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Phenobarbital

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Definition: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory GAMMA-AMINOBUTYRIC ACID subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.     
Pharmacological Action Anticonvulsants; Excitatory Amino Acid Antagonists; GABA Modulators; Hypnotics and Sedatives
Examples Primidone 		Other names Phenylbarbital; Phenobarbitone; Phenemal; Sodium, Phenobarbital; Monosodium Salt Phenobarbital; Acid, Phenylethylbarbituric; Phenylethylbarbituric Acid; Phenobarbital, Monosodium Salt; Phenobarbital Sodium; Luminal; Hysteps; Gardenal
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,4-dithiophenobarbital  0   Phenobarbital/*analogs & derivatives. Acta Pol Pharm. 2009 Mar-Apr;66(2):123-8
vegetamin  0   *Chlorpromazine *Phenobarbital Drug Combinations. Leg Med (Tokyo) 2006 May;8(3):172-6
2-thiophenobarbital  0   Phenobarbital/*analogs & derivatives. Acta Pol Pharm. 2005 Sep-Oct;62(5):335-40
N,S-dimethyl-2-thiophenobarbital  0   Phenobarbital/*analogs & derivatives. Acta Pol Pharm 2003 Jul-Aug;60(4):253-6
N,N-dimethyl-2-thiophenobarbital  0   Phenobarbital/*analogs & derivatives. Acta Pol Pharm 2003 Jul-Aug;60(4):253-6
N-methyl-2-thiophenobarbital  0   Phenobarbital/*analogs & derivatives. Acta Pol Pharm 2003 Jul-Aug;60(4):247-52
S-methyl-2-thiophenobarbital  0   Phenobarbital/*analogs & derivatives. Acta Pol Pharm 2003 Jul-Aug;60(4):247-52
N-3-benzylphenobarbital  0   Phenobarbital/*analogs & derivatives. Drug Metab Dispos 2002 Mar;30(3):235-9
valcophen  0   *Aspirin *Caffeine *Phenobarbital Drug Combinations. Fiziol Zh 1998;44(5-6):102-5
4-azidophenobarbital  0   *Azides Phenobarbital/*analogs & derivatives. Drug Metab Dispos 1997 Dec;25(12):1442-6
Donnatal  0   *Atropine *Phenobarbital *Scopolamine Hydrobromide Drug Combinations. Clin Pediatr (Phila) 1991;30(5):281
Hydanphene  64217-16-9   *Phenobarbital *Phenytoin Drug Combinations. Neurologija 1987;36(1-4):85
1-diethylaminoethylphenobarbital  1164-33-6   Phenobarbital/*analogs & derivatives. Arch Pharm (Weinheim) 1987;320(11):1103
Falepsin  56343-96-5   *Phenobarbital *Phenylpropanolamine Drug Combinations. Kardiologiia 1987;27(5):48
1-methyl-5-pentyl-5-phenylbarbituric acid  112769-18-3   Phenobarbital/*analogs & derivatives. Arch Pharm (Weinheim) 1987;320(4):323
perphyllon  8066-99-7   *Atropine Derivatives *Papaverine *Phenobarbital *Theophylline Drug Combinations. Wien Med Wochenschr 1986;136(9):213
belladonna alkaloid, ergotamine, phenobarbital drug combination  0   *Belladonna Alkaloids *Ergotamines *Phenobarbital Drug Combinations. Iowa Med 1984;74(12):536
5,5-diphenylbarbituric acid  21914-07-8   Phenobarbital/*analogs & derivatives. J Pharmacol Exp Ther 1985;232(1):127
phenobarbital-N-glucoside  72209-10-0   Phenobarbital/*analogs & derivatives. Biomed Mass Spectrom 1984;11(9):462
1-(2,3,4,6-tetraacetyl-beta-D-glucopyranosyl)phenobarbital  72209-11-1 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)-, (Z)  Phenobarbital/*analogs & derivatives. Drug Metab Dispos 1984;12(6):792
aspirin, codeine, phenacetin, phenobarbital drug combination  52453-04-0   *Aspirin *Codeine *Phenacetin *Phenobarbital Drug Combinations. Eksp Med Morfol 1983;22(1):39
