Definition: A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
alkyating antineoplastics; do not confuse with NITROGEN MUSTARD, a specific chemical; DF: NITROGEN MUSTARD CPDS
Other names Mustard Compounds, Nitrogen; Compounds, Nitrogen Mustard
Mutat Res 45:103;1977; Biochem Biophys Res Commun 84(2):411;1978; J Cell Physiol 88(3):343;1976; J Cell Physiol 94(2):187;1978; Mutat Res 46(1):11;1977; Mutat Res 49:407;1978; Mutat Res 54(1):61;1978; Proc Natl Acad Sci USA 71(11):4416;1974