src-Family Kinases (definition)

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ψ	src-Family Kinases

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Definition: A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.

Other names src Protein-Tyrosine Kinases; src Family Tyrosine Kinases; src Family Kinases; Tyrosine Kinases, src-Family; Tyrosine Kinases, src; Kinases, src Tyrosine; Kinases, src Protein-Tyrosine; src-Family Tyrosine Kinases; src Tyrosine Kinases; Kinases, src; src Kinases; Protein-Tyrosine Kinases, src

Substance	CAS Registry & name	Categories	Source
KX2 328	0	Quinazolines Benzodioxoles src-Family Kinases/antagonists & inhibitors.	Neurosci Res. 2011 Dec;71(4):348-54.
KX2 329	0	Acetamides Pyridines src-Family Kinases/antagonists & inhibitors.	Neurosci Res. 2011 Dec;71(4):348-54.
KX1 141	0	*Indoles src-Family Kinases/antagonists & inhibitors.	Neurosci Res. 2011 Dec;71(4):348-54.
Lyn protein, zebrafish	EC 2.7.10.2	src-Family Kinases Zebrafish Proteins.	Nature. 2011 Dec 1;480(7375):109-12.
6-chloro-2-methoxy-N-(2-methoxybenzyl)acridin-9-amine	0	*Aminoacridines src-Family Kinases/antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors.	Bioorg Med Chem 2011 Jun 1;19(11):3312-9
PD 173956	0	Pyridones Pyrimidines src-Family Kinases/antagonists & inhibitors.	Br J Pharmacol 2010 Jun;160(4):958-70
SI-83 compound	0	Pyrazoles Pyrimidines src-Family Kinases/antagonists & inhibitors.	FASEB J 2008 May;22(5):1560-71
(7-(2,6-dichlorophenyl)-5-methylbenzo(1,2,4)triazin-3-yl)-(4-(2-(1-oxypyrrolidin-1-yl)ethoxy)phenyl)amine	0	Pyrrolidines Triazines src-Family Kinases/antagonists & inhibitors.	Drug Metab Dispos 2007 Jun;35(6):929-36
(7-(2,6-dichlorophenyl)-5-methylbenzo(1,2,4)triazin-3-yl)-(4-(2-pyrrolidin-1-ylethoxy)phenyl)amine	0	Pyrrolidines Triazines src-Family Kinases/antagonists & inhibitors.	Drug Metab Dispos 2007 Jun;35(6):929-36
AP 23451	0	Phosphonic Acids Adenine/analogs & derivatives src-Family Kinases/antagonists & inhibitors.	Chem Biol Drug Des 2006 Jan;67(1):46-57
Frk protein, mouse	EC 2.7.1.112	*src-Family Kinases Neoplasm Proteins Proto-Oncogene Proteins c-fyn.
Frk protein, rat	EC 2.7.1.-	*src-Family Kinases Neoplasm Proteins Proto-Oncogene Proteins c-fyn.
KHDRBS2 protein, human	0	*RNA-Binding Proteins src-Family Kinases.
A 419259	0	Pyrimidines Pyrroles src-Family Kinases/antagonists & inhibitors.	Oncogene 2002 Nov 21;21(53):8075-88
hibarimicinone	0	Glycosides Naphthacenes src-Family Kinases/antagonists & inhibitors.	J Antibiot (Tokyo) 2002 Mar;55(3):270-8
hibarimicin B	0	Glycosides Naphthacenes src-Family Kinases/antagonists & inhibitors.	J Antibiot (Tokyo) 2002 Mar;55(3):270-8
Tom1L1 protein, mouse	EC 2.7.1.-	*src-Family Kinases.	J Biol Chem 2002 Jan 25;277(4):2385-952812-22
AP22188	0	*Diphosphonates src-Family Kinases/antagonists & inhibitors.	Bone 2001 Jan;28(1):54-64
AP21946	0	*Diphosphonates src-Family Kinases/antagonists & inhibitors.	Bone 2001 Jan;28(1):54-64
AP22409	0	*Diphosphonates src-Family Kinases/antagonists & inhibitors.	Bone 2001 Jan;28(1):54-64
4-((2,4-dichlorophenyl)aminio)-6-methoxy-7-(3-morpholin-4-ylpropoxy)-3-quinolinecarbonitrile	0	Morpholines Quinolines src-Family Kinases/antagonists & inhibitors.	J Med Chem 2001 Mar 1;44(5):822-33
SU 6657	0	Indoles Sulfonamides src-Family Kinases/antagonists & inhibitors.	Mol Cell Biol 2000 Dec;20(23):9018-27
SU 6656	0	Indoles Sulfonamides src-Family Kinases/antagonists & inhibitors.	Mol Cell Biol 2000 Dec;20(23):9018-27
AG 1879	0	*Pyrimidines src-Family Kinases/antagonists & inhibitors.	Proc Natl Acad Sci U S A 2000 Jul 18;97(15):8653-7
AP22161	0	*Benzoic Acids src-Family Kinases.	Chem Biol 2000 Mar;7(3):225-35
CGP 77675	0	Pyrimidines Pyrroles src-Family Kinases/antagonists & inhibitors.	Bone 1999 May;24(5):437-49
Xyk protein, Xenopus	EC 2.7.1.-	Egg Proteins src-Family Kinases *Xenopus Proteins.	Dev Biol 1999 May 15;209(2):308-20
Khdrbs2 protein, mouse	0	*RNA-Binding Proteins src-Family Kinases.	Mol Biol Rep. 2002 Dec;29(4):369-75; Proc Natl Acad Sci USA 1999 Mar 16;96(6):2710-5
laloo protein, Xenopus	0	src-Family Kinases Xenopus Proteins Signal Transduction.	Nature 1998 Aug 27;394(6696):904-8
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine	0	Pyrazoles Pyrimidines Antineoplastic Agents src-Family Kinases/antagonists & inhibitors. Pharma Action Enzyme Inhibitors	J Biol Chem 1996 Jan 12;271(2):695-701
WIN 61651	0	Piperazines Quinolines src-Family Kinases/antagonists & inhibitors.	J Enzym Inhib 1995;9(2):111-22
src-related intestinal kinase, mouse	EC 2.7.1.-	*src-Family Kinases Nuclear Proteins.	Oncogene 1995 Jan 19;10(2):349-57
SRMS protein, human	EC 2.7.1.-	*src-Family Kinases.	Mol Cell Biol 1994 Oct;14(10):6915-25
Spk-1 protein, Girardia tigrina	EC 2.7.1.-	*src-Family Kinases.	Oncogene 1994 Apr;9(4):1267-72
protein-tyrosine kinase p55(blk)	EC 2.7.1.-	*src-Family Kinases.	Immunol Rev 1993 Apr;132:163-86
lyn protein-tyrosine kinase	EC 2.7.10.2	*src-Family Kinases.	Proc Natl Acad Sci USA 1989;86(17):6538
proto-oncogene proteins c-fgr	EC 2.7.1.112	Proto-Oncogene Proteins src-Family Kinases Antigens, Neoplasm Tumor Markers, Biological.	Proc Natl Acad Sci USA 1987;84(13):4480

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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