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Sulfhydryl Reagents
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Definition
: Chemical agents that react with SH groups. This is a chemically diverse group that is used for a variety of purposes. Among these are enzyme inhibition, enzyme reactivation or protection, and labelling.
do not confuse with SULFHYDRYL COMPOUNDS
See Also
Enzyme Inhibitors
Other names
Thiol Reagents; Sulfhydryl Compound Inhibitors; Sulfhydryl Compound Antagonists; SH-
Reagents; SH Reagents; Reagents, Thiol; Reagents, Sulfhydryl; Inhibitors, Sulfhydryl Compounds; Inhibitors, Sulfhydryl Compound; Compound Inhibitors, Sulfhydryl; Compound Antagonists, Sulfhydryl; Antagonists, Sulfhydryl Compounds; Antagonists, Sulfhydryl Compound; Sulfhydryl Compounds Inhibitors; Sulfhydryl Compounds Antagonists
Substances having this pharmacologic action:
p-Chloromercuribenzoic Acid
;
Diamide
;
Chloromercuribenzoates
;
Chloromercurinitrophenols
;
4-Chloromercuribenzenesulfonate
;
Arsenicals
;
Showdomycin
;
Mercuribenzoates
;
Dithioerythritol
;
Dithionitrobenzoic Acid
;
Hydroxymercuribenzoates
;
Ethylmaleimide
;
Cystamine
;
(2-sulfonatoethyl)methanethiosulfonate
;
(2-(trimethylammonium)ethyl)methanethiosulfonate
Substance
CAS Registry & name
Categories
Source
Drugs
*
2-
((methylsulfonyl)thio)ethyl (N-
(N,N-
dimethylamino)ethyl)carbamate
187592-54-7
*Carbamates
*Sulfones
Sulfhydryl Reagents.
Biochemistry 1997 Feb 11;36(6):1343-8
2-
nitro-
1-
(4,5-
dimethoxy-
2-
nitrophenyl)ethene
0
*Nitrobenzenes
beta-Galactosidase/antagonists & inhibitors
Sulfhydryl Reagents.
Biochim Biophys Acta 1996 Apr 16;1293(2):238-42
4-
acetamido-
4'-
((iodoacetyl)amino)stilbene-
2,2'-
disulfonate
0
*Stilbenes
Sulfhydryl Reagents.
FEBS Lett 1994 Dec 12;356(1):66-71
4-
(N,N-
dimethylaminosulfonyl)-
7-
(2-
chloroformylpyrrolidin-
1-
yl)-
2,1,3-
benzoxadiazole
150993-62-7
*Oxadiazoles
*Pyrrolidines
Sulfhydryl Reagents.
Biomed Chromatogr 1994 Mar-Apr;8(2):85-9
n-
octyl-
5-
dithio-
2-
nitrobenzoic acid
146019-29-6
*Disulfides
*Nitrobenzoates
Sulfhydryl Reagents.
Anal Biochem 1993 Feb 1;208(2):357-62
4-
bromomethyl-
3-
nitrobenzoic acid
55715-03-2
*Nitrobenzoates
Sulfhydryl Reagents.
Biochem Int 1992 Apr;26(5):943-51
8-
thiocyano-
adenosine triphosphate
139041-17-1
Adenosine Triphosphate/*analogs & derivatives
Sulfhydryl Reagents.
Biochemistry 1992 Feb 25;31(7):2107-13
3-
(2-
pyridyldithio)propionylarginylmonoiodotyrosine
138191-81-8
*Dipeptides
Sulfhydryl Reagents.
Anal Biochem 1991 Oct;198(1):165-73
3-
maleimidopropionylarginylmonoiodotyrosine
138191-82-9
*Dipeptides
Sulfhydryl Reagents.
Anal Biochem 1991 Oct;198(1):165-73
4,4'-
dimethoxytrityloxy-
S-
(2-
thio-
5-
nitropyridyl)-
2-
mercaptoethane
131384-76-4
*Pyridines
*Trityl Compounds
Sulfhydryl Reagents.
Anal Biochem 1990;189(2):173
S-
(bismaleimidoethyl ether)cysteine
124505-88-0
*Maleimides
Cysteine/*analogs & derivatives
Sulfhydryl Reagents.
Biochem J 1989;263(3):875
4-
(N,N-
dimethylaminosulfonyl)-
7-
fluoro-
2,1,3-
benzoxadiazole
98358-90-8 4-
Benzofurazansulfonamide, 7-
fluoro-
N,N-
dimethyl
*Oxazoles
*Sulfonamides
Sulfhydryl Reagents.
Analyst 1989;114(4):413
1-
(4-
chlorophenyl)-
4,4-
dimethyl-
5-
diethylamino-
1-
penten-
3-
one
121229-92-3
*Chlorobenzenes
*Ketones
Mannich Bases
Sulfhydryl Reagents.
Anal Biochem 1989;177(2):237
3-
bromopyruvamide
35293-21-1
*Pyruvates
Sulfhydryl Reagents.
Biomed Biochim Acta 1988;47(1):9
pyridyldithioethylamine
83578-21-6
*Disulfides
*Pyridines
Sulfhydryl Reagents.
Biochemistry 1988;27(3):848
phenyldichloroarsine
696-28-6
*Arsenicals
Sulfhydryl Reagents.
Arch Biochem Biophys 1987;257(2):293
4-
(hydroxybutyl)dichloroarsine
28440-95-1
*Arsenicals
Sulfhydryl Reagents.
Biochemistry 1987;26(3):863
benzophenone-
4-
iodoacetamide
76809-63-7
*Benzophenones
Sulfhydryl Reagents.
