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Azetidines

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Definition:   do not confuse with AZETINES   
Examples Azetidinecarboxylic Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-(2-azetidinylmethoxy)-5-(3'-fluoropropyl)pyridine  0   *Azetidines *Pyridines Fluorine Radioisotopes Nicotinic Antagonists. Nucl Med Biol. 2011 Nov;38(8):1183-92.
1-(4-fluorobenzoyl)-3-(((6-methoxy-2-naphthyl)oxy)methyl)azetidine-3-carboxylic acid  0   *Azetidines Receptors, Prostaglandin E, EP2 Subtype. Br J Pharmacol. 2011 Dec;164(7):1847-56.
1,1'-(ethane-1,2-diyl)bis(3-chloro-4-(3,4-dimethoxyphenyl)azetidin-2-one)  0   *Azetidines. Med Chem. 2011 Jul 1;7(4):325-32
5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide  0   *Azetidines *Diphenylacetic Acids Receptor, Muscarinic M3/antagonists & inhibitors. J Med Chem. 2011 Oct 13;54(19):6888-904.
AZD 2738  0   *Azetidines *Benzamides Receptors, Neurokinin-1/antagonists & inhibitors Receptors, Neurokinin-2/antagonists & inhibitors. Drug Dev Ind Pharm 2011 Jun;37(6):719-26
AZD 8081  0   *Azetidines *Benzamides Receptors, Neurokinin-1/antagonists & inhibitors Receptors, Neurokinin-2/antagonists & inhibitors. Drug Dev Ind Pharm 2011 Jun;37(6):702-13
3-(1-(1-((4-chlorophenyl)(3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl)methyl)azetidin-3-yl)-2-fluoro-2-methylpropyl)-5-fluorobenzonitrile  0   *Azetidines *Oxadiazoles Receptor, Cannabinoid, CB1. Behav Pharmacol 2011 Apr;22(2):91-100
CE-178253  0   *Azetidines *Triazines. BMC Pharmacol. 2010;10() (dup#11): 9
CA 432  0   *Azetidines Guaiacol/*analogs & derivatives. J Pharmacol Exp Ther 2010 Nov;335(2):302-13
1-(7-(2-chlorophenyl)-8-(4-chlorophenyl)-2-methylpyrazolo(1,5-a)(1,3,5)triazin-4-yl)-3-(methylamino)azetidine-3-carboxamide  0   *Azetidines *Triazines Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Oct;335(1):103-13
AR-H067637  0   *Amidines *Azetidines. Thromb Haemost. 2009 Jun;101(6):1051-9
AZD 0837  0   *Amidines *Azetidines. Thromb Haemost 2010 Mar 1;103(3):604-12
VER 156084  0   *Azetidines *Piperidines. Bioorg Med Chem Lett 2009 Aug 1;19(15):4241-4
PF 03376056  0   *Azetidines *Indazoles DNA Gyrase/antagonists & inhibitors. Drug Metab Lett 2009 Jan;3(1):28-34
5-(11C)methyl-3-(2-(S)-azetidinylmethoxy)pyridine  0   *Azetidines *Pyridines. Biol Pharm Bull. 2009 Mar;32(3):337-40
4-acetoxy-2-azetidinone  0   *Azetidines. Org Lett 2009 Mar 19;11(6):1293-5
3-azido-4-oxoazetidine-2-carbaldehyde  0   *Azetidines. J Org Chem. 2008 Feb 15;73(4):1635-8
1-(7-(2-chlorophenyl)-8-(4-chlorophenyl)-2-methylpyrazolo(1,5-a)-(1,3,5)triazin-4-yl)-3-ethylaminoazetidine-3-carboxylic acid amide  0   *Azetidines *Triazines. J Pharmacol Exp Ther 2007 Oct;323(1):318-26
3-mercapto-1-(1,3-thiazolin-2-yl)azetidine  0   *Azetidines *Thiazoles. Chem Pharm Bull (Tokyo). 2006 Oct;54(10):1408-11
sazetidine-A  0   *Azetidines *Pyridines. Mol Pharmacol 2006 Oct;70(4):1454-60
