encyclopedia of medical concepts
ψ 
ψ 
ψ 

Renin

More information in Books or onNLM PubMed
Definition: A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.  do not confuse with RENNIN see CHYMOSIN    Other names Renin, Inactive; Renin, Big; Pre Prorenin; Angiotensin Forming Enzyme; Prorenin; Preprorenin; Pre-Prorenin; Inactive Renin; Cryorenin; Big Renin; Angiotensinogenase; Angiotensin-Forming Enzyme
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
mRen2 protein, rat  0   *Renin. Hypertension. 2011 Oct;58(4):665-71
Ren2 protein, rat  0   *Renin. Hypertension 2009 Feb;53(2):158-65
5-amino-4-hydroxy-7-(4-methoxy-3-(3-methoxypropyl)benzyl)-2,8-dimethylnonanoic acid butylamide  0   *Amides *Anisoles Renin/antagonists & inhibitors. J Med Chem 2007 Oct 4;50(20):4818-31
RENBP protein, human  EC 5.1.3.8   *Carbohydrate Epimerases *Carrier Proteins Renin.
Renbp protein, rat  EC 5.1.3.8   *Carbohydrate Epimerases *Carrier Proteins Renin.
Renbp protein, mouse  EC 5.1.3.8   *Carbohydrate Epimerases *Carrier Proteins Renin.
Ren2 protein, mouse  0   *Renin. J Am Soc Nephrol 2002 Nov;13(11):2681-7
prorenin receptor  0   *Receptors, Cell Surface Protein Precursors Renin. J Clin Invest 2002 Jun;109(11):1417-27
ATP6AP2 protein, human  0   *Receptors, Cell Surface *Vacuolar Proton-Translocating ATPases Renin. J Clin Invest 2002 Jun;109(11):1417-27
aliskiren  0   *Amides *Fumarates Antihypertensive Agents Renin/antagonists & inhibitors. Hypertension 2002 Jan;39(1):E1-8AMTURNIDE; TEKTURNA HCT; TEKTURNA; VALTURNA; TEKAMLO
CGP 60536  0   *Anisoles Renin/antagonists & inhibitors. J Immunoassay 2000 Feb;21(1):65-84
N-(1-cyclohexylmethyl-2,4-dihydroxy-5-methylhexyl)-N(alpha)-methyl-N(alpha)-(N-(4-hydroxypiperidino)carbonyl-phenylalanyl)histidinamide  0   *Dipeptides *Fatty Alcohols Renin/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1997 Oct 45(10):1631-41
PD 134672  0   *Thiazoles Alanine/*analogs & derivatives Renin/antagonists & inhibitors. Can J Physiol Pharmacol 1995 Oct;73(10):1512-8
BILA 2157 BS  160937-56-4   *Pyridines *Thiazoles Renin/antagonists & inhibitors. Can J Physiol Pharmacol 1995 Oct;73(10):1512-8
EMD 58265  0   *Oligopeptides Renin/antagonists & inhibitors. Am J Hypertens 1995 Apr;8(4 Pt 1):433-6
SC 51106  0   Histidine/*analogs & derivatives Renin/antagonists & inhibitors. Bioorg Med Chem 1994 Sep;2(9):909-18
YM 26365  0   *Benzodiazepinones Renin/antagonists & inhibitors. Eur J Pharmacol 1994 Dec 27;271(2-3):341-8
4-N-(morpholinoacetyl-(1-naphthyl)-alanyl-N-methyl-(4-thiazolyl)-alanyl)amino-3-hydroxy-5-cyclohexyl-1-(4-pyridyl)-1-pentanone  0   *Dipeptides *Morpholines Renin/antagonists & inhibitors. Pharm Res 1994 Oct;11(10):1448-51
ethyl 2-benzyl-3-((1-methyl-1-((morpholin-4-yl)carbonyl)ethyl)sulfonyl)propionate  0   *Morpholines *Phenylpropionates Renin/antagonists & inhibitors. Bioorg Med Chem 1994 Jun;2(6):403-10
ethyl 2-benzyl-3-(tert-butylsulfonyl)propionate  0   *Phenylpropionates Renin/antagonists & inhibitors. Bioorg Med Chem 1994 Jun;2(6):403-10
renin inhibitory peptide, R-PEP-27  103122-78-7   *Oligopeptides Renin/antagonists & inhibitors. Am J Hypertens 1994 Apr;7(4 Pt 1):295-301
