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Mechlorethamine

More information in Books or onNLM PubMed
Definition: A vesicant and necrotizing irritant destructive to mucous membranes. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage.     
Pharmacological Action Alkylating Agents; Antineoplastic Agents, Alkylating; Chemical Warfare Agents; Irritants 		Other names Nitrogen Mustard N-Oxide; Nitrogen Mustard; Mustine; Mechlorethamine Oxide; Chlormethine; Chlorethazine; Oxide, Mechlorethamine; Nitrogen Mustard N Oxide; NSC762; NSC10107; NSC 762; NSC 10107; N-Oxide, Nitrogen Mustard; N-Oxide, Mechlorethamine Hydrochloride; N-Oxide, Mechlorethamine; Mechlorethamine Hydrochloride N Oxide; Mechlorethamine N Oxide; Hydrochloride, Mechlorethamine; Hydrochloride N-Oxide, Mechlorethamine; NitrominDrugs* : MUSTARGEN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MOPPEBVCAD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin/*analogs & derivatives Lomustine Mechlorethamine Melphalan Prednisone Procarbazine Vinblastine Vincristine Vindesine. J Clin Oncol. 2005 Dec 20;23(36):9198-207
AKO4 compound  0   Mechlorethamine/*analogs & derivatives. Leuk Res 2005 May;29(5):565-72
Stanford V protocol  0   Bleomycin *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Etoposide Mechlorethamine Prednisone Vinblastine Vincristine. J Clin Oncol 1995 May;13(5):1080-8
4-(methylsulfinyl)phenyl nitrogen mustard  141612-08-0   *Sulfoxides Mechlorethamine/*analogs & derivatives. J Med Chem 1992 May 29;35(11):2137-9
ProMACE-MOPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Mechlorethamine Methotrexate Prednisone Procarbazine Vincristine. J Clin Oncol 1991;9(1):25
MOPP-ABV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin Mechlorethamine Prednisone Procarbazine Vinblastine Vincristine. Semin Hematol 1988;25(2 Suppl 2):34
MOMK protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin/analogs & derivatives Mechlorethamine Methotrexate Vincristine. Chung Hua Chung Liu Tsa Chih 1986;8(6):470
MOFK protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin/analogs & derivatives Fluorouracil Mechlorethamine Vincristine. Chung Hua Chung Liu Tsa Chih 1986;8(6):470
MOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mechlorethamine Procarbazine Vincristine. Int Radiat Oncol Biol Phys 1985;11(2):349
MADDOC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Dacarbazine Doxorubicin Mechlorethamine Vincristine. Radiother Oncol 1985:2(3):189
MVVPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mechlorethamine Prednisone Procarbazine Vinblastine Vincristine. Med Clin North Am 1984;68(3):729
MOPA-6 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Mechlorethamine Prednisolone Vincristine 6-Mercaptopurine. Hematol Oncol 1984;2(2):151
MOPP-Bleo protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Mechlorethamine Prednisone Procarbazine Vincristine. Cancer 1983;51(8):1339
MOP-BAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin Mechlorethamine Prednisone Procarbazine Vincristine. Cancer 1983;51(8):1339
BACON protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin Lomustine Mechlorethamine Vincristine. Lille Med 1981;1(2):50
MABOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin Mechlorethamine Prednisone Vincristine. Haematologica (Pavia) 1982;67(5):718
MVPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mechlorethamine Prednisolone Procarbazine Vinblastine. Br J Clin Pharmacol 1980;9(5):511
MOPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mechlorethamine Prednisone Procarbazine Vincristine. Br Med J 3(5980):413;1975; Neoplasma 22(2):225;1975; Series Haematol 6(2):184;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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