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Asparaginase

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Definition: A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.     
Pharmacological Action Antineoplastic Agents 		Other names medac, Asparaginase; Rh+¦ne Poulenc Rorer Brand of Asparaginase; Deaminase, Asparagine; Asparaginase medac Brand; Asparaginase Speywood Brand; Asparaginase Sanfer Brand; Asparaginase Merck Brand; Asparaginase Ispen Brand; Asparaginase Christiaens Brand; Asparaginase Bellon Brand; Asparaginase Bayer Brand; medac Brand of Asparaginase; Speywood Brand of Asparaginase; Sanfer Brand of Asparaginase; Rh+¦ne-Poulenc Rorer Brand of Asparaginase; Paronal; Merck Brand of Asparaginase; Leunase; Kidrolase; Ispen Brand of AsparaginaseDrugs* : ELSPAR
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ALL-BFM-95 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Daunorubicin Prednisolone Vincristine 6-Mercaptopurine. Orv Hetil. 2005 Jan 9;146(2):75-80
PETHEMA ALL-96 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Daunorubicin Prednisolone Vincristine. Cancer Genet Cytogenet 2003 Jan 1;140(1):58-61
ASRGL1 protein, human  EC 3.5.1.-   *Asparaginase *Autoantigens. Mol Reprod Dev 2002 Jun;62(2):233-47
Asrgl1 protein, rat  EC 3.5.1.1   *Asparaginase *Autoantigens. Mol Reprod Dev 2002 Jun;62(2):233-47
Berlin-Frankfurt-Muenster protocol II  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Thioguanine Vincristine. Blood 2002 Jul 15;100(2):420-6
DFCI 95-01 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Dexamethasone Doxorubicin. Med Pediatr Oncol 2002 Jul;39(1):44-6
Stanford-NCOG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Doxorubicin Prednisolone Vincristine. Ann Hematol 2001 Nov;80(11):647-52
TGAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Polyethylene Glycols Thioguanine. Cancer Chemother Pharmacol 2001 Aug;48(2):123-33
MAPO protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Methotrexate Prednisone Vincristine. Leukemia 2001 Jun;15(6):898-902
ADA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Daunorubicin. Leukemia 2001 Jun;15(6):898-902
DFCI 91-01 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Dexamethasone Doxorubicin. Blood 2001 Mar 1;97(5):1211-8
ALL-VI protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Dexamethasone Vincristine. Leukemia 2000 Apr;14(4):688-95
VEPA-L protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Doxorubicin Methotrexate Prednisolone Vincristine. Jpn J Clin Oncol 1999 Jul;29(7):340-8
ACOPA II protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Doxorubicin Prednisone Vincristine. J Vet Intern Med 1997 Nov-Dec;11(6):333-9
MLL-93 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Leucovorin Cyclophosphamide Cytarabine Dexamethasone Etoposide Hydrocortisone Hydroxyurea Methotrexate Mitoxantrone. Leuk Res 1997 Sep;21(9):811-5
AIEOP 8703 protocol  0   Asparaginase *Antineoplastic Combined Chemotherapy Protocols Leucovorin Daunorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. Blood 1997 Aug 1;90(3):1226-32
PM-asparaginase  EC 3.5.1.-   *Asparaginase *Polyethylene Glycols. Leukemia 1997 Apr;11 Suppl 3:408-9
POG 8602 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Hydrocortisone Methotrexate Prednisone Vincristine 6-Mercaptopurine. Blood 1990 Jul 1;76(1):117-22
FRALLE 93 protocol  0   Asparaginase Vincristine *Antineoplastic Combined Chemotherapy Protocols Cortisone Anthracyclines. Blood 1996 Jul 1;88(1):302-8
MSK-NY-II protocol, modified  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Daunorubicin Methotrexate Prednisolone Vincristine. Med Pediatr Oncol 1996 Sep;27(3):139-44
BFM-86 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Methotrexate Prednisone Vincristine 6-Mercaptopurine. Blood 1996 Jun 15;87(12):5207-12
HR-3 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Dexamethasone Etoposide Methotrexate Prednisolone. Blood 1996 Apr 15;87(8):3143-50
HR-2 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Daunorubicin Dexamethasone Ifosfamide Methotrexate Prednisolone Thioguanine Vindesine. Blood 1996 Apr 15;87(8):3143-50
ALHR88 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Daunorubicin Methotrexate Prednisolone Vincristine. Med Pediatr Oncol 1996 Jan;26(1):10-9
AL851 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Daunorubicin Prednisolone Vincristine. Med Pediatr Oncol 1996 Jan;26(1):10-9
TSOP protocol  0   Asparaginase *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisolone Vincristine. Gematol Transfuziol 1993 May;38(5):6-10
palmitoyl-L-asparaginase  EC 3.5.1.-   *Asparaginase *Palmitates. Cancer Chemother Pharmacol 1994;34(3):230-4
