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Cyclic GMP

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Definition: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)  /biosyn /physiol permitted; DF: CYCL GMP   
Examples Dibutyryl Cyclic GMP 		Other names Guanosine Cyclic 3',5'-Monophosphate; Cyclic-3',5'-Monophosphate, Guanosine; Cyclic Monophosphate, Guanosine; Cyclic 3',5'-Monophosphate, Guanosine; 3',5'-Monophosphate, Guanosine Cyclic; Guanosine Cyclic-3',5'-Monophosphate; Guanosine Cyclic Monophosphate; Guanosine Cyclic 3,5 Monophosphate; Monophosphate, Guanosine Cyclic; Guanosine Cyclic 3',5' Monophosphate; GMP, Cyclic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
8-nitroguanosine 3',5'-cyclic monophosphate  0   Cyclic GMP/*analogs & derivatives. Nat Chem Biol 2007 Nov;3(11):727-35
CPT-cGMP  0   Cyclic GMP/*analogs & derivatives. J Endocrinol. 2003 Apr;177(1):35-44
YKG9 protein, S cerevisiae  0   *Carrier Proteins *Saccharomyces cerevisiae Proteins Cyclic GMP Saccharomyces cerevisiae. EMBO J 2000 Oct 16;19(20):5288-99
(7-methoxycoumarin-4-yl)-methyl-caged 8-bromoguanosine cyclic 3',5'-monophosphate  0   Cyclic GMP/*analogs & derivatives. J Photochem Photobiol B 1999 Nov-Dec;53(1-3):91-102
8-bromo-beta-phenylethenoguanosine 3',5'-cyclic monophosphate  0   Cyclic GMP/*analogs & derivatives. J Am Soc Nephrol 1996 Jul;7(7):999-1005
Rp-8-bromoguanosine 3',5'-cyclic monophosphorothioate  0   Cyclic GMP/*analogs & derivatives Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors. J Vasc Res 1996 Sep-Oct;33(5):386-94
4,5-dimethoxy-2-nitrobenzyl-8-bromo-cGMP  177592-89-1   Cyclic GMP/*analogs & derivatives. Biochemistry 1996 Jun 18;35(24):7762-71
8-bromo-beta-phenyl-1,N(2)-ethenoguanosine 3',5'-cyclic monophosphorothioate  172806-21-2   *Thionucleotides Cyclic GMP/*analogs & derivatives Stereoisomerism Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors. Br J Pharmacol 1995 Dec;116(8):3110
N(1)-biotinyl-N(8)-(cGMP-succinyl)-1,8-diamino-3,6-dioxaoctane  0   Biotin/*analogs & derivatives Cyclic GMP/*analogs & derivatives. J Immunoassay 1995 Feb;16(1):37-53
8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate  0   *Thionucleotides Cyclic GMP/*analogs & derivatives Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Proc Natl Acad Sci U S A 1994 Dec 6;91(25):12086-90
2'-O-(4-benzoylbenzoyl)guanosine cyclic 3',5'-monophosphate  137154-74-6   Cyclic GMP/*analogs & derivatives 3',5'-Cyclic-GMP Phosphodiesterases/antagonists & inhibitors. J Med Chem 1994 Jul 22;37(15):2406-10
8-bromoguanosino-3',5'-cyclic monophosphorothioate  150418-07-8   *Thionucleotides Cyclic GMP/*analogs & derivatives. Arch Biochem Biophys 1993 Nov 1;306(2):383-90
8-(4-azidophenacyl)thio-cyclic GMP  149478-71-7   *Azides Cyclic GMP/*analogs & derivatives. Proc Natl Acad Sci U S A 1993 Jun 1;90(11):5369-73
dipalmitoyl cyclic guanosinemonophosphate  0   *Palmitates Cyclic GMP/*analogs & derivatives. J Physiol Pharmacol 1991 Dec;42(4):397-406
8-azidoguanosine cyclic monophosphate  99754-65-1   *Azides Cyclic GMP/*analogs & derivatives. Proc Natl Acad Sci USA 1990;87(6):2201
2'-dimethyl-tert-butylsilyl-N(2)-(N,N-dimethylamino)methylene-guanosine 3',5'-cyclic diethylphosphoramidate  126922-65-4   Cyclic GMP/*analogs & derivatives. Yao Hsueh Hsueh Pao 1989;24(10):726
n-butyl 2'-dimethyl-tert-butylsilyl-N(2)-(N,N-dimethylamino)methylene-guanosine 3,',5'-cyclic phosphate  126922-67-6   Cyclic GMP/*analogs & derivatives. Yao Hsueh Hsueh Pao 1989;24(10):726
bis(3',5')-cyclic diguanylic acid  61093-23-0   Cyclic GMP/*analogs & derivatives. J Bacteriol 1989;171(12):6649
8-((4-chlorophenyl)thio)cyclic-3',5'-GMP  54364-02-2   *Thionucleotides Cyclic GMP/*analogs & derivatives.
