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Heparin Cofactor II

More information in Books or onNLM PubMed
Definition: A sulfated plasma protein with a MW of approximately 66kDa that resembles ANTITHROMBIN III. The protein is an inhibitor of thrombin in plasma and is activated by dermatan sulfate or heparin. It is a member of the serpin superfamily.     
Pharmacological Action Antithrombins; Serine Proteinase Inhibitors 		Other names Serpin D1; Heparin Co Factor II; Protease Inhibitor Leuserpin 2; Heparin Cofactor 2; Heparin Co-Factor II; Leuserpin 2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Serpind1 protein, rat  0   *Heparin Cofactor II.
Serpind1 protein, mouse  0   *Heparin Cofactor II.
intimatan  0   Dermatan Sulfate/*analogs & derivatives Thrombin/antagonists & inhibitors Heparin Cofactor II/agonists. Thromb Res 2000 Sep 15;99(6):603-12
SERPIND1 protein, human  0   *Heparin Cofactor II. Nucleic Acids Res 1986;14(2):1073

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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