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11-beta-Hydroxysteroid Dehydrogenase Type 1

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Definition: A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.      Other names 11beta Hydroxysteroid Dehydrogenase Type 1; 11beta HSD1 Reductase; 11beta-Hydroxysteroid Dehydrogenase Type 1; 11beta-HSD1 Reductase; 11beta-HSD1; 11 beta-Hydroxysteroid Dehydrogenase Type 1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
INCB 13739  0   *Sulfonamides 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors. Diabetes Care 2010 Jul;33(7):1516-22
4-(2-adamantan-1-yl-2-oxoethoxymethyl)-N,N-dimethylbenzamide  0   *Benzamides Adamantane/*analogs & derivatives 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors. ChemMedChem 2010 Jul 5;5(7):1026-44
2-(3-noradamantylamino)-1-thia-3-azaspiro(4.4)non-2-en-4-one  0   *Thiazoles Adamantane/*analogs & derivatives 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors. J Med Chem 2008 May 22;51(10):2933-43
2-(1-(2-fluorophenyl)ethylamino)-5-methyl-5-(trifluoromethyl)thiazol-4(5H)-one  0   *Thiazoles 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors. Chem Biol Drug Des 2008 Jan;71(1):36-44
compound A (octyltriazole)  0   *Triazoles 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors. Am J Physiol Endocrinol Metab 2007 Oct;293(4):E1045-52
N-(5-hydroxy-2-adamantyl)-2(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propionamide  0   *Piperazines Adamantane/*analogs & derivatives 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors. J Med Chem 2007 Jan 11;50(1):149-64
N-(5-hydroxy-2-adamantyl)-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)acetamide  0   *Piperazines Adamantane/*analogs & derivatives 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors. J Med Chem 2007 Jan 11;50(1):149-64
3-(1-adamantyl)-6,7,8,9-tetrahydro-5H-(1,2,4)triazolo(4,3-a)azepine  0   *Azepines *Triazoles Adamantane/*analogs & derivatives 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors. J Exp Med 2005 Aug 15;202(4):517-27
HSD11B1 protein, human  EC 1.1.1.146   11-beta-Hydroxysteroid Dehydrogenase Type 1.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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