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| Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates. Phospholipase A1(EC 3.1.1.32) hydrolyzes the acyl group attached to the 1-position and phospholipase A2 (EC 3.1.1.4) hydrolyzes the acyl group attached to the 2-position.
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| Other names Phospholipase A2; Phospholipase A1; Lecithinase A2; Lecithinase A1; A2, Phospholipase; Phosphatidate 1 Acylhydrolase; A2, Lecithinase; A1, Phospholipase; A1, Lecithinase; A, Phospholipases; 1-Acylhydrolase, Phosphatidate; Phosphatidate 1-Acylhydrolase; Phospholipase A2; Phospholipase A1; Lecithinase A2; Lecithinase A1
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| Substance | CAS Registry & name | Categories | Source | Drugs*
|
| wortmannin
| 19545-26-7
(1 alpha,11 alpha)-11-(acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan- 3,7,17-trione
*Androstadienes Mycotoxins Phospholipases A/antagonists & inhibitors Potassium Channels/antagonists & inhibitors 1-Phosphatidylinositol 3-Kinase/antagonists & inhibitors.
Pharma Action Antibiotics, Antifungal ; Immunosuppressive Agents ; Insulin Antagonists ; Phosphodiesterase Inhibitors ; Radiation-Sensitizing Agents ; Serotonin Antagonists ; Protein Kinase Inhibitors
|
Helv Chim Acta 56(1):2901;1973; J Chem Soc Perkin I 2892;1972
|
Clara cell-specific protein
| 0
|
*Uteroglobin Enzyme Inhibitors Phospholipases A/antagonists & inhibitors.
|
Pediatr Res 1986;20(8):802
|
| group II secretory phospholipase A2
| EC 3.1.-
|
*Phospholipases A.
|
Cancer Res 1998 Feb 1;58(3):500-3
|
| dodecylphosphocholine
| 53949-18-1
ethanaminium, 2-(((dodecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, chloride
Phosphorylcholine/*analogs & derivatives Phospholipases A/antagonists & inhibitors.
Pharma Action Phosphodiesterase Inhibitors
|
Biochim Biophys Acta 1980;603(2):298
|
| surfactin peptide
| 24730-31-2
|
*Peptides, Cyclic Lipoproteins Phospholipases A/antagonists & inhibitors Surface-Active Agents.
Pharma Action Antibiotics, Antineoplastic ; Antiviral Agents ; Enzyme Inhibitors
|
Chem Pharm Bull (Tokyo) 22(4):938;1974
|
phospholipase A2-II
| EC 3.1.-
|
*Phospholipases A Crotalid Venoms Agkistrodon.
|
Int J Biochem 1994 Jan;26(1):43-8
|
phospholipase A2-alpha
| EC 3.1.1.-
|
Isoenzymes *Phospholipases A.
|
J Biol Chem 2000 Jan 14;275(2):1161-8
|
calcium-independent phospholipase A2
| EC 3.1.1.-
|
*Phospholipases A.
|
J Biol Chem 1997 Apr 25;272(17):11118-27
|
| heliodermin
| 89468-62-2
Helospectin I, 5-L-isoleucine-8-L-glutamine-9-L-glutamine-24-L-alanine-30-L-arginine-34-de-L-arginine-36-L-prolinamide-37-de-L-serine-38-de-L-serine
*Peptides Phospholipases A/antagonists & inhibitors Venoms Glucagon-Like Peptide 1.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Enzyme Inhibitors
|
FEBS Lett 1984;166(2):273
|
| manoalide
| 75088-80-1
|
*Terpenes Phospholipases A/antagonists & inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Anti-Bacterial Agents ; Calcium Channel Blockers ; Phosphodiesterase Inhibitors
|
J Biol Chem 1985;260(12):7234
|
phospholipase A2-activating protein
| 0
|
*Proteins Enzyme Activation Phospholipases A.
Pharma Action Enzyme Activators
|
Biochem J 1988;250(1):125
|
lipoprotein-associated phospholipase A(2)
| EC 3.1.1.-
|
*Phospholipases A.
|
Bioorg Med Chem Lett 2000 Feb 21;10(4):395-8
|
| methyl arachidonylfluorophosphonate
| 0
|
*Arachidonic Acids *Phosphonic Acids Phospholipases A/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
|
J Biol Chem 1997 Feb 7;272(6):3231-7
|
| phospholipase A2 IV
| EC 3.1.-
|
*Phospholipases A Snake Venoms Trimeresurus.
|
Toxicon 1993 Aug;31(8):957-67
|
| lipomodulin
| 0
|
*Annexins Glycoproteins Lymphokines Phospholipases A/antagonists & inhibitors.
