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Polysaccharide-Lyases

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Definition: A group of carbon-oxygen lyases. These enzymes catalyze the breakage of a carbon-oxygen bond in polysaccharides leading to an unsaturated product and the elimination of an alcohol. EC 4.2.2.     
Examples Chondroitinases and Chondroitin Lyases; Heparin Lyase; Hyaluronoglucosaminidase
Other names Polysaccharide Lyases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PLA2 protein, Arabidopsis  EC 4.2.2.2   *Polysaccharide-Lyases *Arabidopsis Proteins. Plant Cell Physiol 2006 Jun;47(6):788-92
Cup s 1 allergen, Cupressus sempervirens  EC 4.2.2.2   *Polysaccharide-Lyases *Antigens, Plant Pollen. Allergol Immunopathol (Madr) 2004 Nov-Dec;32(6):319-25
vAL-1 protein, chlorovirus CVK2  EC 4.2.2.-   *Polysaccharide-Lyases. FEBS Lett 2004 Feb 13;559(1-3):51-6
PMR6 protein, Arabidopsis  EC 4.2.2.2   *Polysaccharide-Lyases *Arabidopsis Proteins. Plant Cell 2002 Aug;14(8):2095-106
AT1G67750 protein, Arabidopsis  EC 4.2.2.2   *Phospholipases A *Polysaccharide-Lyases *Arabidopsis Proteins. Plant Physiol 2002 Sep;130(1):90-101
rhamnogalacturonan lyase 11A  EC 4.2.2.-   *Polysaccharide-Lyases. Biochem J 2001 Apr 1;355(Pt 1):167-77
pectate lyase 10A  EC 4.2.2.-   *Polysaccharide-Lyases. Biochem J 2001 Apr 1;355(Pt 1):155-65
KflA protein, E coli  EC 4.2.2.-   *Polysaccharide-Lyases *Escherichia coli Proteins. J Bacteriol 2000 Jul;182(13):3761-6
PelL1 protein, Erwinia chrysanthemi  EC 4.2.2.2   *Bacterial Proteins *Polysaccharide-Lyases. Biochem Biophys Res Commun 2000 Feb 16;268(2):420-5
heparinase II  EC 4.2.2.-   *Polysaccharide-Lyases. J Biol Chem 1998 Sep 4;273(36):22904-12
ulvan-lyase  EC 4.2.2.-   *Polysaccharide-Lyases. Carbohydr Res 1997 Nov 28;304(3-4):325-33
glucuronan lyase  EC 4.2.2.-   *Polysaccharide-Lyases. Int J Biol Macromol 1997 Aug;21(1-2):3-9
hyaluronate lyase  EC 4.2.2.1   *Polysaccharide-Lyases.
rhamnogalacturonase B  EC 4.2.2.-   *Polysaccharide-Lyases. Plant Physiol 1996 Jan;110(1):73-7
PelE protein, Erwinia chrysanthemi  EC 4.2.2.-   *Bacterial Proteins *Polysaccharide-Lyases. Proteins 1995 Sep;23(1):32-7
gellan lyase  EC 4.2.2.-   *Polysaccharide-Lyases. Microbiology 1994 Nov;140(Pt 11):3007-13
heparatinase II  EC 4.2.2.-   *Polysaccharide-Lyases. Int J Biochem 1993 Sep;25(9):1219-25
heparatinase I  EC 4.2.2.-   *Polysaccharide-Lyases. Int J Biochem 1993 Sep;25(9):1219-25
alpha-1,4-glucan lyase  EC 4.2.2.13   *Polysaccharide-Lyases. Biochim Biophys Acta 1993 Mar 21;1156(3):313-20
pectin lyase B  EC 4.2.2.10   *Polysaccharide-Lyases. Gene 1992 Apr 1;113(1):95-9
oligogalacturonate lyase  EC 4.2.2.-   *Bacterial Proteins *Polysaccharide-Lyases. J Bacteriol 1985;162(2):708
pectate disaccharide-lyase  EC 4.2.2.9   *Polysaccharide-Lyases. J Gen Microbiol 1982;128(11):2661
pectin lyase  EC 4.2.2.10   *Polysaccharide-Lyases. Anal Biochem 1980;107(1):177
pectate lyase  EC 4.2.2.2   *Polysaccharide-Lyases. Biokhimiia 38(5):1054;1973; Can J Microbiol 25(1):95;1979; J Bacteriol 132(3):862;1977; J Chromatogr 116(2):395;1976; J Sci Food Agric 26:197;1975; Nature 269(5625):237;1977; Prikl Biokhim Mikrobiol 14(6):833;1978
poly-alpha-L-guluronate lyase  EC 4.2.2.11   *Polysaccharide-Lyases. Carbohydr Res 57:163;1977
heparitinsulfate lyase  EC 4.2.2.8   *Polysaccharide-Lyases. J Biochem (Tokyo) 84(4):1005;1978; J Biol Chem 250:6841;1975
poly(beta-D-mannuronate) lyase  EC 4.2.2.3   *Polysaccharide-Lyases. Biochim Biophys Acta 569(2):259;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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