CI 992  135704-06-2   *Dipeptides Renin/antagonists & inhibitors. J Pharmacol Exp Ther 1994 Jan;268(1):372-9
ciprokiren  143631-62-3 1H-Imidazole-4-propanamide, N-(1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl)-alpha-((2-(((1,1-dimethyl-2-(4-morpholinyl)-2-oxoethyl)sulfonyl)methyl)-1-oxo-3-phenylpropyl)amino)-, (1S-(1R*(R*(R*)),2S*,3R*))  *Imidazoles Renin/antagonists & inhibitors. Life Sci 1994;54(6):87-92
U 77436  128657-36-3   *Oligopeptides Renin/antagonists & inhibitors. Pharm Res 1993 Oct;10(10):1548-51
S 2864  150739-46-1 1-Piperidinebutanamide, 4-amino-N-(2-((1-(cyclohexylmethyl)-2,3-dihydroxy-5-(2-pyridinyl)pentyl)amino)-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl)-gamma-oxo-alpha-(phenylmethyl)-, (1S-(1R*(R*(S*)),2S*,3R*))-, monoacetate (salt)  *Oligopeptides Renin/antagonists & inhibitors. J Med Chem 1993 Sep 17;36(19):2788-800
FK 906  150679-23-5 FK 906  *Morpholines Histidine/*analogs & derivatives Renin/antagonists & inhibitors. Clin Ther 1993 May-Jun;15(3):539-48
PD 135390  150351-31-8   *Dipeptides Renin/antagonists & inhibitors. Antiviral Res 1993 May;21(1):73-84
PD 134922  150351-30-7   *Dipeptides Renin/antagonists & inhibitors. Antiviral Res 1993 May;21(1):73-84
N-(2-((1-(cyclohexylmethyl)-2-(3-ethyl-2-oxo-5-oxazolidinyl)-2-hydroxyethyl)amino)-2-oxo-1-(2-thienylmethyl)ethyl)-gamma-oxo-alpha-(phenylmethyl)-4-morpholinebutanamide  122225-00-7   *Dipeptides *Oxazoles Renin/antagonists & inhibitors. J Med Chem 1993 Feb 19;36(4):449-59
5,8-diaza-10,11-dihydroxy-9-cyclohexylmethyl-13-methyl-1-(4-methylpiperazin-1-yl)-3-phenylmethyl-6-(thiazol-4-ylmethyl)tetradecane-1,4,7-trione  0   *Dipeptides *Piperazines Renin/antagonists & inhibitors. J Med Chem 1993 Feb 19;36(4):449-59
H 218-54  117760-71-1   *Cyclohexanes Valine/*analogs & derivatives Renin/antagonists & inhibitors. J Pharm Biomed Anal 1992 Oct-Dec;10(10-12):959-63
EMD 56133  126722-78-9   *Oligopeptides Renin/antagonists & inhibitors. Biochem Pharmacol 1993 Feb 24;45(4):909-16
A 74273  130316-95-9   *Amides *Morpholines Renin/antagonists & inhibitors. Clin Chem 1992 Nov;38(11):2239-43
A 62095  144499-88-7 L-Leucinamide, N-(ethoxycarbonyl)-L-leucyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-4-methylpentyl)-, (1S-(1R*,2S*,3R*))  *Dipeptides Renin/antagonists & inhibitors. Acta Crystallogr B 1992 Aug 1;48 ( Pt 4):476-88
CP 80794  119625-78-4   *Dipeptides *Morpholines Renin/antagonists & inhibitors. J CardiovascPharmacol 1992 Jul;20(1):75-82
zankiren hydrochloride  138742-43-5   *Piperazines *Thiazoles Renin/antagonists & inhibitors. Science 1992 Sep 25;257(5078):1940-3
PD 125754  124339-32-8   *Cyclohexanes *Oligopeptides Renin/antagonists & inhibitors. Biochemistry 1992 Sep 8;31(35):8142-50
PD 125967  128139-14-0   *Cyclohexanes *Oligopeptides Renin/antagonists & inhibitors. Biochemistry 1992 Sep 8;31(35):8142-50
CP 85339  119625-53-5 L-Cysteinamide, L-prolyl-L-phenylalanyl-N-(1-(cyclohexylmethyl)-2-hydroxy-3-(1-methylethoxy)-3-oxopropyl)-S-methyl-, monohydrochloride, (R-(R*,S*))  *Oligopeptides Renin/antagonists & inhibitors. Nature 1992 Jun 11;357(6378):466-72
