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Bradykinin

More information in Books or onNLM PubMed
Definition: A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.     
Pharmacological Action Vasodilator Agents
See Also Receptors, Bradykinin
Examples Kallidin 		Other names Arg Pro Pro Gly Phe Ser Pro Phe Arg; Bradykinin, (9-D-Arg)-Isomer; Bradykinin, (8-D-Phe)-Isomer; Bradykinin, (7-D-Pro)-Isomer; Bradykinin, (6-D-Ser)-Isomer; Bradykinin, (5-D-Phe-8-D-Phe)-Isomer; Bradykinin, (5-D-Phe)-Isomer; Bradykinin, (3-D-Pro-7-D-Pro)-Isomer; Bradykinin, (3-D-Pro)-Isomer; Bradykinin, (2-D-Pro-7-D-Pro)-Isomer; Bradykinin, (2-D-Pro-3-D-Pro-7-D-Pro)-Isomer; Bradykinin, (2-D-Pro)-Isomer; Bradykinin, (1-D-Arg)-Isomer; Bradykinin Triacetate; Bradykinin Hydrochloride; Bradykinin Diacetate; Bradykinin Acetate, (9-D-Arg)-Isomer; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
galanin(1-13)-Gln(14)-bradykinin(2-9)amide  0   *Peptide Fragments *Galanin Bradykinin/*analogs & derivatives. Neurosci Lett. 2011 Mar 24;491(3):174-6
amolopkinin W1  0   *Bradykinin. Peptides. 2009 May;30(5):893-900
amolopkinin W2  0   *Bradykinin. Peptides. 2009 May;30(5):893-900
B 10380  0   *Fluoresceins Bradykinin/*analogs & derivatives. Peptides 2008 Sep;29(9):1626-30
B 10330  0   Biotin/*analogs & derivatives Bradykinin/*analogs & derivatives. Peptides 2008 Sep;29(9):1626-30
amolopkinin protein, Amolops loloensis  0   *Bradykinin. Peptides 2006 Nov;27(11):2683-7
protopolybiakinin-2, Protopolybia exigua  0   *Bradykinin *Wasp Venoms. Peptides 2006 Nov;27(11):2632-9
protopolybiakinin-1, Protopolybia exigua  0   *Bradykinin *Wasp Venoms. Peptides 2006 Nov;27(11):2632-9
B-9958  0   Bradykinin/*analogs & derivatives. J Pharmacol Exp Ther. 2006 Apr;317(1):300-8
bradykinin, Hyp(3)-TyrMe(8)  0   Bradykinin/*analogs & derivatives Receptor, Bradykinin B2/agonists. Methods Find Exp Clin Pharmacol 2004 May;26(4):247-52
Ac-Orn-(Oic2, alpha-MePhe5, D-betaNal7, Ile8)desArg9-bradykinin  0   Bradykinin/*analogs & derivatives. Can J Physiol Pharmacol. 2002 Dec;80(12):1203-7
MAP4-RPPGF  0   *Peptide Fragments Bradykinin/*analogs & derivatives.
