imidazol-1-ylmethyl)-2-methyl
*Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Platelet Aggregation Inhibitors ; Vasodilator Agents
|
Circulation 1983;68(4):821
|
2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid
75987-08-5
2-propenoic acid, 2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-,
*Methacrylates Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
|
Eur J Pharmacol 1981;69(4):533; No To Shinkei 1981;33(11):1147
|
| furegrelate
| 85666-17-7
|
*Benzofurans Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
|
Prostaglandins 1983;26(2):311
|
| ridogrel
| 110140-89-1
Pentanoic acid, 5-(((3-pyridinyl(3-(trifluoromethyl)phenyl)methylene)amino)oxy)-, (E)
*Pentanoic Acids *Pyridines Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Gastrointestinal Agents ; Platelet Aggregation Inhibitors
|
Thromb Haemost 1989;61(1):35
|
| pirmagrel
| 85691-74-3
Imidazo(1,5-a)pyridine-5-hexanoic acid
*Imidazoles *Pyridines Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Immunosuppressive Agents
|
Biochem Biophys Res Commun 1983;112(3):899
|
| nafagrel
| 97901-21-8
|
*Imidazoles *Tetrahydronaphthalenes Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
|
J Chromatogr 1988;426(1):111
|
3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid
87627-28-9
1H-Indole-1-octanoic acid, 3-methyl-2-(3-pyridinyl)
*Pyridines Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Uricosuric Agents
|
Br J Pharmacol 1985;86(2):497
|
| isbogrel
| 89667-40-3
6-Heptenoic acid, 7-phenyl-7-(3-pyridinyl)-, (E)
*Fatty Acids, Monounsaturated *Pyridines Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Fibrinolytic Agents
|
Eur J Pharmacol 1985;109(2):135
|
| Y 20811
| 104363-98-6
Benzoic acid, 4-(hydroxy(5-(1H-imidazol-1-yl)-2-methylphenyl)methyl)-3,5-dimethyl-, monosodium salt
*Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Fibrinolytic Agents
|
Thromb Res 1986;43(4):455
|
| RS 5186
| 113817-57-5
Benzo(b)thiophene-6-carboxylic acid, 4,5-dihydro-2-(1H-imidazol-1-ylmethyl)-, sodium salt
*Thiophenes Thromboxane-A Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Platelet Aggregation Inhibitors ; Neuroprotective Agents
|
Arzneimittelforschung 1988;38(2):224
|
| E 3040
| 145096-30-6
|
*Pyridines *Benzothiazoles Thromboxane-A Synthase/antagonists & inhibitors.
|
J Pharmacol Exp Ther 1995 Sep;274(3):1362-9
|
| rolafagrel
| 89781-55-5
|
*Imidazoles *Naphthalenes Thromboxane-A Synthase/antagonists & inhibitors.
|
Kidney Int 1990;38(3):447
|
| N 0164
| 60787-00-0
(phenylmethyl)phosphonic acid, mono(4-(2-((4-chlorophenyl)methyl)-1-oxo-3-phenylpropyl)phenyl) ester, sodium salt
|
*Phosphonic Acids Thromboxane-A Synthase/antagonists & inhibitors.
|
Biochim Biophys Acta 531(3):286;1978; Br J Pharmacol 58:333;1976; Br J Pharmacol 60(2):293P;1977; Br J Pharmacol 60:135;1977; J Endocrinol 75(2):335;1977; Prostaglandins 12(3):465;1976; Prostaglandins 14(5):897;1977; Prostaglandins 16(3):373;1978; Thromb Res 11:705;1977; Urology 12(6):674;1978
|
1-(2,3-bis((4-methoxyphenyl)methoxy)propyl)-1H-imidazole
84750-41-4
1H-Imidazole, 1-(2,3-bis((4-methoxyphenyl)methoxy)propyl)
|
*Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
|
Thromb Res 1987;46(4):555
|
6-(5-methylimidazol-1-yl)methyl-2-naphthoic acid hydrochloride
| 105523-24-8
|
*Imidazoles *Naphthalenes Thromboxane-A Synthase/antagonists & inhibitors.
|
Biomed Biochim Acta 1988;47(10-11):S23
|
| CV 6504
| 117574-40-0
|
*Benzoquinones Thromboxane-A Synthase/antagonists & inhibitors.
