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Helix-Loop-Helix Motifs

More information in Books or onNLM PubMed
Definition: Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.  do not confuse with HELIX-TURN-HELIX MOTIFS   
Examples EF Hand Motifs; Helix-Turn-Helix Motifs 		Other names HLH Motifs; Motifs, Helix Loop Helix; Motifs, HLH; Motif, Helix-Loop-Helix; Motif, HLH; Helix-Loop-Helix Motif; Helix Loop Helix Motifs; HLH Motif; Motifs, Helix-Loop-Helix
 
SubstanceCAS Registry & nameCategoriesSource
BHLHA9 protein, human  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. J Med Genet. 2012 Feb;49(2):119-25
Sim1 protein, rat  0   *Repressor Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Obesity (Silver Spring). 2009 Jul;17(7):1356-62
Tango7 protein, Drosophila  0   *Drosophila Proteins *Aryl Hydrocarbon Receptor Nuclear Translocator Helix-Loop-Helix Motifs. Nature. 2009 Jul 2;460(7251):123-7
Mych protein, zebrafish  0   *Transcription Factors *Zebrafish Proteins DNA-Binding Proteins Helix-Loop-Helix Motifs. PLoS ONE 2008;3(4):e2029
PAR2 protein, Arabidopsis  0   *Arabidopsis Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. EMBO J 2007 Nov 14;26(22):4756-67
PAR1 protein, Arabidopsis  0   *Arabidopsis Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Plant Physiol 2006 May;141(1):85-96
Npas4 protein, rat  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Eur J Neurosci. 2006 Nov;24(10):2705-20
KIDARI protein, Arabidopsis  0   *Carrier Proteins *Arabidopsis Proteins Helix-Loop-Helix Motifs. Plant Mol Biol 2006 May;61(1-2):283-96
PRE1 protein, Arabidopsis  0   *Transcription Factors *Arabidopsis Proteins Nuclear Proteins Helix-Loop-Helix Motifs. Plant Cell Physiol 2006 May;47(5):591-600
TCF15 protein, human  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
AIG1 protein, Arabidopsis  0   *Arabidopsis Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Biochim Biophys Acta 2006 Mar-Apr;1759(3-4):191-4
Sohlh1 protein, mouse  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Proc Natl Acad Sci U S A 2006 May 23;103(21):8090-5
Nan-1D protein, Arabidopsis  0   *Transcription Factors Helix-Loop-Helix Motifs. Mol Cells 2005 Jun 30;19(3):334-41
Pod1 protein, Xenopus  0   *Transcription Factors *Xenopus Proteins Helix-Loop-Helix Motifs. Int J Dev Biol 2005;49(1):59-63
Esr1 protein, Xenopus  0   *Repressor Proteins *Xenopus Proteins Nerve Tissue Proteins Helix-Loop-Helix Motifs. Development 1997 Feb;124(3):693-702
HLH-17 protein, C elegans  0   *Transcription Factors *Caenorhabditis elegans Proteins Helix-Loop-Helix Motifs. Gene 2005 Aug 15;356:1-10
Lisch7 protein, rat  0   *Receptors, LDL *Transcription Factors Leucine Zippers Helix-Loop-Helix Motifs. J Biol Chem 1999 May 7;274(19):13390-8
Scx protein, rat  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
Scx protein, mouse  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
NPAS3 protein, human  0   *Nerve Tissue Proteins *Transcription Factors Helix-Loop-Helix Motifs. Am J Med Genet B Neuropsychiatr Genet 2005 Jul 5;136(1):26-32
FIT1 protein, Arabidopsis  0   *Arabidopsis Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Plant Cell 2004 Dec;16(12):3400-12
Id3 protein, Xenopus  0   *Xenopus Proteins *Inhibitor of Differentiation Proteins Helix-Loop-Helix Motifs. Development 2005 Apr;132(8):1831-41
HEB protein, rat  0   *DNA-Binding Proteins *Muscle Proteins *Transcription Factors Helix-Loop-Helix Motifs. Differentiation 2004 Sep;72(7):327-40
beta3.1 protein, zebrafish  0   *Zebrafish Proteins *Basic Helix-Loop-Helix Transcription Factors Nerve Tissue Proteins Helix-Loop-Helix Motifs. Gene Expr Patterns 2004 Nov;5(1):35-41
Atoh1.2 protein, zebrafish  0   *Zebrafish Proteins *Basic Helix-Loop-Helix Transcription Factors Nerve Tissue Proteins Helix-Loop-Helix Motifs. Gene Expr Patterns 2004 Nov;5(1):35-41
Id3 protein, rat  0   *Inhibitor of Differentiation Proteins Helix-Loop-Helix Motifs. Circ Res 2004 Sep 17;95(6):557-9
Her11 protein, zebrafish  0   *Zebrafish Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Dev Genes Evol 2004 Aug;214(8):393-406
