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Leukotriene B4

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Definition: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)  /biosyn /physiol permitted; DF: note short X ref    Other names 5,12-diHETE; 5,12-HETE; LTB4; Leukotriene B 4; B-4, Leukotriene; 5,12 diHETE; Leukotrienes B; Leukotriene B-4; Leukotriene B; 5,12 HETE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
10T024A compound  0   *Phenazines Leukotriene B4/antagonists & inhibitors Prostaglandin D2/antagonists & inhibitors. Biosci Biotechnol Biochem. 2011;75(10):2056-8.
LTB4R protein, human  0   *Receptors, Leukotriene B4 Leukotriene B4.
leukotriene B4 glucuronide  0   *Glucuronides Leukotriene B4/*analogs & derivatives. Clin Exp Allergy 2004 Aug;34(8):1262-9
LTB4R2 protein, human  0   *Receptors, Leukotriene B4 Leukotriene B4.
DPC11870-11  0   *Biphenyl Compounds *Oligopeptides *Pyridines *Tetrazoles Leukotriene B4/antagonists & inhibitors. J Nucl Med 2003 Jul;44(7);1087-91
Ltb4r2 protein, mouse  0   *Receptors, Leukotriene B4 Leukotriene B4. J Biol Chem 2000 Sep 1;275(35):27000-4; J Exp Med 2000 Aug 7;192(3):421-32
obtusatic acid  0   *Benzoates Leukotriene B4/antagonists & inhibitors. Eur J Med Chem 2000 Apr;35(4):405-11
hinokiresinol  17676-24-3   *Phenols *Lignans Leukotriene B4/antagonists & inhibitors. Planta Med 1999 May;65(4):391-2
A 93176  0   *Quinolines Leukotriene B4/antagonists & inhibitors Stereoisomerism. Adv Exp Med Biol 1997;433:91-4
3-hydroxyleukotriene B4  0   Leukotriene B4/*analogs & derivatives. J Pharmacol Exp Ther 1994 Dec;271(3):1514-9
SC 45694  120772-66-9 6-Heptenoic acid, 5-hydroxy-7-(4-(1-hydroxy-3-nonenyl)phenyl)-, monolithium salt  Leukotriene B4/*analogs & derivatives. J Pharmacol Exp Ther 1994 Mar;268(3):1493-8
12-oxoleukotriene B4  136696-10-1 6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (S-(E,Z,E,Z))  Leukotriene B4/*analogs & derivatives. J Biol Chem 1993 Aug 25;268(24):18128-35
12-methylleukotriene B3  148504-32-9   Leukotriene B4/*analogs & derivatives. Prostaglandins 1993 Apr;45(4):335-45
5,12-dihydroxy-6,8,14-eicosatrienoic acid  120904-46-3   Leukotriene B4/*analogs & derivatives. Biochem Biophys Res Commun 1990;170(1):23
20-trifluoromethylleukotriene B4  115178-97-7 6,8,10,14-Eicosatetraenoic acid, 20,20,20-trifluoro-5,12-dihydroxy-, (S-(R*,S*-(E,Z,E,Z)))  Leukotriene B4/*analogs & derivatives. Prostaglandins 1989;37(2):287
5,12,19-trihydroxy-6,8,10,14-eicosatetraenoic acid  117605-61-5   Leukotriene B4/*analogs & derivatives. Biochem Biophys Res Commun 1989;159(3):1283
20-aldehyde leukotriene B4  115609-68-2   Leukotriene B4/*analogs & derivatives. J Biol Chem 1988;263(17):7996
20-carboxy-leukotriene B4  83861-61-4   Leukotriene B4/*analogs & derivatives. Biochem Biophys Res Commun 1985;132(3):864
18-carboxy-19,20-dinorleukotriene B4  102674-12-4   Leukotriene B4/*analogs & derivatives. J Biol Chem 1986;261(12):5414
leukotriene B3  88099-35-8   Leukotriene B4/*analogs & derivatives. Arch Pharm (Weinheim) 1985;318(3):225
leukotriene B5  80445-66-5   Leukotriene B4/*analogs & derivatives Eicosapentaenoic Acid/*analogs & derivatives. Biochem Biophys Res Commun 1983;117(1):282
leukotriene B4 dimethylamide  83024-92-4 6,8,10,14-Eicosatetraenamide, 5,12-dihydroxy-N,N-dimethyl-, (S-(R*,S*-(E,Z,E,Z)))  Leukotriene B4/*analogs & derivatives. Biochem Biophys Res Commun 1982;106(3):741
5,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acid  79008-24-5 6,8,10,14-Eicosatetraenoic acid, 5,12,20-trihydroxy-, (S-(R*,R*-(E,E,Z,Z)))  Leukotriene B4/*analogs & derivatives. FEBS Lett 1981;128(2):329
14,15-leukotriene B4  77667-09-5 5,8,10,12-Eicosatetraenoic acid, 14,15-dihydroxy  Leukotriene B4/*analogs & derivatives. Biochem Biophys Res Commun 1981;99(3):976
8,15-leukotriene B4  77667-08-4 5,9,11,13-Eicosatetraenoic acid, 8,15-dihydroxy  Leukotriene B4/*analogs & derivatives. Biochem Biophys Res Commun 1981;99(3):976

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