Pharma Action Platelet Aggregation Inhibitors 		J Neurosci 1988;8(4):1162
8-(2-carboxymethylthio)-cGMP  114115-66-1   Cyclic GMP/*analogs & derivatives. Eur J Biochem 1988;172(2):439
2'-methylanthraniloyl guanosine cyclic monophosphate  83707-15-7   *Anthranilic Acids Cyclic GMP/*analogs & derivatives. Anal Biochem 1987;162(1):291
8-(5-thioacetamidofluorescein)cyclic-GMP  99776-42-8   *Fluoresceins Cyclic GMP/*analogs & derivatives. Eur J Biochem 1985;153(1):49
carbocyclic guanosine monophosphate  97727-47-4   Cyclic GMP/*analogs & derivatives. Mol Pharmacol 1985;27(6):666
4,5-dimethoxy-2-nitrobenzyl cyclic GMP  92313-26-3 Guanosine, prepro- (human pheochromocytoma), (+-)  Cyclic GMP/*analogs & derivatives. Nature 1984;310(5972):74
2'-O-succinyl cyclic GMP  39118-26-8 guanosine cyclic 3',5'-(hydrogen phosphate) 2'-(3-carboxypropanoate)  Cyclic GMP/*analogs & derivatives. J Cyclic Nucleotide Res 1980;6(6):461
cyclic GMP-binding protein  0   *Carrier Proteins *Intracellular Signaling Peptides and Proteins Cyclic GMP Receptors, Cell Surface. J Biol Chem 255(2):620;1980
2'-deoxy cyclic GMP  13440-33-0 2'-deoxyguanosine cyclic 3',5'-(hydrogen phosphate)  Cyclic GMP/*analogs & derivatives. J Cyclic Nucleotide Res 4(6):463;1978
guanosine-3',5'-cyclic phosphorothioate  67736-26-9 Guanosine, cyclic 3',5'-(hydrogen phosphorothioate)  *Thionucleotides Cyclic GMP/*analogs & derivatives. FEBS Lett 91(2):182;1978
8-bromocyclic GMP  31356-94-2 8-bromoguanosine, cyclic 3',5'-(hydrogen phosphate)  Cyclic GMP/*analogs & derivatives Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors. Brain Res 166(1):113;1979; Endocrine Res Commun 4(6):329;1978; Exp Eye Res 27(4):387;1978; J Biol Chem 1980;255(4):1235; J Biol Chem 254(12):5321;1979; J Biol Chem 254(17):8554;1979; J Mol Cel Cardiol 10(6):573;1978; JPn J Pharmacol 1979;29(3):423; Klin Wochenschr 56(Suppl 1):51;1978
succinyl cyclic GMP-tyrosine methyl ester  61756-21-6 Guanosine, cyclic 3',5'-(hydrogen phosphate) 2'-(4-((1-((4-hydroxyphenyl)methyl)-2-methoxy-2-oxoethyl)amino)-4-oxobutanoate)  Cyclic GMP/*analogs & derivatives Tyrosine/*analogs & derivatives. Anal Biochem 77(2):429;1977
9-(beta-D-xylofuranosyl)guanine cyclic 3',5'-monophosphate  59668-85-8   Cyclic GMP/*analogs & derivatives. J Med Chem 19(8):1026;1976
9-beta-D-arabinofuranosylguanine cyclic 3',5'-phosphate  51821-84-2   *Arabinonucleotides *Cyclic GMP. J Med Chem 17(3):259;1974
guanosine 2',3'-cyclophosphorothioate  38557-85-6 Guanosine, cyclic 2',3'-(hydrogen phosphorothioate), (R)  *Thionucleotides Cyclic GMP/*analogs & derivatives. Biochemistry 11(19):3507;1972

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