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src Homology Domains

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Definition: Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.      Other names src Homology Domain; SH3 Domains; SH2 Domains; SH1 Domains; SH Domain; Homology Domains, src; Homology Domain, src; src Homology Region 2 Domain; SH3 Domain; SH2 Domain; SH1 Domain; SH Domains
 
SubstanceCAS Registry & nameCategoriesSource
melanoma inhibitory activity protein 2, mouse  0   *Tumor Suppressor Proteins src Homology Domains. Gut. 2008 Feb;57(2):243-51.
Lsb3 protein, S cerevisiae  0   *Carrier Proteins *Saccharomyces cerevisiae Proteins src Homology Domains. PLoS Biol 2009 Oct;7(10):e1000218
Sh3gl3 protein, zebrafish  0   *Nerve Tissue Proteins *Zebrafish Proteins src Homology Domains. PLoS One 2009;4(3):e4994
IMP2 protein, S pombe  0   *Cytoskeletal Proteins *Schizosaccharomyces pombe Proteins src Homology Domains. J Cell Biol 2009 Jan 12;184(1):113-27
Nphp1 protein, mouse  0   *Carrier Proteins src Homology Domains. J Am Soc Nephrol 2000 Feb;11(2):270-82
TARSH protein, mouse  0   *Carrier Proteins src Homology Domains. Biochem Biophys Res Commun 2005 Apr 15;329(3):1031-8
Sh3md4 protein, mouse  0   *Carrier Proteins src Homology Domains.
endophilin 3, rat  0   *Nerve Tissue Proteins src Homology Domains. Cell Mol Neurobiol 2006 Jul-Aug;26(4-6):679-93
vinexin, rat  0   *Adaptor Proteins, Signal Transducing src Homology Domains. FEBS Lett 2006 Jul 24;580(17):4288-95
Eat2b protein, mouse  0   *Adaptor Proteins, Signal Transducing src Homology Domains. Nat Immunol 2005 Oct;6(10):1002-10
Eat2a protein, mouse  0   *Adaptor Proteins, Signal Transducing src Homology Domains. Immunogenetics 2006 Feb;58(1):15-25
HSH2 protein, mouse  0   *Adaptor Proteins, Signal Transducing src Homology Domains. J Immunol 2006 Apr 1;176(7):4163-72
endophilin A1 protein, mouse  0   *Adaptor Proteins, Signal Transducing src Homology Domains. J Mol Biol 2005 Aug 19;351(3):653-61
Ptpns1 protein, mouse  0   *Receptors, Immunologic src Homology Domains.
Tns3 protein, mouse  EC 3.1.3.16   *Phosphoprotein Phosphatases src Homology Domains. Dev Biol 2005 Mar 15;279(2):368-17
Sh2d1a protein, mouse  0   *Intracellular Signaling Peptides and Proteins src Homology Domains.
Sh3kbp1 protein, mouse  0   *Neoplasm Proteins *Nerve Tissue Proteins src Homology Domains.
Mona protein, mouse  0   *Adaptor Proteins, Signal Transducing src Homology Domains.
Sh3gl2 protein, mouse  0   *Adaptor Proteins, Signal Transducing src Homology Domains.
Chef-1 protein, Xenopus  0   *Xenopus Proteins *Intracellular Signaling Peptides and Proteins src Homology Domains. Gene Expr Patterns 2004 Oct;4(6):719-24
FCHSD1 protein, human  0   *Carrier Proteins *Membrane Proteins src Homology Domains. Int J Mol Med 2004 May;13(5):749-54
Eve-1 protein, human  0   *Adaptor Proteins, Signal Transducing src Homology Domains. J Biol Chem 2004 Oct 1;279(40):41950-9
Sh2bpsm1 protein, rat  0   *Carrier Proteins src Homology Domains.
Stam protein, mouse  0   *Phosphoproteins *Adaptor Proteins, Signal Transducing *Endosomal Sorting Complexes Required for Transport Signal Transduction src Homology Domains.
Stam2 protein, mouse  0   *Phosphoproteins *Adaptor Proteins, Signal Transducing *Endosomal Sorting Complexes Required for Transport Signal Transduction src Homology Domains.
NPHP4 protein, human  0   *Proteins src Homology Domains.
Sh2d1b1 protein, mouse  0   *Adaptor Proteins, Signal Transducing src Homology Domains.
Pex13 protein, mouse  0   *Membrane Proteins src Homology Domains.
LNK protein, human  0   *Proteins Signal Transduction src Homology Domains.