Pharma Action Phosphodiesterase Inhibitors
|
Proc Natl Acad Sci USA 1981;78(5):3199
|
| myotoxin II, Bothrops asper
| EC 3.1.1.-
|
*Phospholipases A Crotalid Venoms Neurotoxins.
|
Toxicon 1989;27(7):725
|
2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid
| 99754-06-0
|
*Aminobenzoic Acids *Cinnamates Phospholipases A/antagonists & inhibitors.
Pharma Action Phosphodiesterase Inhibitors
|
Biochim Biophys Acta 1989;1012(1):97
|
| taipoxin
| 52019-39-3
|
*Elapid Venoms Phospholipases A.
Pharma Action Neuromuscular Blocking Agents
|
Br J Pharmacol 61(1):133;1977; Eur J Biochem 94(2):531;1979; Naunyn Schmiedebergs Arch Pharmacol 299(2):155;1977; Neuroscience 4(6):837;1979; Toxicon 15:571;1977
|
| group X secretory phospholipase A2
| EC 3.1.1.-
|
*Phospholipases A.
|
FEBS Lett 2001 Dec 7;509(2):250-4
|
| outer membrane phospholipase A
| EC 3.1.-
|
Escherichia coli Proteins Bacterial Proteins *Bacterial Outer Membrane Proteins *Phospholipases A.
|
Biochemistry 2000 Aug 22;39(33):10017-22
|
| group V secretory phospholipase A2
| EC 3.1.-
|
Isoenzymes *Phospholipases A.
|
Hybridoma 2000 Apr;19(2):171-6
|
| ammodytoxin C
| 122933-83-9
Phospholipase A2 (Vipera ammodytes ammodytes venom ammodytoxin C reduced)
|
*Viper Venoms Phospholipases A.
|
Nucleic Acids Res 1989;17(11):4367
|
| PLA2G2A protein, human
| EC 3.1.1.4
|
*Phospholipases A.
|
Genomics 1997 Jan 1;39(1):38-46
|
| PLIalpha
| 0
|
*Blood Proteins Glycoproteins Phospholipases A/antagonists & inhibitors.
|
Biochim Biophys Acta 1999 Oct 18;1441(1):51-60
|
| IS 741
| 0
|
*Pyridines Phospholipases A/antagonists & inhibitors.
|
Chem Pharm Bull (Tokyo) 1995 Oct;43(10):1696-700
|
phospholipase A2-beta
| EC 3.1.1.-
|
*Phospholipases A Isoenzymes.
|
J Biol Chem 1999 Jun 11;274(24):17063-7
|
| enhancing factor
| 0
|
*Phospholipases A.
|
FEBS Lett 1986;207(1):142
|
| ammodytin L
| 130958-63-3
|
*Viper Venoms Phospholipases A.
|
Nucleic Acids Res 1990;18(15):4601
|
| group IB secretory phospholipase A2
| EC 3.1.-
|
Apoptosis *Phospholipases A.
|
J Neurochem 2002 May;81(3):449-61
|
| myotoxin I
| EC 3.1.1.-
|
*Phospholipases A Crotalid Venoms Neurotoxins.
|
Toxicon 1992 Mar;30(3):239-45
|
1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol
| 137464-44-9
|
*Glycerophosphates Phospholipases A/antagonists & inhibitors.
|
Biochem J 1992 Dec 1;288(Pt 2):407-11
|
| LY 315920
| 0
|
*Acetic Acids *Indoles Phospholipases A/antagonists & inhibitors.
|
J Pharm Exp Ther 1999 Mar;288(3):1117-24
|
| plipastatin
| 0
|
*Fatty Acids *Oligopeptides *Peptides, Cyclic Phospholipases A/antagonists & inhibitors.
|
J Antibiot (Tokyo) 1986;39(6):737
|
| SB 203347
| 0
|
*Sulfonamides Phospholipases A/antagonists & inhibitors.
|
J Pharmacol Exp Ther 1995 Sep;274(3):1254-62
|
phospholipase A2-V, Trimeresurus
| EC 3.1.1.-
|
*Phospholipases A.
|
Toxicon 1995 Nov;33(11):1469-78
|
phospholipase A2-gamma
| EC 3.1.1.-
|
*Phospholipases A.
|
J Biol Chem 1998 Aug 21;273(34):21926-32
|
| Agkistrodon platelet aggregation inhibitor
| EC 3.1.1.-
|
*Crotalid Venoms Phospholipases A.
|
Toxicon 1984;22(2):243
|
| bothropstoxin II
| EC 3.1.1.-
|
*Phospholipases A Crotalid Venoms.