des-arginine(11)-T-kinin, rat  0   Bradykinin/*analogs & derivatives. Eur J Pharmacol 2002 Aug 23;450(2):123-30
NSC 710295  0   *Peptides Bradykinin/antagonists & inhibitors. J Pharm Biomed Anal 2002 May 15;28(3-4):601-12
bromobradykinin  0   Bradykinin/*analogs & derivatives. Rapid Commun Mass Spectrom 2002;16(3):220-8
B 10284  0   *Oligopeptides Bradykinin/antagonists & inhibitors. J Biomol Struct Dyn 2000 Oct;18(2):249-60
B 10148  0   *Oligopeptides Bradykinin/antagonists & inhibitors. J Biomol Struct Dyn 2000 Oct;18(2):249-60
B 10206  0   *Oligopeptides Bradykinin/antagonists & inhibitors. J Biomol Struct Dyn 2000 Oct;18(2):249-60
Pam-Gly(-1)-Lys(0)-Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)-OH  0   *Lipopeptides Bradykinin/*analogs & derivatives Receptors, Bradykinin/agonists. Biopolymers 2001 Apr 15;58(5):511-20
Tyr-Lys-bradykinin  0   Bradykinin/*analogs & derivatives. J Am Soc Mass Spectrom 2001 Feb;12(2):222-7
bradykinin (2-9)  0   *Bradykinin *Peptide Fragments. Brain Res. 2000 Dec 15;886(1-2):67-72
BKM 872  0   *Peptides, Cyclic Bradykinin/antagonists & inhibitors. J Biomol Struct Dyn 2000 Jun;17(6):947-55
BKM 870  0   *Peptides, Cyclic Bradykinin/antagonists & inhibitors. J Biomol Struct Dyn 2000 Jun;17(6):947-55
BKM 824  0   *Peptides, Cyclic Bradykinin/antagonists & inhibitors. J Biomol Struct Dyn 2000 Jun;17(6):947-55
JMV 1465  0   Bradykinin/*analogs & derivatives Receptors, Bradykinin/agonists. J Med Chem 1999 Oct 7;42(20):4193-201
JMV 1609  0   Bradykinin/*analogs & derivatives Receptors, Bradykinin/agonists. J Med Chem 1999 Oct 7;42(20):4193-201
arginyl-prolyl-prolyl--glycyl-phenylalanyl-seryl-(3S)(amino)-5-(carbonylmethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one-arginine  0   Bradykinin/*analogs & derivatives Receptors, Bradykinin/agonists. J Med Chem 1999 Oct 7;42(20):4185-92
JMV 1116  0   Bradykinin/*analogs & derivatives Receptors, Bradykinin/agonists. J Med Chem 1999 Oct 7;42(20):4185-92
B 9430  0   Bradykinin/*analogs & derivatives Receptors, Bradykinin/antagonists & inhibitors. Eur J Pharmacol 1999 Jul 2;376(1-2):83-9
B 9858  0   Bradykinin/*analogs & derivatives Receptors, Bradykinin/antagonists & inhibitors. Eur J Pharmacol 1999 Jul 2;376(1-2):83-9
R 715  0   Bradykinin/*analogs & derivatives Receptors, Bradykinin/antagonists & inhibitors. Neuroscience 1999;92(3):1043-9
bradykinin, Gly(6)  0   Bradykinin/*analogs & derivatives. Am J Physiol 1999 Feb;276(2 Pt 1):L341-50
bradykinin, Tyr(Me)8  0   Bradykinin/*analogs & derivatives. Am J Physiol 1998 Aug;275(2 Pt 1):L322-9
bradykinin, Met(1,5)  0   Bradykinin/*analogs & derivatives. Peptides 1998;19(4):635-41
bradykinin, Trp(5)-Leu(8)  0   Bradykinin/*analogs & derivatives. Am J Physiol 1997 Feb;272(2 Pt 2):R710-7
bradykinin, desArg(9)-Hyp(3)  0   Bradykinin/*analogs & derivatives. Anal Biochem 1997 Mar 1;246(1):15-9
HOE 890307  0   Bradykinin/*analogs & derivatives. Pflugers Arch 1996;432(3 Suppl):R99-106
methionyl-lysyl-bradykinin-serine  0   Bradykinin/*analogs & derivatives. Immunopharmacology 1996 May;32(1-3):76-9
