Definition: An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Other names 11beta Hydroxysteroid Dehydrogenase Type 2; 11 beta Hydroxysteroid Dehydrogenase Type 2; 11beta-Hydroxysteroid Dehydrogenase Type 2; 11beta-HSD2 Reductase; 11 beta-Hydroxysteroid Dehydrogenase Type 2; 11 beta-HSD2; 11beta-HSD2
