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Thioguanine
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Definition
: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Pharmacological Action
Antimetabolites, Antineoplastic
Other names
6-
Thioguanine; Tioguanine GlaxoSmithKline Brand; ThioguaninGSK; Thioguanin GSK; 2 Amino 6 Purinethiol; 6 Thioguanine; Wellcome Brand of Thioguanine; Tioguanine; Tioguanina Wellcome; Thioguanine Tabloid; Thioguanine Monosodium Salt; Thioguanine Hemihydrate; Thioguanin-
GSK; Tabloid; Lanvis; GlaxoSmithKline Brand of Tioguanine; GlaxoSmithKline Brand of Thioguanine; Glaxo Wellcome Brand of Tioguanine; Glaxo Wellcome Brand of Thioguanine; 2-
Amino-
6-
Purinethiol
Drugs
*
:
THIOGUANINE
Substance
CAS Registry & name
Categories
Source
Drugs
*
2-
amino-
9-
(2-
(phosphonomethoxy)ethyl)-
6-
sulfanylpurine
0
Thioguanine/*analogs & derivatives.
Nucleic Acids Symp Ser (Oxf) 2008;(52):671-2
N2,3-
etheno-
6-
thioguanine
0
Thioguanine/*analogs & derivatives.
J Chromatogr B Analyt Technol Biomed Life Sci 2008 Mar 15;864(1-2):149-55
guanine-
6-
thioguanine
0
Guanine/*analogs & derivatives
Thioguanine/*analogs & derivatives.
DNA Repair (Amst) 2007 Mar 1;6(3):344-54
POG-
8498 protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Azacitidine
Cytarabine
Daunorubicin
Etoposide
Methotrexate
Prednisone
Thioguanine
Vincristine
6-Mercaptopurine.
Pediatr Blood Cancer 2007 Mar;48(3):262-7
NSC35866
0
Thioguanine/*analogs & derivatives.
Cancer Res 2005 Aug 15;65(16):7462-9
Berlin-
Frankfurt-
Muenster protocol II
0
*Antineoplastic Combined Chemotherapy Protocols
Asparaginase
Cyclophosphamide
Cytarabine
Dexamethasone
Doxorubicin
Thioguanine
Vincristine.
Blood 2002 Jul 15;100(2):420-6
TGAP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Asparaginase
Cytarabine
Polyethylene Glycols
Thioguanine.
Cancer Chemother Pharmacol 2001 Aug;48(2):123-33
TPDCV protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Lomustine
Mitolactol
Procarbazine
Thioguanine
Vincristine.
Neuro-oncol 2000 Jan;2(1):22-8
8-
hydroxythioguanine
0
Thioguanine/*analogs & derivatives.
J Pharmacol Exp Ther 1999 Nov;291(2):870-4
TPDC-
FuHu protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Fluorouracil
Hydroxyurea
Lomustine
Mitolactol
Procarbazine
Thioguanine.
J Clin Oncol 1997 Mar;15(3):1063-70
DAT-
COAP regimen
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Cytarabine
Daunorubicin
Prednisone
Thioguanine
Vincristine.
Leuk Res 1996 Nov-Dec;20(11-12):987-8
BF-
9 protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Daunorubicin
Etoposide
Mitoxantrone
Thioguanine.
Eur J Obstet Gynecol Reprod Biol 1995 Dec;63(2):139-41
DCTER protocol
0
Etoposide
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Daunorubicin
Dexamethasone
Thioguanine.
Blood 1996 Jun 15;87(12):4979-89
HR-
2 protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Asparaginase
Daunorubicin
Dexamethasone
Ifosfamide
Methotrexate
Prednisolone
Thioguanine
Vindesine.
Blood 1996 Apr 15;87(8):3143-50
ETI protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Etoposide
Thioguanine
Idarubicin.
Leukemia 1994 Jan;8(1):11-5
HATP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Doxorubicin
Harringtonines
Prednisone
Thioguanine.
Chung Hua Nei Ko Tsa Chih 1993 Jul;32(7):470-2
PACET protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Etoposide
Lomustine
Prednisolone
Thioguanine.
Eur J Cancer 1993;29A(2):190-2
DATV regimen
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Daunorubicin
Thioguanine
Vincristine.
Chung Hua Nei Ko Tsa Chih 1992 Mar;31(3):146-8
VATA protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Doxorubicin
Etoposide
Thioguanine.
Sangre (Barc) 1991 Oct;36(5):427-30
6-
thioguainine disulfide
90920-73-3
Thioguanine/*analogs & derivatives.
Biochem J 1991;275(Pt 1):29
LSA(2)L(2) protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Asparaginase
Cyclophosphamide
Cytarabine
Doxorubicin
Prednisone
Thioguanine
Vincristine.