Proc Natl Acad Sci USA 1986;83(17):6392
(2-
nitroaniline-
N-
ethyldithio)-
2-
(pyridyl-
5-
thioureido-
N'-
(5-
fluorescein))
101613-93-8
*Fluoresceins
Thiourea/*analogs & derivatives
Sulfhydryl Reagents.
Anal Biochem 1986;153(2):336
4,4'-
diaminodiphenyldisulfide
722-27-0
*Aniline Compounds
Sulfhydryl Reagents.
Biochim Biophys Acta 1985;830(1):71
glutathione maleimide
137593-43-2
*Maleimides
Sulfhydryl Reagents.
J Biol Chem 1985;260(1):462
glutathione hexane maleimide
0
*Maleimides
Sulfhydryl Reagents.
Eur J Biochem 1983;135(1):41
N-
(4-
(2-
benzoxazolyl)phenyl)maleimide
16707-41-8
*Maleimides
Sulfhydryl Reagents.
J Chromatogr 1983;275(1):89
7-
fluorobenzo-
2-
oxa-
1,3-
diazole-
4-
sulfonate
84806-27-9 4-
Benzofurazansulfonic acid, 7-
fluoro-
, ammonium salt
*Fluorobenzenes
Sulfhydryl Reagents.
Pharma Action
Fluorescent Dyes
Anal Biochem 1983;128(2):471
warburganal
62994-47-2
*Sesquiterpenes
Allergens
Sulfhydryl Reagents.
Arch Dermatol Res 1982;274(3-4):277
methyl 2-
pyridyl disulfide
63434-91-3 Pyridine, 2-
(methyldithio)
*Pyridines
Sulfhydryl Reagents.
Anal Biochem 1982;122(2):274
3-
nitro-
2-
pyridyl disulfide
82650-28-0 Pyridine, 2-
(methyldithio)-
3-
nitro
*Pyridines
Sulfhydryl Reagents.
Anal Biochem 1982;122(2):274
tetramethylrhodamine iodoacetamide
81235-33-8 Xanthylium, 9-
(2-
carboxyphenyl)-
3,6-
bis(dimethylamino)-
, mono((iodoacetyl)amino) deriv., chloride
*Rhodamines
Sulfhydryl Reagents.
Pharma Action
Fluorescent Dyes
Arch Biochem Biophys 1982;216(1):133
4-
nitrobenzyl selenosulfuric acid
82571-50-4 Selenosulfuric acid, Se-
((4-
nitrophenyl)methyl) ester
*Nitrobenzenes
*Organoselenium Compounds
Sulfhydryl Reagents.
Biochem J 1982;201(2):305
benzylselenium sulfuric acid
82571-51-5 Selenosulfuric acid, Se-
(phenylmethyl) ester
*Organoselenium Compounds
Sulfhydryl Reagents.
Biochem J 1982;201(2):305
4-
chloro-
7-
sulfobenzofurazan
81377-14-2 4-
Benzofurazansulfonic acid, 7-
chloro-
, ammonium salt
*Benzoxazoles
Sulfhydryl Reagents.
Arch Biochem Biophys 1982;214(1):386
N-
(2,2,2-
trifluoroethoxycarbonyl)imidazole
81265-32-9 1H-
Imidazole-
1-
carboxylic acid, 2,2,2-
trifluoroethyl ester
*Imidazoles
Sulfhydryl Reagents.
Biochim Biophys Acta 1982;701(2):153
6,6'-
diselenobis-
(3-
nitrobenzoic acid)
80180-68-3 Benzoic acid, 2,2'-
diselenobis(5-
nitro)
Dithionitrobenzoic Acid/*analogs & derivatives
Sulfhydryl Reagents.
Anal Biochem 1981;117(1):94
4-
aminophenylarsenoxide
1122-90-3
*Arsenicals
Sulfhydryl Reagents.
Eur J Biochem 1981;118(3):541
mercury orange
3076-91-3
*Phenylmercury Compounds
Sulfhydryl Reagents.
Pol J Pharmacol 1980;32(4):557; Verh Anat Ges 69;249;1975
monobromobimane
71418-44-5 1H,7H-
pyrazolo(1,2-
a)pyrazole-
1,7-
dione, 3-
(bromomethyl)-
2,5,6-
trimethyl
*Bicyclo Compounds
Sulfhydryl Reagents.
Pharma Action
Fluorescent Dyes
Histochemistry 1980;68(3):309
N-
(beta-
iodoethyl)trifluoroacetamide
0
Trifluoroacetic Acid/*analogs & derivatives
Sulfhydryl Reagents.
Anal Biochem 1980;106(1):43
2-
chloromercuri-
4-
nitrophenol
24579-90-6
*Chloromercurinitrophenols
Sulfhydryl Reagents.
J Biol Chem 1980;255(15):7296
L589-
420
1431-30-7 2,3-
dichloro-
4-
(2-
ethylidinebutyryl)phenoxyacetic acid
*Glycolates
Sulfhydryl Reagents.
Can J Physiol Pharmacol 51(9):642;1973
ethylacetylacrylate
6742-53-6 4-
oxo-
2-
pentenoic acid, ethyl ester
*Acrylates
Sulfhydryl Reagents.
Biochim Biophys Acta 1980;621(2):338
methoxycarbonyl-
coenzyme A disulfide
72205-57-3 Coenzyme A, S-
(O-
methyl carbono(dithioperoxoate))
*Coenzyme A
Sulfhydryl Reagents.
J Biol Chem 254(23):11988;1979
N-
(methoxypolyethylene glycol)-
4-
hydroxymercuribenzamide
71861-55-7 Poly(oxy-
1,2-
ethanediyl), alpha-
(2-
((4-
(hydroxymercurio)benzoyl)amino)ethyl)-
omega-
methoxy