|
Exp Mol Pathol 1991;55(3):217
|
| gravidin
| 0
|
*Pregnancy Proteins Phospholipases A/antagonists & inhibitors.
|
Am J Obstet Gynecol 1989;160(3):602
|
| demethoxyviridin
| 56660-21-0
|
*Androstenes Phospholipase C/antagonists & inhibitors Phospholipase D/antagonists & inhibitors Phospholipases A/antagonists & inhibitors.
|
Br J Pharmacol 1991;103(1):1237
|
| indoxam
| 0
|
*Carbamates *Indolizines Phospholipases A/antagonists & inhibitors.
|
Biochim Biophys Acta 1999 May 18;1438(2):213-22
|
| phospholipase A2 inhibitor protein, Crotalus
| 0
|
*Glycoproteins *Reptilian Proteins Crotalid Venoms Phospholipases A/antagonists & inhibitors.
|
J Biol Chem 1994 Jun 3;269(22):15646-51
|
| palmitoyl trifluoromethyl ketone
| 0
|
*Ketones Phospholipases A/antagonists & inhibitors.
|
Adv Exp Med Biol 1997;407:99-103
|
| thielocin A1beta
| 134933-42-9
|
*Xanthenes Phospholipases A/antagonists & inhibitors.
|
J Antibiot (Tokyo) 1991 Dec;44(12):1467-70
|
| petrosaspongiolide m
| 0
|
Oleanolic Acid/*analogs & derivatives Phospholipases A/antagonists & inhibitors.
|
J Pharmacol Exp Ther 1999 Apr;289(1):166-72
|
| chloracizine
| 800-22-6
2-chloro-10-(3-diethylaminopropionyl)phenothiazine
|
*Phenothiazines Phospholipases A/antagonists & inhibitors.
|
Biochem Pharmacol 27(17):2177;1978; Biol Nauki 4:33;1976; Br J Pharmacol 58(2):189;1976; Cor Vasa 17(2):125;1975; Farm Toksikol 38(3):313;1975
|
| Rosenthal's inhibitor
| 7059-39-4
|
*Stearates Phospholipases A/antagonists & inhibitors.
|
J Cell Physiol 92(1):91;1977
|
3-(4-octadecyl)benzoylacrylic acid
| 133800-88-1
|
*Acrylates *Benzoates Phospholipases A/antagonists & inhibitors.
|
Agents Actions 1991;32(1-2):144
|
| prophospholipase A2
| EC 3.1.1.-
|
*Enzyme Precursors *Phospholipases A.
|
Biochem Biophys Res Commun 1994 Jan 14;198(1):10-5
|
| piratoxin I
| EC 3.1.1.-
|
*Phospholipases A Crotalid Venoms.
|
Toxicon 1998 Mar;36(3):547-51
|
| ammodytoxin B
| 105732-90-9
Phospholipase A2 (Vipera ammodytes ammodytes venom ammodytoxin B reduced)
|
*Viper Venoms Phospholipases A.
|
Biol Chem Hoppe Seyler 1986;367(9):919
|
| basic protein I
| 0
|
*Proteins Crotalid Venoms Phospholipases A.
|
Toxicon 1990;28(1):43
|
| Oxyuranus scutellatus toxin 2
| EC 3.1.1.-
|
*Phospholipases A Elapid Venoms.
|
Neurochem Res 1991 Jun;16(6):651-8
|
1-(hexylthio)-2-(hexanoylamino)-1,2-dideoxy-sn-glycero-3-phosphocholine
| 144000-46-4
|
*Phosphatidylcholines Phospholipases A/antagonists & inhibitors.
|
Biochemistry 1993 May 18;32(19):5009-16
|
| U 10029A
| 89139-29-7
|
*Propanolamines Phospholipases A/antagonists & inhibitors.
|
Endocrinology 1985;116(4):1506
|
| SR 41319
| 96538-83-9
SR 41319
|
*Diphosphonates Phospholipases A/antagonists & inhibitors.
|
Agents Actions 1985;16(1-2):41
|
| myotoxin III, Bothrops asper
| 0
|
Phospholipases A Crotalid Venoms Neurotoxins.
|
Toxicon 1993 Feb;31(2):217-22
|
| myotoxin II, Bothrops moojeni
| EC 3.1.1.-
|
*Phospholipases A Crotalid Venoms.
|
Toxicon 1998 Mar;36(3):503-14
|
BnSP-7
| EC 3.1.1.-
|
*Crotalid Venoms *Phospholipases A.
|
Arch Biochem Biophys 2000 Jun 15;378(2):201-9
|
| caudoxin
| EC 3.1.1.-
|
*Phospholipases A Neurotoxins Viper Venoms.
|
Toxicon 1982;20(3):637
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