YM 21095  0   *Dipeptides *Morpholines *Naphthalenes Renin/antagonists & inhibitors. Am J Hypertens 1991 Dec;4(12 Pt 1):932-8
CP 81282  121584-61-0 L-Norleucinamide, N-(4-morpholinylcarbonyl)-L-phenylalanyl-N-(1-(cyclohexylmethyl)-3,3-difluoro-4-(methylamino)-2,4-dioxobutyl)-, (S)  *Oligopeptides Renin/antagonists & inhibitors. Adv Exp Med Biol 1991:306:269-74
N-acetylphenylalanyl-N-(4-((butylamino)carbonyl)-1-(cyclohexylmethyl)-2-hydroxy-5-methylhexyl)norleucinamide  138571-29-6   *Dipeptides Renin/antagonists & inhibitors. J Med Chem 1992 Mar 6;35(5):833-46
4-cyclohexyl-2-hydroxy-3-((2-((2-(1-oxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl)amino)pentanoyl)amino)butyric acid isopropyl ester  139238-61-2   *Indoles Renin/antagonists & inhibitors. J Med Chem 1992 Mar 6;35(5):823-32
EMD 55068  126784-34-7   *Oligopeptides *Pyrazines Renin/antagonists & inhibitors. Biochim Biophys Acta Jan 31;1103(2):219-28
EMD 55450  126657-82-7   *Oligopeptides *Pyrazines Renin/antagonists & inhibitors. Biochim Biophys Acta 1991 Jan 31;1103(2):219-28
peptide 8A  137051-72-0   *Protein Precursors *Renin. J Hypertens 1991;9(6):483
EMD 52859  0   Renin/*antagonists & inhibitors. Proc Soc Exp Biol Med 1991;197(4):387
EMD 51921  133928-36-6 L-threo-Pentonamide, N-(1-((((4-amino-2-methyl-5-pyrimidinyl)methyl)amino)carbonyl)-2-methylbutyl)-5-cyclohexyl-2,4,5-trideoxy-4-((N-(N-((1,1-dimethylethoxy)carbonyl)-L-phenyl-2,6-t2-alanyl)glycyl)amino)-, (S-(R*,R*))  *Dipeptides *Pyrimidines Renin/antagonists & inhibitors. Proc Soc Exp Biol Med 1991;197(4):287
cyclothiazomycin  133352-26-8   *Peptides, Cyclic *Thiazoles Renin/antagonists & inhibitors. J Antibiot (Tokyo) 1991;44(6):582
PD 132002  134452-04-3   *Dipeptides *Morpholines Renin/antagonists & inhibitors. J Med Chem 1991;34(7):1935
GR 70982  124646-43-1   *Dipeptides *Pyridines Renin/antagonists & inhibitors. Eur J Pharmacol 1991;192(3):329
cyclic(3-1)-1-(carboxymethyl)prolyl-phenylalanyl-histidinamide  132235-85-9   *Peptides, Cyclic Renin/antagonists & inhibitors. J Med Chem 1991;34(4):1276
S 862033  115654-28-9   *Peptides Renin/antagonists & inhibitors. Biochim Biophys Acta 1990;1027(1):25
S 863390  130024-92-9   *Peptides Renin/antagonists & inhibitors. Biochim Biophys Acta 1990;1027(1):25
remikiren  135669-48-6   *Imidazoles Renin/antagonists & inhibitors.
Pharma Action Antihypertensive Agents ; Protease Inhibitors 		BMJ 1990;301(6745):205
SDZ 213-776  130507-23-2   *Oligopeptides Renin/antagonists & inhibitors. Biochem Pharmacol 1990;40(4):765
A 65317  122224-84-4   *Oxazolidinones Histidine/*analogs & derivatives Renin/antagonists & inhibitors. Am J Physiol 1990;259(1 Pt 2):R7
EMD 52297  129049-51-0   *Oligopeptides Renin/antagonists & inhibitors. Am J Physiol 1990;258(6 Pt 2):H1625
ES 8891  129445-88-1   *Dipeptides *Morpholines Renin/antagonists & inhibitors. Hypertension 1990;15(6 Pt 2):909
CGP 44099  128856-81-5   *Oligopeptides Renin/antagonists & inhibitors. J Pharmacol Exp Ther 1990;253(2):513
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy