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Calcium Channel Blockers

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Definition: A class of drugs that act by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. Since they are inducers of vascular and other smooth muscle relaxation, they are used in the drug therapy of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms.  vasodilators; D25-26 qualif; DF: CA CHANNEL BLOCK   
See Also Anti-Arrhythmia Agents; Antihypertensive Agents; Vasodilator Agents 		Other names Channel Blockers, Calcium; Calcium Inhibitors, Exogenous; Calcium Blockaders, Exogenous; Calcium Antagonists, Exogenous; Inhibitors, Exogenous Calcium; Blockers, Calcium Channel; Blockaders, Exogenous Calcium; Antagonists, Exogenous Calcium; Exogenous Calcium Inhibitors; Exogenous Calcium Blockaders; Exogenous Calcium Antagonists; Calcium Channel Blocking Drugs
Substances having this pharmacologic action: stepholidine; terodiline; niludipin; enpiperate; ochratoxin A; berbamine; falipamil; eperisone; piperidine; darodipine; nilvadipine; fosfedil; dauricine; 1,4-dihydropyridine; gabapentin; canadine; fenamic acid; Mibefradil; omega-Conotoxin GVIA; omega-Agatoxin IVA; Conotoxins; omega-Conotoxins; tetrandrine; tolfenamic acid; 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate; caroverine; Amrinone; Flunarizine; Cinnarizine; Lidoflazine; Prenylamine; Nicardipine; Nifedipine; Nimodipine; Isradipine; Amlodipine; Nitrendipine; Verapamil; Felodipine; Nisoldipine; Bepridil; Magnesium Sulfate; Gallopamil; Perhexiline; Bencyclane; Diltiazem; Fendiline; 2-(4-(dimethylamino)styryl)-1-methylpyridinium; tranilast; pinaverium; octylonium; tetrahydropalmatine; dimeditiapramine; norverapamil; amlodipine, atorvastatin drug combination; NS 21; ziconotide; anandamide; IH 764-3; dotarizine; azimilide; efonidipine; monatepil; Win 55212-2; FTX, spider toxin; risedronic acid; omega-conotoxin-MVIIC; fantofarone; lacidipine; lercanidipine; benidipine; carboxyamido-triazole; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole; sesamodil; naftopidil; AE0047; cilnidipine; Conus magus toxin; oxodipine; niguldipine; CD 349; manidipine; R 56865; devapamil; clentiazem; pranidipine; lamotrigine; fasudil; PN 202-791; mepirodipine; KW 3049; KT 362; KB 2796; emopamil; N-(2-guanidinoethyl)-5-isoquinolinesulfonamide; anipamil; manoalide; SAN 202791; ryodipine; osthol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3,5-dichloro-N-(1-(2,2-dimethyltetrahydropyran-4-ylmethyl)-4-fluoropiperidin-4-ylmethyl)benzamide  0   *Benzamides *Piperidines Calcium Channel Blockers Calcium Channels, T-Type. J Neurophysiol. 2011 Nov;106(5):2653-61.
A-1048400  0   *Piperidones Analgesics Calcium Channel Blockers. Biochem Pharmacol. 2012 Feb 1;83(3):406-18
ethyl 4-(4'-heptanoyloxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylate  0   *Pyrimidinones Calcium Channel Blockers. Biochimie 2011 Jul;93(7):1146-56
PD 173212  0   *Dipeptides Calcium Channel Blockers. Bioorg Med Chem Lett 1999 Jul 5;9(13):1813-8
AWD 160-275  0   *Amino Acids *Cyclohexylamines Calcium Channel Blockers. Vestn Ross Akad Med Nauk 1998;(11):42-6
OF 5015  0   Organic Chemicals Calcium Channel Blockers. Biull Eksp Biol Med 1993 Sep;116(9):288-90
falicor  0   Organic Chemicals Calcium Channel Blockers. Klin Med (Mosk) 1990;68(10):83
azelnidipine  123524-52-7 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)  *Dihydropyridines Azetidinecarboxylic Acid/*analogs & derivatives Calcium Channel Blockers. Jpn J Pharmacol 1989;51(1):57
ryosidine  89964-00-1   Organic Chemicals Calcium Channel Blockers. Naunyn Schmiedebergs Arch Pharmacol 1984;325(2):124
R 33956  87495-26-9 R 33956  Organic Chemicals Calcium Channel Blockers. Am J Physiol 1983;244(3):C150
tetramethylpyrazine  1124-11-4   *Pyrazines Adrenergic beta-Agonists Anti-Inflammatory Agents, Non-Steroidal Calcium Channel Blockers Fibrinolytic Agents Platelet Aggregation Inhibitors Ligusticum.
Pharma Action Vasodilator Agents 		Chin Med J (Engl) 4(4):319;1978; J Chromatogr A. 2004 Aug 27;1047(2):249-53; Life Sci 2005 Nov 26;78(2):128-133; Planta Med 1980;38(2):144; Planta Med 1980;38(4):332; Yao Hsueh Hsueh Pao 1979;14(10):624
propiverine  60569-19-9   *Benzilates Antiparkinson Agents Calcium Channel Blockers Urinary Incontinence.
Pharma Action Parasympatholytics ; Cholinergic Antagonists 		Psychiat Neurol Med Psychol 20(21):77;1975
vinpocetine  42971-12-0 eburnamenine-14-carboxylic acid, ethyl ester, (3 alpha,16 alpha)  *Vinca Alkaloids Anticonvulsants Antihypertensive Agents Calcium Channel Blockers.
Pharma Action Phosphodiesterase Inhibitors ; Vasodilator Agents ; Neuroprotective Agents ; Nootropic Agents 		Acta Pharm Hung 48(suppl):54;1978; Arch Int Pharmacodyn 226:139;1977; Arzneim Forsch 1979;29(6):953; Arzneim Forsch 1979;29(6):957; Arzneim Forsch 26(10a):1907;1976; Br J Clin Pharmacol 1980;9(1):100; Ther Hung 1979;21(1):15; Ther Hung 1979;27(1):17; Ther Hung 1979;27(1):29; Ther Hung 1979;27(4):182; Ther Hung 26(1):16;1978; Ther Hung 26(4):181;1978
nimesulide  51803-78-2 methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)  *Sulfonamides Calcium Channel Blockers Platelet Aggregation Inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Cyclooxygenase Inhibitors 		Arch Int Pharmacodyn Ther 221(1):132;1976; Arch Int Pharmacodyn Ther 238(2):344;1979; Biochem Pharmacol 26(4):307;1977; Ginekol Pol 50(4):299;1979; J Pharm Sci 66(12):1700;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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