Definition: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
cocaine derivatives
Other names Hydrochloride, Cocaine; HCl, Cocaine; Cocaine Hydrochloride; Cocaine HCl
RTI 55 [ RTI-55,2-carbomethoxy-3-(4-iodophenyl)tropane,I(123)beta-CIT,2beta-carbomethoxy-3beta-(4-iodophenyl)tropane,3-(4-iodophenyl)tropane-2-carboxylic acid methyl ester,Iodine (125)-RTI-55,Iometopane,RTI 55, (11)C-labeled, (1R-(exo,exo))-isomer,RTI 55, (exo,exo)-isomer, (123)I-labeled,beta-CIT ] structure given in first source; a dopamine transporter ligand; RN given refers to (1R-(exo,exo))-isomer