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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

More information in Books or onNLM PubMed
Definition: This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.      Other names lck, Proto-Oncogene Protein; c-lck, Proto-Oncogene Protein; Proto Oncogene Protein lck; Proto Oncogene Protein c lck; Protein lck, Proto-Oncogene; Protein c-lck, Proto-Oncogene; Kinase, lck; Proto-Oncogene Protein lck; Proto-Oncogene Protein c-lck; p56 lck; lck Kinase; Protein Tyrosine Kinase p56(lck)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide  0   *Benzamides *Quinazolines Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/antagonists & inhibitors. J Med Chem 2006 Sep 21;49(19):5671-86
4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(2-(1-methylpiperidin-4-yloxy)-5-(trifluoromethyl)phenyl)benzamide  0   *Benzamides *Quinazolines Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/antagonists & inhibitors. J Med Chem 2006 Sep 21;49(19):5671-86
2,6-dimethylphenyl 2-((3,5-bis(methyloxy)-4-((3-(4-methyl-1-piperazinyl)propyl)oxy)phenyl)amino)-4-pyrimidinyl(2,4-bis(methyloxy)phenyl)carbamate  0   *Carbamates *Pyrimidines Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/antagonists & inhibitors. J Med Chem 2006 Aug 10;49(16):4981-91
stypoquinonic acid  0   *Naphthalenes *Quinones Lymphocyte Specific Protein Tyrosine Kinase p56(lck). J Nat Prod 1999 Jun;62(6):927-30
A 125800  0   *Thiazoles Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/antagonists & inhibitors. Arch Biochem Biophys 1999 Apr 1;364(1):19-29

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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