ASCL3 protein, human  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Genomics 2004 Nov;84(5):859-66
ASCL4 protein, human  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Genomics 2004 Nov;84(5):859-66
Hand2 protein, Xenopus  0   *Xenopus Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
Hand2 protein, rat  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
Hand2 protein, mouse  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
HAND2 protein, human  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
Hesl protein, rat  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Int J Mol Med 2004 Oct;14(4):747-51
HELT protein, human  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Int J Mol Med 2004 Oct;14(4):747-51
PIL5 protein, Arabidopsis  0   *Arabidopsis Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Plant Cell 2004 Nov;16(11):3045-58
PIF6 protein, Arabidopsis  0   *Arabidopsis Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Plant Cell 2004 Nov;16(11):3033-44
PIF5 protein, Arabidopsis  0   *Arabidopsis Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Plant Cell 2004 Nov;16(11):3033-44
YidZ protein, E coli  0   *Transcription Factors *Escherichia coli Proteins Helix-Loop-Helix Motifs. J Biol Chem 2005 Jan 28;280(4):2636-43
Bhlhb9 protein, rat  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. J Cell Biochem 2004 Apr 1;91(5):1030-42
BHLHB9 protein, human  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Nippon Yakurigaku Zasshi 2004 Sep;124(3):135-43
RERJ1 protein, rice  0   *Plant Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Biochem Biophys Res Commun. 2004 Dec 17;325(3):857-63
ETC2 protein, Arabidopsis  0   *Transcription Factors *Arabidopsis Proteins Helix-Loop-Helix Motifs. Plant Mol Biol 2004 May;55(3):389-98
Olig1 protein, mouse  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Mech Dev 2000 Dec;99(1-2):143-8
Tcfl5 protein, mouse  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Nucleic Acids Res 2004;32(21):6425-36
PIL6 protein, Arabidopsis  0   *Arabidopsis Proteins *Basic Helix-Loop-Helix Transcription Factors Signal Transduction Helix-Loop-Helix Motifs. Plant Cell Physiol 2004 Aug;45(8):1078-86
E(spl)M8 protein, Drosophila  0   *Repressor Proteins Helix-Loop-Helix Motifs. EMBO J 1989 Jan;8(1):203-10
Npas3 protein, mouse  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs. Mech Dev 1999 Nov;88(2):237-41
Nupr1 protein, mouse  0   *DNA-Binding Proteins *Neoplasm Proteins High Mobility Group Proteins Nuclear Proteins Phosphoproteins Helix-Loop-Helix Motifs.
P8 protein, human  0   *Neoplasm Proteins *Basic Helix-Loop-Helix Transcription Factors High Mobility Group Proteins Nuclear Proteins Phosphoproteins Helix-Loop-Helix Motifs.
Mist1 protein, mouse  0   *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
Xath-3 protein, Xenopus  0   *Nerve Tissue Proteins *Xenopus Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
Npas2 protein, mouse  0   *Nerve Tissue Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
Tcf4 protein, rat  0   *DNA-Binding Proteins *Transcription Factors Helix-Loop-Helix Motifs.
NEUROG2 protein, human  0   *Nerve Tissue Proteins *Basic Helix-Loop-Helix Transcription Factors Transcription Factors Helix-Loop-Helix Motifs.
SIM1 protein, human  0   *Repressor Proteins *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
ARNT2 protein, Xenopus  0   *Xenopus Proteins *Aryl Hydrocarbon Receptor Nuclear Translocator Helix-Loop-Helix Motifs Receptors, Aryl Hydrocarbon.
arnt2 protein, zebrafish  0   *Zebrafish Proteins *Aryl Hydrocarbon Receptor Nuclear Translocator Helix-Loop-Helix Motifs Receptors, Aryl Hydrocarbon.
NEUROD2 protein, human  0   *Neuropeptides *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
Neurod2 protein, rat  0   *Neuropeptides *Basic Helix-Loop-Helix Transcription Factors Helix-Loop-Helix Motifs.
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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