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Pepstatins

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Definition: N-acylated oligopeptides isolated from culture filtrates of Actinomycetes, which act specifically to inhibit acid proteases such as pepsin and renin.  protease inhib   
Pharmacological Action Protease Inhibitors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BODIPY FL-pepstatin A  0   *Boron Compounds *Pepstatins. J Biochem Biophys Methods 2000 Mar 16;42(3):137-51
N-pepstatinyl-N'-dansyldiaminopropane  0   *Dansyl Compounds *Pepstatins. J Biochem (Tokyo) 1997 Aug;122(2):294-9
tert-Boc-valyl-(3-hydroxy-4-amino-5-(2-naphthyl)pentanoyl)-alanylisoamylamide  100994-43-2   *Naphthalenes *Pepstatins. Biochemistry 1986;25(8):1858
pepstatin ketone analog  81485-13-4   *Pepstatins. Biochem Biophys Res Commun 1985;129(2):597
lactoylpepstatin  82867-32-1 Pepstatin A, 1-(N-(2-hydroxy-1-oxopropyl)-L-valine)  *Pepstatins. Biochem J 1982;203(3):795
pepstatyl, Gly-Lys-Lys  83487-84-7 L-Lysine, N2-(N2-(N-(3-hydroxy-4-((2-((3-hydroxy-6-methyl-4-((N-(N-(3-methyl-1-oxobutyl)-L-valyl)-L-valyl)amino)-1-oxoheptyl)amino)-1-oxopropyl)amino)-6-methyl-1-oxoheptyl)glycyl)-L-lysyl)-, stereoisomer  *Pepstatins. Biosci Rep 1982;2(6):427
pepsinostreptin  51724-57-3   *Pepstatins. Anal Biochem 1982;122(2):308
N-pepstatinyl-S-bimanyl-2-aminoethanethiol  80562-33-0 Pepstatin A, 5-((3S,4S)-3-hydroxy-6-methyl-N-(2-(((2,5,6-trimethyl-1,7-dioxo-1H,7H-pyrazolo(1,2-a)pyrazol-3-yl)methyl)thio)ethyl)-4-aminoheptanamide)  *Pepstatins. Biochem J 1981;199(3):611
pepstatin  39324-30-6   *Pepstatins HIV Protease Inhibitors.
Pharma Action Antimalarials ; Protease Inhibitors 		FEBS Lett 1981;128(1):63
pepstatyl, Asp-Arg  80318-70-3 Pepstatin A, 5a-L-aspartic acid-5b-(N5-(imino(nitroamino)methyl)-L-ornithine)-, bis(phenylmethyl) ester  *Pepstatins Renin/antagonists & inhibitors. Biochem J 1981;197(3):465
pepstatyl, Asp  70706-88-6 Pepstatin A, 5a-L-aspartic acid  *Pepstatins Renin/antagonists & inhibitors. Biochem J 1981;197(3):465
pepstatyl, Glu  70706-87-5 Pepstatin A, 5a-L-glutamic acid  *Pepstatins Renin/antagonists & inhibitors. Biochem J 1981;197(3):465
pepstatyl-arginine methyl ester  70706-82-0 Pepstatin A, 5a-L-arginine-, methyl ester  *Pepstatins Renin/antagonists & inhibitors. Biochem J 1981;197(3):465; J Cardiovasc Pharmacol 1980;2(5):687
Streptomyces pepsin inhibitor  11076-29-2   *Pepstatins Pepsin A/antagonists & inhibitors Hydroxyl Radical Proteinase Inhibitory Proteins, Secretory. Biochim Biophys Acta 452(2):521;1976; J Biochem (Tokyo) 1980;87(2):573
hydroxypepstatin  52329-53-0   *Pepstatins. Proteases Biol Control W3 C162N:439;1975
pepstanone A  38752-31-7   *Pepstatins Pepsin A/antagonists & inhibitors. J Antibiot 25(8):489;1972; Proteases Biol Control W3 C162N:439;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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