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Bromouracil

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Definition: 5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.  an antimetabolite   
Pharmacological Action Antimetabolites; Mutagens 		Other names 5 Bromouracil; Bromuracil; 5-Bromouracil
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-(2-fluoro-2-deoxyarabinofuranosyl)-5-bromouracil  0   Bromouracil/*analogs & derivatives Bromine Radioisotopes. Nucl Med Biol 2002 Jul;29(5):527-35
1-(2-fluoro-2-deoxy-3,5-O-dibenzoylarabinofuranosyl)-5-bromouracil  0   Bromouracil/*analogs & derivatives Bromine Radioisotopes. Nucl Med Biol 2002 Jul;29(5):527-35
1,1'(2''-bromo-2''-chloroethenyl)-bis-(5-bromouracil)  0   Bromouracil/*analogs & derivatives. Int J Biol Macromol 1999 Dec 1;26(4):243-8
5-bromo-1,3,6-trimethyluracil  15018-59-4   Bromouracil/*analogs & derivatives. Bioorg Med Chem 1995 Jul;3(7):891-7
1-amino-5-bromouracil  127984-93-4   Bromouracil/*analogs & derivatives. Arzneimittelforshung 1994 Mar;44(3):285-8
5-(2-bromovinyl)uracil  69304-49-0   Bromouracil/*analogs & derivatives. Carcinogenesis 1985;6(8):1207
6-amino-5-bromouracil  6312-73-8   Bromouracil/*analogs & derivatives Thymidine Phosphorylase/antagonists & inhibitors. Biochem Pharmacol 1983;32(23):3583
1-methyl-5-bromouracil  6327-97-5   Bromouracil/*analogs & derivatives. Int J Radiat Biol 1981;40(5):493
5-bromo-6-azauracil  4956-05-2   Bromouracil/*analogs & derivatives. Experientia 1981;37(1):36
bromacil  314-40-9 5-bromo-3-sec-butyl-6-methyluracil  Bromouracil/*analogs & derivatives.
Pharma Action Herbicides 		Pestic Monit J 12(2):47;1978; Toxicol Appl Pharmacol 34(2):189;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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