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Leukotriene A4

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Definition: (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)  /biosyn /physiol permitted    Other names LTA4; Leukotriene A 4; Leukotrienes A; Leukotriene A-4; Leukotriene A
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
19-((2-azido-5-trimethylstannyl)benzoyloxy)leukotriene A(4)  0   *Organotin Compounds Leukotriene A4/*analogs & derivatives. Bioorg Med Chem Lett 2000 Apr 3;10(7):665-8
19-((2-azido-5-iodo)benzoyloxy)leukotriene A(4)  0   Leukotriene A4/*analogs & derivatives. Bioorg Med Chem Lett 2000 Apr 3;10(7):665-8
14,15-dehydroleukotriene A4  0   Leukotriene A4/*analogs & derivatives. Biochem J 1997 Nov 15;328( Pt 1):225-9
14,15-leukotriene A4  81918-96-9   Leukotriene A4/*analogs & derivatives. Eur J Biochem 1988;173(3):531
11,12-leukotriene A4  95722-34-2   Leukotriene A4/*analogs & derivatives. FEBS Lett 1987;213(1):169
leukotriene A methyl ester  75879-18-4   Leukotriene A4/*analogs & derivatives. FEBS Lett 1984;175(2):289
5,6-methanoleukotriene A4  83213-62-1 Cyclopropanebutanoic acid, 2-(1,3,5,8-tetradecatetraenyl)  Leukotriene A4/*analogs & derivatives. FEBS Lett 1982;143(1):13

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