|
Adv Prostaglandin Thromboxane Leukotriene Res 1991;21A:173
|
| CGS 22652
| 134235-78-2
|
*Octanoic Acids *Sulfonamides Thromboxane-A Synthase/antagonists & inhibitors.
|
J Med Chem 1992 Nov 13;35(23):4373-83
|
| camonagrel
| 105920-77-2
|
*Indans Thromboxane-A Synthase/antagonists & inhibitors.
|
Methods Fin Exp Clin Pharmacol 1996 Apr;167-74
|
| cinnamophilin
| 154677-96-0
|
*Lignans Guaiacol/*analogs & derivatives Thromboxane-A Synthase/antagonists & inhibitors.
|
Br J Pharmacol 1994 Mar;111(3):906-12
|
| UK 34787
| 72818-36-1
1H-indole, 3-(1H-imidazol-1-ylmethyl)-2-(1-methylethyl)
|
*Indoles Thromboxane-A Synthase/antagonists & inhibitors.
|
Thromb Res 1980;20(2):219
|
1-carboxyheptylimidazole
| 68887-68-3
|
*Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
|
Thromb Res 1981;21(4-):413
|
Ro 22-3581
| 10041-06-2
|
*Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
|
Prostaglandins 1982;23(1):273
|
Ro 22-4679
86003-82-9
Ro 22-4679
|
*Imidazoles Thromboxane-A Synthase/antagonists & inhibitors.
|
Circ Res 1983;52(5):608
|
| DTTX30
| 0
|
*Chlorobenzenes *Pyridines Thromboxane-A Synthase/antagonists & inhibitors Receptors, Thromboxane/antagonists & inhibitors.
|
Basic Res Cardiol 1997 Jun;92(3):181-90
|
3-carbamyl-(3'-picolyl)-4-methoxy-1-benzamide
108828-56-4
1,3-Benzenedicarboxamide, 4-methoxy-N3-(3-pyridinylmethyl)
|
*Benzamides *Picolines Thromboxane-A Synthase/antagonists & inhibitors.
|
J Cardiovasc Pharmacol 1992 Jan;19(1):60-8
|
| ICI D1542
| 147332-48-7
4-Hexenoic acid, 6-(2-(1-methyl-1-(4-methyl-2-nitrophenoxy)ethyl)-4-(3-pyridinyl)-1,3-dioxan-5-yl)-, (2S-(2alpha,4alpha,5alpha(Z)))
|
*Dioxanes *Pyridines Thromboxane-A Synthase/antagonists & inhibitors.
|
Br J Pharmacol 1993 Apr;108(4):901-6
|
| KDI 792
| 0
|
*Pyridines *Pyrrolidines Thromboxane A2/antagonists & inhibitors Thromboxane-A Synthase/antagonists & inhibitors.
|
Prostaglandins Leukot Essent Fatty Acids 1995 Aug;53(2):139-45
|
| Troeger's base
| 529-81-7
|
*Azocines Thromboxane-A Synthase/antagonists & inhibitors.
|
J Med Chem Oct 15;36(21):3202-6
|
LG 82-4-00
91505-18-9
2-Thiophenecarboxylic acid, 5-(2-(1H-imidazol-1-yl)ethoxy)-, monohydrochloride
|
*Thiophenes Thromboxane-A Synthase/antagonists & inhibitors.
|
Eur J Pharmacol 1985;112(2):161
|
5-chloro-1-methyl-2-(3-pyridyl)-3-indolehexanoic acid
107190-22-7
1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-, monohydrochloride
|
*Indoles Thromboxane-A Synthase/antagonists & inhibitors.
|
Eur J Pharmacol 1987;133(3):265
|
2-(2-dimethylaminoethyl)-5-benzylidene-6-methyl-3-pyridazinone
| 117027-28-8
|
*Benzyl Compounds *Pyridazines Thromboxane-A Synthase/antagonists & inhibitors.
|
Prostaglandins Leukot Essent Fatty Acids 1988;33(2):143
|
| Wy 27569
| 103417-69-2
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-(1H-imidazol-1-ylmethyl)-6-methyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl ester
| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |