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Leukotrienes

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Definition: A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.  eicosanoids; GEN or unspecified; prefer specifics; /biosyn /physiol permitted   
See Also Receptors, Leukotriene
Examples Leukotriene A4; Leukotriene B4; SRS-A
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
eoxin C4  0   *Leukotrienes. Proc Natl Acad Sci U S A 2008 Jan 15;105(2):680-5
cysteinyl-leukotriene  0   *Cysteine *Leukotrienes Inflammation Mediators.
Pharma Action Immunologic Factors 		Adv Exp Med Biol 1997;433:95-8
leukotriene E5  79695-14-0 7,9,11,14,17-Eicosapentaenoic acid, 6-((2-amino-2-carboxyethyl)thio)-5-hydroxy-, (5S-(5R*,6S*(S*),7E,9E,11Z,14Z,17Z))  *Leukotrienes. Prostaglandins 1991;41(1):29
5-hydroxy-6-(2-keto-3-thiopropionyl)-7,9,11,14-eicosatetraenoic acid  117675-20-4   *Leukotrienes. Biochem Biophys Res Commun 1988;155(3):1119
5,15-dihydroperoxyeicosatetraenoic acid  76964-60-8   *Lipid Peroxides *Leukotrienes. Biochem Biophys Res Commun 1987;149(3):1063
14,15-dihydroperoxyeicosatetraenoic acid  0   *Lipid Peroxides *Leukotrienes. Adv Prostaglandin Thromboxane Leukotriene Res 1987;17A:75
8,15-diHPETE  62054-47-1   *Lipid Peroxides *Leukotrienes. Adv Prostaglandin Thromboxane Leukotriene Res 1987;17B:1103
8-hydroperoxyeicosatetraenoic acid  100896-35-3   *Leukotrienes. J Biol Chem 1986;261(2):747
15-hydroperoxy-5,9,11,13-eicosatetraenoic acid  0   *Leukotrienes. FEBS Lett 1981;126(1):127
arachidonic acid 5-hydroperoxide  74581-83-2 6,8,11,14-Eicosatetraenoic acid, 5-hydroperoxy  *Leukotrienes. J Immunol 1980;125(1):163
15-hydroperoxy-5,8,11,13-eicosatetraenoic acid  67675-14-3 5,8,11,13-eicosatetraenoic acid, 15-hydroperoxy  *Lipid Peroxides *Leukotrienes.
Pharma Action Vasoconstrictor Agents ; Lipoxygenase Inhibitors 		Adv Prostaglandin Thromboxane Res 1:139;1976; Adv Prostaglandin Thromboxane Res 1980;6:149; Arch Int Pharmacodyn 1979;242(2):285; Arch Int Pharmacodyn 220:297;1976; Experientia 30(2):172;1974; Nature 273(5665):765;1978; Nippon Ronen Igakkai Zasshi 1980;17(1):70; Prostaglandins 1979;18(6):909
12-HPETE  67675-13-2 (S-(E,E,E))-12-hydroperoxy-5,8,10,14-eicosatetraenoic acid  *Leukotrienes.
Pharma Action Platelet Aggregation Inhibitors ; Vasoconstrictor Agents 		Biochem Biophys Res Commun 89(4):1273;1979; Proc Natl Acad Sci USA 1980;77(1):308; Prostaglandins 1979;18(6):909

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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