1-(4-((4-phenyl-5-trifluoromethyl-2-thienyl)methoxy)benzyl)azetidine-3-carboxylic acid  0   *Azetidines *Thiophenes Receptors, Lysosphingolipid/agonists. Drug Metab Dispos 2006 Aug;34(8):1367-75
1-nitro-3,3'-dinitroazetidine  0   *Azetidines *Nitro Compounds. J Hazard Mater. 2006 Jun 30;134(1-3):8-18
5-(5-acetyl-2-butoxy-3-pyridinyl)-3-ethyl-2-(1-ethyl-3-azetidinyl)-2,6-dihydro-7H-pyrazolo(4,3-d)pyrimidin-7-one  0   *Azetidines *Pyrimidinones. J Med Chem 2006 Jun 15;49(12):3581-94
ezetimibe glucuronide  0   *Azetidines *Glucuronides. Clin Ther. 2006 Mar;28(3):373-87
1-(2-amino-3-methyl-butyryl)-azetidine-2-carbonitrile  0   *Azetidines *Nitriles. Brain Res. 2005 Jun 28;1048(1-2):177-84
LY368052  0   *Azetidines *Mandelic Acids. Am J Physiol Heart Circ Physiol 2005 Apr;288(4):H1508-14
1,3,3-Trinitroazetidine  0   *Azetidines *Nitro Compounds. J Hazard Mater. 2004 Sep 10;113(1-3):35-43
6-fluoro-3-(2-azetidinylmethoxy)pyridine  0   *Azetidines Fluorine Radioisotopes. Synapse 2004 Sep 1;53(3):184-9
ezetimibe, simvastatin drug combination  0   *Azetidines *Simvastatin Drug Combinations. Med Lett Drugs Ther 2004 Sep 13;46(1191):73-4VYTORIN; EZETIMIBE; SIMVASTATIN
S-2-aminomethylazetidine  0   *Azetidines. Chem Pharm Bull (Tokyo). 2004 Jan;52(1):47-50
6-chloro-3-((2-azetidinyl)methoxy)-5-(2-fluoropyridin-5-yl)pyridine  0   *Pyridines *Azetidines Fluorine Radioisotopes Ligands. J Med Chem 2004 May 6;47(10):2453-65
ethyl melagatran  0   *Amidines *Azetidines. Drug Metab Dispos 2003 May;31(5):645-51
N-hydroxymelagatran  0   *Amidines *Azetidines. Drug Metab Dispos 2003 May;31(5):645-51
SCH 58053  0   *Azetidines *Spiro Compounds. J Lipid Res. 2002 Nov;43(11):1864-74
7-(3-aminoazetidin-1-yl)-1-(5-amino-2,4-difluorophenyl)-8-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid  0   *Azetidines *Quinolines. J Med Chem 2003 May 8;46(10):1905-17
BMS-262084  0   *Azetidines *Piperazines. J Org Chem 2002 May 31;67(11):3595-600
2,4-dimethylazetidine  0   *Azetidines. J Med Chem 2002 Sep 12;45(19):4344-9
3-benzylazetidin-2-one  0   *Azetidines. Bioorg Med Chem 2001 Nov;9(11):3065-75
((-)-7-(3-amino-1-azetidinyl)-8-chloro-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid)  0   *Azetidines *Quinolones. Antimicrob Agents Chemother 2001 Nov;45(11):3113-21
((-)-7-(3-amino-2-methyl-1-azetidinyl)-8-chloro-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid)  0   *Azetidines *Quinolones. Antimicrob Agents Chemother 2001 Nov;45(11):3113-21
3,3-dichloro-N-4-methoxyphenyl-4-(2-phenylstyryl)-2-azetidinone  0   *Azetidines *Styrenes. Anal Sci 2001 Jul;17(7):909-10
4-(1-((bis(4-methylphenyl)methyl)carbamoyl)-3-(2-ethoxybenzyl)-4-oxoazetidine-2-yloxy)benzoic acid  0   *Azetidines *Benzoic Acids. Jpn J Pharmacol 2001 May;86(1):124-6
4-benzyloxycarbonyl-1-(3'-(benzyloxycarbonyl)phenylacetate)-3(4'-hydroxybenzyl)-2-azetidinone  0   *Azetidines Prostate-Specific Antigen/antagonists & inhibitors. J Med Chem 2001 May 10;44(10):1491-508
5-iodo-3-(2-azetidinylmethoxy)pyridine  0   *Azetidines *Pyridines. Nucl Med Biol 2001 Jan;28(1):91-6
ximelagatran  0   *Azetidines *Benzylamines.