Cancer Genet Cytogenet 1990;50(1):31
CART protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Asparaginase
Cytarabine
Daunorubicin
Thioguanine.
Pediatr Hematol Oncol 1986;3(1):1
HAT regimen
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Harringtonines
Thioguanine.
Chung Hua Nei Ko Tsa Chih 1990;29(1):22
D(A)AT protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Daunorubicin
Doxorubicin
Thioguanine.
Chung Hua Nei Ko Tsa Chih 1990;29(1):22
6-
(decyldithio)-
1H-
purin-
2-
amine
78263-87-3
Thioguanine/*analogs & derivatives
Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors.
Biochem Pharmacol 1990;39(9):1484
6-
(phenyldithio)-
1H-
purin-
2-
amine
2959-10-6
Thioguanine/*analogs & derivatives
Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors.
Biochem Pharmacol 1990;39(9):1484
MI-
MIV maintenance protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Cytarabine
Thioguanine.
Hamatol Bluttransfus 1990;33:261
PATCO protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Cytarabine
Prednisolone
Thioguanine
Vincristine.
Cancer 1989;63(8):1457
ATA protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Amsacrine
Cytarabine
Thioguanine.
Cancer Chemother Pharmacol 1988;21(1):68
6-
thio-
3-
deazaguanine
52605-85-3
Thioguanine/*analogs & derivatives.
Cancer Res 1987;47(7):1863
BFM 78 protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Cytarabine
Doxorubicin
Methotrexate
Prednisone
Thioguanine
Vincristine.
Med Oncol Tumor Pharmacother 1985;2(1):17
POCAL protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Doxorubicin
Prednisolone
Thioguanine
Vincristine.
Scand J Haematol 1986;37(2):130
New York protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Asparaginase
Cyclophosphamide
Cytarabine
Daunorubicin
Methotrexate
Prednisone
Thioguanine
Vincristine.
J Clin Oncol 1986;4(5):744
HOAGP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Harringtonines
Prednisone
Thioguanine
Vincristine.
Chung Hua I Hsueh Tsa Chih 1985;65(10):590
9-
(n-
butyl)-
6-
thioguanine
30546-08-8
Thioguanine/*analogs & derivatives.
Cancer Res 1986;46(1):137
DATOP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Daunorubicin
Prednisone
Thioguanine
Vincristine.
Sangre (Barc) 1984;29(6):987
RATE protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Daunorubicin
Podophyllotoxin
Thioguanine.
J Clin Pathol 1984;37(11):1259
TAPA protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Doxorubicin
Prednisone
Thioguanine.
Gac Med Mex 1984;120(4):145
TRAMPCOL protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Asparaginase
Cyclophosphamide
Cytarabine
Daunorubicin
Methotrexate
Prednisolone
Thioguanine
Vincristine.
Med Clin North Am 1984;68(3):713
ACT protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Doxorubicin
Thioguanine.
J Clin Oncol 1984;2(4):253
BACT protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Carmustine
Cyclophosphamide
Cytarabine
Thioguanine.
Eur J Cancer Clin Oncol 1983;19(10):1371
TRAMPCO protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Cytarabine
Daunorubicin
Methotrexate
Prednisolone
Thioguanine
Vincristine.
Scand J Haematol 1983;31(5):403
DAT protocol 1
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Daunorubicin
Thioguanine.
Onkologie 1983;6(4):179
TACC protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Cytarabine
Lomustine
Thioguanine.
Presse Med 1983;12(31):1917
COATA protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Doxorubicin
Thioguanine
Vincristine.
Tumori 1983;69(3):239
TOAP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Prednisolone
Thioguanine
Vincristine.
Tumori 1983;69(3):239
DCTP regimen
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Daunorubicin
Prednisolone
Thioguanine.
Rinsho Ketsueki 1982;23(11):1681
L-
6 protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Carmustine
Cyclophosphamide
Cytarabine
Daunorubicin
Hydroxyurea
Methotrexate
Thioguanine
Vincristine.
Cancer 1982;50(8):1462
CT protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cytarabine
Thioguanine.
Aust NZ J Med 1982;12(3):238
6-
methylthioguanine
1198-47-6
Thioguanine/*analogs & derivatives.
Eur J Pharmacol 1982;81(3):505
palladium thioguanine
0
*Organometallic Compounds
Thioguanine/*analogs & derivatives
Palladium.
Br J Cancer 38(2):325;1978
1-
deaza-
6-
thioguanine
60282-76-0
Thioguanine/*analogs & derivatives.
J Org Chem 41(24):3784;1976