Lnk protein, mouse  0   *Intracellular Signaling Peptides and Proteins Signal Transduction src Homology Domains.
Sla protein, rat  0   *Proto-Oncogene Proteins pp60(c-src) *Adaptor Proteins, Signal Transducing src Homology Domains.
SLA protein, human  0   *Proto-Oncogene Proteins pp60(c-src) *Adaptor Proteins, Signal Transducing src Homology Domains.
SH3TC2 protein, human  0   *Proteins src Homology Domains. Am J Hum Genet 2003 Nov;73(5):1106-19
Aps protein, mouse  0   *Adaptor Proteins, Signal Transducing Protein-Tyrosine Kinases src Homology Domains.
STAMBP protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport src Homology Domains. Trends Biochem Sci. 2007 Dec;32(12):561-73
Sla2 protein, mouse  0   *Proto-Oncogene Proteins pp60(c-src) *Adaptor Proteins, Signal Transducing src Homology Domains.
DAPP1 protein, human  0   *Adaptor Proteins, Signal Transducing src Homology Domains.
SCAM-1 protein, human  0   *Muscle Proteins *Adaptor Proteins, Signal Transducing Vinculin src Homology Domains.
NCKIPSD protein, human  0   *Muscle Proteins *Adaptor Proteins, Signal Transducing src Homology Domains.
Shc3 protein, rat  0   *Shc Signaling Adaptor Proteins src Homology Domains.
Shc3 protein, mouse  0   *Shc Signaling Adaptor Proteins src Homology Domains.
Dbnl protein, rat  0   *Microfilament Proteins *src Homology Domains.
Dbnl protein, mouse  0   *Microfilament Proteins *src Homology Domains.
EAST protein, human  0   *Phosphoproteins Signal Transduction src Homology Domains.
Sh3bp2 protein, mouse  0   *Adaptor Proteins, Signal Transducing src Homology Domains.
SHD protein, human  0   *Proto-Oncogene Proteins src Homology Domains.
FCHSD2 protein, human  0   *Carrier Proteins *Membrane Proteins src Homology Domains. Oncogene 2003 Nov 20;22(52);8422-31
SH3PXD2A protein, human  0   *Adaptor Proteins, Vesicular Transport src Homology Domains. Biochem Soc Trans 2003 Feb;31(Pt 1):25-8
Sh3d19 protein, mouse  0   *Carrier Proteins *Adaptor Proteins, Vesicular Transport src Homology Domains. J Dermatol Sci 2003 Feb;31(1):43-51
p70 Jak2-interacting protein, mouse  0   *Adaptor Proteins, Signal Transducing src Homology Domains. Mol Cell Biol 2002 Nov;22(21):7491-500
BEM1 protein, Candida albicans  0   *Fungal Proteins src Homology Domains. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2002 Sep;34(5):553-9
endophilin A, Drosophila  EC 2.3.1.-   *Acyltransferases *Drosophila Proteins Nerve Tissue Proteins src Homology Domains. EMBO J 2002 Apr 2;21(7):1661-72
HSH2D protein, human  0   *Adaptor Proteins, Signal Transducing src Homology Domains. Biochem Biophys Res Commun 2001 Nov 16;288(5):1078-86
Stambp protein, mouse  EC 3.4.99.-   *Endopeptidases *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport src Homology Domains. Mol Cell Biol 2001 Dec;21(24):8626-37
SLA2 protein, human  0   *Proto-Oncogene Proteins pp60(c-src) *Adaptor Proteins, Signal Transducing src Homology Domains. J Exp Med 2001 Nov 5;194(9):1263-76
HCCA2 protein, human  0   *Nerve Tissue Proteins Alzheimer Disease Leucine Zippers src Homology Domains. Brain Res Mol Brain Res 2001 Feb 19;87(1):1-11
phocein  0   *Membrane Proteins src Homology Domains. Mol Biol Cell 2001 May;12(3):663-73
spri protein, Drosophila  0   *Carrier Proteins *Drosophila Proteins src Homology Domains. Mech Dev 2001 Mar;101(1-2):259-62
SH3GLB1 protein, human  0   *Adaptor Proteins, Signal Transducing src Homology Domains. Genomics 2001 Jan 15;71(2):222-34; J Biol Chem 2001 Jun 8;276(23):20559-65
Sh3kbp1 protein, rat  0   *Neoplasm Proteins *Nerve Tissue Proteins src Homology Domains. EMBO J 2000 Aug 1;19(15):4015-25; Eur J Biochem 2002 Jul;269(14):3402-8; J Biol Chem 2000 Jun 23;275(25):19275-81
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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