Pharma Action Antithrombins 		Thromb Res 2001 Feb 1;101(3):171-81
4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-3-(3,4,5-trimethylphenyl)-1,2-dihydroquinoline-6-carboxylic acid pyrimidin-4-ylamide  0   *Azetidines *Quinolones Receptors, Gastrointestinal Hormone/antagonists & inhibitors. J Med Chem 2001 Mar 15;44(6):917-22
4-acetoxy-3-hydroxyethyl-2-azetidinone  0   *Azetidines. J Antibiot (Tokyo) 2000 Oct;53(10):1231-4
4-(1-(2-(1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxo-3-piperidyl)ethyl)azetidin-3-yl)-1-piperazine sulfamide  0   *Azetidines *Piperazines Receptors, Neurokinin-2/antagonists & inhibitors. Xenobiotica 2000 Jun;30(6):627-42
okaramine B  0   *Azetidines *Azocines *Indole Alkaloids. Biosci Biotechnol Biochem 2000 Jul;64(7):1519-21
3-phenyl-1-(1-phenylethyl)-4-(1-phenylethyliminomethyl)azetidin-2-one  0   *Azetidines *Imines. Acta Crystallogr C 2000 Apr;56( Pt 4):481-3
SCH 60663  0   *Azetidines. Br J Pharmacol 2000 Apr;129(8):1748-54
dirhodium(II) tetrakis(methyl 2-oxaazetidine-4-carboxylate)  0   *Azetidines *Organometallic Compounds Rhodium. Org Lett 2000 Apr 20;2(8):1145-7
1-O-(4-(1-(4-benzoylphenyl)-3--(3-hydroxy-3-(4-iodophenyl)propyl)-2-oxo-4-azetidinyl)phenyl)glucuronic acid  0   *Azetidines *Glucuronic Acids. Bioorg Med Chem 1999 Oct;7(10):2199-202
1-(2-(2-methyl-4-nitrophenyl)diaz-1-enyl)pyrrolidine-2-carboxylic acid  0   *Azetidines Proline/*analogs & derivatives. Appl Environ Microbiol 1999 Jul;65(7):3258-60
5-((76)Br)bromo-3-((2-azetidinyl)methoxy)pyridine  0   *Azetidines *Pyridines Ligands. J Neurochem 1999 Sep;73(3):1264-72
2-fluoro-3-(2-azetidinylmethoxy)pyridine  0   *Azetidines *Pyridines Fluorine Radioisotopes Ligands. J Med Chem 1999 Jun 17;42(12):2251-9
SB 222657  0   *Azetidines *Sulfoxides Phospholipases A/antagonists & inhibitors. Biochem J 1999 Mar 1;338( Pt 2):479-87
3-(1-tert-butyldimethylsilyloxyethyl)--4-(4-chloro-3-oxo-2-butyl)azetidinone  0   *Azetidines *Organosilicon Compounds. Bioorg Med Chem Lett 1998 Feb 3;8(3):255-6
3-(1-tert-butyldimethylsilyloxyethyl)-4-(4-bromo-3-oxo-2-butyl)azetidinone  0   *Azetidines *Organosilicon Compounds. Bioorg Med Chem Lett 1998 Feb 3;8(3):255-6
2-azetidinone  0   *Azetidines. Bioorg Med Chem 1998 Sep;6(9):1429-37
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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