IVAP protocol  0   Asparaginase *Antineoplastic Combined Chemotherapy Protocols Prednisolone Vincristine Idarubicin. Semin Oncol 1993 Dec;20(6 Suppl 8):39-46
BFM-ALL 81 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Vincristine. Acta Haematol Pol 1993;24(2):131-8
DCVP-1-asp protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Daunorubicin Prednisolone Vincristine. Rinsho Ketsueki 1993 Mar;34(3):307-12
Stanford University protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Doxorubicin Methotrexate Prednisolone. Ann Oncol 1992 Dec;3(10):839-41
AIEOP protocol 8202  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Daunorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. Haematologica 1992 Sep-Oct;77(5):427-9
non-Hodgkin's lymphoma protocol 8503  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Daunorubicin Methotrexate Prednisolone Vincristine 6-Mercaptopurine Trimethoprim-Sulfamethoxazole Combination. Br J Haematol 1992 Oct;82(2):310-6
AIEOP acute lymphoblastic leukemia protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Daunorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. Haematologica 1992 Jan-Feb;77(1):49-53
DFCI 85-01 protocol  0   *Antineoplastic Combined Chemotherapy Protocols *Asparaginase. Am J Pediatr Hematol Oncol 1992 May;14(2):136-9
VAMA protocol  0   Cytarabine *Antineoplastic Combined Chemotherapy Protocols Asparaginase Methotrexate Teniposide. Haematologica 1991 Nov-Dec;76(6):479-84
LOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Prednisolone Vincristine. Ter Arkh 1991;63(7):109-11
ALL-1 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Prednisone Vincristine Idarubicin. Semin Hematol 1991 Jul;28(3 Suppl 4):72-5
monomethoxypolyethylene glycol-conjugated asparaginase  0   *Asparaginase *Polyethylene Glycols. Leuk Res 1991;15(6):525
GIMEMA LAL 0288 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Doxorubicin Prednisolone Vincristine. Haematologica 1990;75(6):567
LSA(2)L(2) protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Doxorubicin Prednisone Thioguanine Vincristine. Cancer Genet Cytogenet 1990;50(1):31
CART protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Daunorubicin Thioguanine. Pediatr Hematol Oncol 1986;3(1):1
UKALL X protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Daunorubicin Methotrexate Prednisolone Vincristine. Arch Dis Child 1990;65(3):252
VAA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Doxorubicin Vincristine. Hamatol Bluttransfus 1990;33:428
VCAA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Doxorubicin Vincristine. Cancer 1988;61(10):2042
LLA-IV-AR protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Methotrexate Prednisone Teniposide Vincristine. An Esp Pediatr 1987;27(5):331
LL-IV-81 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Prednisone Vincristine. An Esp Pediatr 1987;27(5):325
protocol 8001  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Hydrocortisone Methotrexate Prednisone Vincristine 6-Mercaptopurine. Am J Pediatr Hematol Oncol 1987;9(4):356
EMLP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Etoposide Methotrexate Prednisolone. Nippon Ketsueki Gakkai Zasshi 1986;49(7):1404
OPAL protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Doxorubicin Prednisolone Vincristine. Br J Haematol 1986;64(3):455
ABLE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Bleomycin. Rinsho Ketsueki 1986;27(2):252
PVDA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Daunorubicin Prednisone Vincristine. N Eng J Med 1986;315(5):273
New York protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Daunorubicin Methotrexate Prednisone Thioguanine Vincristine. J Clin Oncol 1986;4(5):744
COPAD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Doxorubicin Methotrexate Prednisone Vincristine. IARC Sci Publ 1985;(60):383
HEAVD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Dexamethasone Doxorubicin Vincristine. Hematol Oncol 1985;38(1):49
pegaspargase  0   *Asparaginase *Polyethylene Glycols Delayed-Action Preparations Enzymes, Immobilized.
Pharma Action Antineoplastic Agents 		Cancer Biochem Biophys 1984;7(2):175ONCASPAR
TRAMPCOL protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Daunorubicin Methotrexate Prednisolone Thioguanine Vincristine. Med Clin North Am 1984;68(3):713
MOPA-6 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Mechlorethamine Prednisolone Vincristine 6-Mercaptopurine. Hematol Oncol 1984;2(2):151
VPDA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Doxorubicin Prednisone Vincristine. Cancer Res 1983;43(11):5601
CCG-141 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Methotrexate Prednisone Vincristine 6-Mercaptopurine. Cancer 1983;51(6):1041
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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