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RNA Replicase
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Definition
: An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)
Other names
RNA-
Dependent RNA Polymerase; Replicase, RNA; RNA Polymerase, RNA-
Directed; RNA Polymerase, RNA-
Dependent; RNA Directed RNA Polymerase; RNA Dependent RNA Polymerase; RNA-
Directed RNA Polymerase
Substance
CAS Registry & name
Categories
Source
Drugs
*
2-
(4-
((4-
(acetylamino)-
4'-
chloro-
(1,1'-
biphenyl)-
2-
yl)methoxy)phenyl)-
1-
cyclohexyl-
1H-
benzimidazole-
5-
carboxylic acid
0
*Acetamides
*Benzimidazoles
RNA Replicase/antagonists & inhibitors.
Antiviral Res. 2012 Jan;93(1):30-8.
2'-
deoxy-
2'-
spirocyclopropylcytidine
0
*Spiro Compounds
Cytidine/*analogs & derivatives
RNA Replicase/antagonists & inhibitors.
J Med Chem 2010 Nov 25;53(22):8150-60
6-
cyclopentyl-
6-
(2-
(2,6-
diethylpyridin-
4-
yl)ethyl)-
3-
((5,7-
dimethyl-
(1,2,4)triazolo(1,5-
a)pyrimidin-
2-
yl)methyl)-
4-
hydroxy-
5,6-
dihydropyran-
2-
one
0
*Pyrones
*Triazoles
RNA Replicase/antagonists & inhibitors.
J Med Chem 2009 Mar 12;52(5):1255-8
Nsp1 protein, SARS coronavirus
EC 2.7.7.48
*RNA Replicase
*Viral Nonstructural Proteins.
J Virol 2004 Dec;78(24):13600-12
RDR2 protein, Arabidopsis
EC 2.7.7.48
*RNA Replicase
*Arabidopsis Proteins.
Plant Cell 2006 Jul;18(7):1559-74
5-
((4-
bromophenyl)methyl)-
2-
phenyl-
5H-
imidazo(4,5-
c)pyridine
0
*Imidazoles
*Pyridines
RNA Replicase/antagonists & inhibitors.
J Virol 2006 Jan;80(1):149-60
5-
nitrocytidine
0
Cytidine/*analogs & derivatives
RNA Replicase/antagonists & inhibitors.
J Med Chem 2006 Oct 19;49(21):6166-9
RDR6 protein, Arabidopsis
EC 2.7.7.48
*RNA Replicase
*Arabidopsis Proteins.
Plant Cell Physiol 2006 Jul;47(7):853-63
2-
(4-
(4'-
chloro-
4-
(2-
oxopyrrolidin-
1-
yl)biphenyl-
2-
ylmethoxy)-
2-
fluorophenyl)-
1-
cyclohexyl-
1H-
benzimidazole-
5-
carboxylic acid
0
*Benzimidazoles
RNA Replicase/antagonists & inhibitors.
J Med Chem 2006 Jul 27;49(15):4721-36
nonstructural protein 15, SARS coronovirus
EC 2.7.7.48
*RNA Replicase
*Viral Nonstructural Proteins.
J Virol 2004 Sep;78(18):9977-86
nonstructural protein 3, SARS coronovirus
EC 2.7.7.48
*RNA Replicase
*Viral Nonstructural Proteins.
J Virol 2004 Sep;78(18):9977-86
1-
(2-
cyclopropylethyl)-
3-
(1,1-
dioxo-
2H-
1,2,4-
benzothiadiazin-
3-
yl)-
6-
fluoro-
4-
hydroxy-
2(1H)-
quinolinone
0
*Thiadiazines
*Quinolones
RNA Replicase/antagonists & inhibitors.
J Med Chem 2006 Feb 9;49(3):971-83
L protein, hantavirus
EC 2.7.7.48
*RNA Replicase
*Viral Proteins.
Arch Virol 2005 Mar;150(3):533-56
(5-
cyano-
8-
methyl-
1-
propyl-
1,3,4,9-
tetrahydropyrano(3,4-
b)indol-
1-
yl)acetic acid
0
*Indoles
*Pyrans
RNA Replicase/antagonists & inhibitors.
Antimicrob Agents Chemother 2004 Dec;48(12):4813-21
SDE1 protein, Arabidopsis
EC 2.7.7.48
*RNA Replicase
*Arabidopsis Proteins.
Cell 2000 May 26;101(5):543-53
RdRP1 protein, Arabidopsis
EC 2.7.7.48
*RNA Replicase
*Arabidopsis Proteins.
Mol Plant Microbe Interact 2003 Mar;16(3):206-16
RNA-
directed RNA polymerase RRF-
3, C elegans
EC 2.7.7.48
*RNA Replicase.
Curr Biol 2002 Aug 6;12(15):1317-9
SGS2 protein, Arabidopsis
0
*Arabidopsis Proteins
RNA Replicase.
Cell 2000 May 26;101(5):533-42
EGO-
1 protein, C elegans
EC 2.7.7.-
*RNA Replicase
*Caenorhabditis elegans Proteins.
Curr Biol 2000 Feb 24;10(4):169-78
QDE1 protein, Neurospora crassa
EC 2.7.7.-
*Fungal Proteins
*RNA Replicase.
Nature 1999 May 13;399(6732):166-9
Aqr protein, mouse
EC 2.7.7.-
*RNA Replicase.
Dev Dyn 1998 Jun;212(2):304-17
NS1 protein, Flavivirus
0
*Viral Nonstructural Proteins
RNA Replicase.
J Gen Virol 1996 Jun;77(Pt 6):1287-94
NS5 protein, flavivirus
0
*Viral Nonstructural Proteins
Methyltransferases
RNA Replicase.
J Gen Virol 1995 Sep;76(Pt 9):2317-21
lambda3 protein, Reovirus
EC 2.7.7.-
*RNA Replicase
*Viral Proteins
Viral Core Proteins.
Res Virol 1994 Sep-Oct;145(5):277-85
polymerase 3Dpol, poliovirus
EC 2.7.7.-
*RNA Replicase.
J Biol Chem 1994 Nov 18;269(46):29173-81
NS-
5 protein, hepatitis C virus
0
*Viral Nonstructural Proteins
RNA Replicase.
J Gen Virol 1994 May;75( Pt 5):1053-61
tobacco mosaic virus replicase
EC 2.7.7.-
*RNA Replicase
Tobacco Mosaic Virus.
Mol Plant Microbe Interact 1993 Sep-Oct;6(5):635-42
influenza virus polymerase basic protein 1
0
*Viral Proteins
Orthomyxoviridae
RNA Replicase.
J Virol 1992 Nov;66(11):6314-21
PA protein, influenza viruses
0
*RNA Replicase
*Viral Proteins
Phosphoproteins.
Virology 1989;172(2):601
nuclear inclusion protein a, mosaic viruses
EC 3.4.-
*Endopeptidases
*Viral Proteins
RNA Replicase.
Biosci Biotechnol Biochem 1993 May;57(5):710-4; Virology 1989;170(2):362
PB2 protein, Influenzavirus A
0
*RNA Replicase
*Viral Proteins.
Bioorg Khim 1988;14(4):548
RNP transcriptase
EC 2.7.7.-
*RNA Replicase.
Virus Res 1985;3(4):353
L protein, vesicular stomatitis virus
EC 2.7.7.48
*RNA Replicase
*Viral Proteins
Vesicular stomatitis Indiana virus.
J Gen Virol 1984;65(Pt 3):663