bradykinin, Ile(10)-Tyr(11)  0   Bradykinin/*analogs & derivatives. Gen Pharmacol 1996 Jul;27(5):787-94
bradykinin, Tyr(8)  0   Bradykinin/*analogs & derivatives. J Biol Chem 1996 Nov 1;271(44):27382-7
N-bromoacetylbradykinin  0   Bradykinin/*analogs & derivatives. RNA 1996 Oct;2(10):982-94
bradykinin, Arg(0)-Trp(5)-Leu(8)  0   Bradykinin/*analogs & derivatives. Peptides 1996;17(3):531-7
B 9340  0   Bradykinin/*analogs & derivatives Bradykinin/antagonists & inhibitors. J Med Chem 1996 Mar 15;39(6):1281
casoxin D  0   *Oligopeptides Bradykinin/agonists. Biosci Biotechnol Biochem 1995 Nov;59(11):2056-9
bradykinin, cyclo-N(epsilon)-Lys  0   Bradykinin/*analogs & derivatives. Int J Pept Protein Res 1995 May;45(5):459-65
bradykinin, Leu(8)  0   Bradykinin/*analogs & derivatives. Br J Pharmacol 1995 May;115(2):368-72
bradykinin, Trp(5)  0   Bradykinin/*analogs & derivatives. Peptides 1995;16(3):485-9
S 16118  0   Bradykinin/*analogs & derivatives. J Pharmacol Exp Ther 1995 Jun;273(3):1071-7
bradykinin, 4-iodo-Phe(5)  159694-13-0   Bradykinin/*analogs & derivatives Iodine Radioisotopes. Mol Pharmacol 1994 Nov;46(5):949-56
RMP 7  159768-75-9 L-Prolinamide, L-arginyl-L-prolyl-trans-4-hydroxy-L-prolyl-3-(2-thienyl)-L-alanylglycyl-L-seryl-N-02-004-0((((aminoiminomethyl)amino)-1-carboxybutyl)amino)-1-0(((4-methoxyphenyl)methyl)ethyl)-, 0S-(R*,R*)  Bradykinin/*analogs & derivatives. J Neurosurg 1994 Nov;81(5):752-8
bradykinin, Ala(1)-Thr(6)  0   Bradykinin/*analogs & derivatives. Gen Comp Endocrinol 1994 May;94(2):273-8
rimonabant  158681-13-1   *Piperidines *Pyrazoles Bradykinin/antagonists & inhibitors Cannabinoids/antagonists & inhibitors Receptors, Cannabinoid/antagonists & inhibitors. FEBS Lett 1994 Aug 22;350(2-3):240-4
sapo, Phyllomedusa bicolor  0   Bradykinin/*analogs & derivatives Caerulein/*analogs & derivatives Drug Combinations. Toxicon 1993 Sep;31(9):1099-111
para-iodophenyl HOE 140  152221-57-3   Bradykinin/*analogs & derivatives Iodine Isotopes. Life Sci 1993;53(25):1879-86
NPC 17761  147333-13-9 Bradykinin, N2-D-arginyl-3-(trans-4-hydroxy-L-proline)-7-(trans-4-(phenylthio)-D-proline)-8-(L-(2alpha,3abeta,7abeta)-octahydro-1H-indole-2-carboxylic acid)  Bradykinin/*analogs & derivatives. Eur J Pharmacol 1993 Aug 3;239(1-3):227-9
arginyl-prolyl-proline  23815-91-0   *Oligopeptides Bradykinin. Jpn J Pharmacol 1992 Oct;60(2):111-9
bradykinin (1-5)  23815-89-6   *Bradykinin *Peptide Fragments. Jpn J Pharmacol 1992 Oct;60(2):111-9
HOE 140, desArg(10)  138680-92-9   *Tetrahydroisoquinolines Bradykinin/*analogs & derivatives. Agents Actions Suppl 1992;38 ( Pt 2):406-13
bradykinin-Leu, Met-Ile-Ser  0   Bradykinin/*analogs & derivatives. Agents Actions Suppl 1992;38 ( Pt 3):248-57
bradykinin, acetyl-Arg-Hyp(3)-Phe(7)-Leu(8)  135705-19-0   Bradykinin/*analogs & derivatives. Agents Actions Suppl 1992;38 ( Pt 3):149-55
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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