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acridine half-mustard

under Nitrogen Mustard Compounds
More information in Books or onNLM PubMed
More on Nitrogen Mustard Compounds Definition: A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.  alkyating antineoplastics; do not confuse with NITROGEN MUSTARD, a specific chemical; DF: NITROGEN MUSTARD CPDS    Other names Mustard Compounds, Nitrogen; Compounds, Nitrogen Mustard
SubstanceCAS Registry & nameCategoriesSourceDrugs*
acridine half-mustard [ 2-chloro-6-methoxy-9-(3-(2-chloroethyl)aminopropylamino)acridine,ICR-191,acridine half-mustard, dihydrochloride ]
  RN given refers to parent cpd 		17070-44-9 N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-1,3-propanediamine  *Nitrogen Mustard Compounds Aminacrine/*analogs & derivatives
Pharma Action Mutagens 		Mutat Res 45:103;1977; Biochem Biophys Res Commun 84(2):411;1978; J Cell Physiol 88(3):343;1976; J Cell Physiol 94(2):187;1978; Mutat Res 46(1):11;1977; Mutat Res 49:407;1978; Mutat Res 54(1):61;1978; Proc Natl Acad Sci USA 71(11):4416;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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