SR 82 tablets  85099-49-6 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-, mixt. with 4,5-dihydro-2-(phenylmethyl)-1H-imidazole and N-methyl-N-(2-phenylethyl)benzeneethanamine  *Phenethylamines *Phenobarbital *Tolazoline Drug Combinations. Pharmazie 1982;37(10):737
1-methyl-5-phenyl-5-butylbarbituric acid  64153-56-6   Phenobarbital/*analogs & derivatives. Arzneimittelforsch 1982;32(10):1281
aminophylline, cycloclenbutrerol, diphenydramine, phenobarbital drug combination  0   *Aminophylline *Diphenhydramine *Phenobarbital Clenbuterol/*analogs & derivatives Drug Combinations Asthma/drug therapy. Chung Hua Chieh Ho Ho Hu Hsi Hsi Chi Ping Tsa Chih 1982;4(6):333
phenobarbital quinidine  1400-48-2   *Phenobarbital *Quinidine Drug Combinations. Med Clin (Barc) 1981;77(10):431
Kominek's mixture  81424-60-4 Benzoic acid, 2-(acetyloxy)-, mixt. with 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine, 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione, 2-methyl-2-propyl-1,3-propanediyl dicarbamate and N,N,alpha-trimethyl-10H-phenothiazone-10-ethanamine mono  *Aspirin *Chlorpromazine *Meprobamate *Phenobarbital *Promethazine Drug Combinations. Stomalologiia (Mosk) 1981;60(6):24
Pencardin  80186-95-4 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-, mixt. with 2,2-bis(hydroxymethyl)-1,3-propanediol, 1-((3,4-diethoxyphenyl)methylene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride and 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compd. wi  *Aminophylline *Phenobarbital *Propylene Glycols Drug Combinations Papaverine/*analogs & derivatives. Pneumonol Pol 1981;49(1):43
Migraine-Kranit  77193-78-3 Acetamide, N-(4-hydroxyphenyl)-, mixt. with 1-((3,4-diethoxyphenyl)methyl)-6,7-diethoxyisoquinoline hydrochloride, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one, 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione and 5-ethyl-5-phenyl  *Acetaminophen *Caffeine *Phenobarbital Antipyrine/*analogs & derivatives Drug Combinations Papaverine/*analogs & derivatives. Arzneim Forsch 1981;31(1):105
Myocardon  0   *Aminophylline *Atropine *Nitroglycerin *Papaverine *Phenobarbital Drug Combinations. ZFA (Stuttgart) 1980;56(7):511
dimethylphenobarbital  730-66-5   Phenobarbital/*analogs & derivatives. Drug Metab Dispos 1980;8(4):208
5-phenyl-5-(4-aminobutyl)barbituric acid  79181-97-8   Phenobarbital/*analogs & derivatives. Res Commun Chem Pathol Pharmacol 1980;28(2):309
3-hydroxyphenobarbital  427-17-8 2,4,6(1H,3H,5H)-pyrimidinetrione, 5-ethyl-5-(3-hydroxyphenyl)  Phenobarbital/*analogs & derivatives. Biochem Pharmacol 1980;29(8):1127
mephobarbital, phenobarbital, phenytoin drug combination  0   *Mephobarbital *Phenobarbital *Phenytoin Drug Combinations. Folia Psychiatr Neurol Jpn 33(3):319;1979
fenalgin  77257-34-2 Benzoic acid, 2-(acetyloxy)-, mixt. with 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione, (S-(R*,S*))-3-(dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)propyl propanoate 2-naphthalenesulfonate, 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione and N-(4  *Caffeine *Acetaminophen *Phenobarbital *Dextropropoxyphene Drug Combinations. Bratisl Lek Listy 71(4):421;1979
didepil  37335-54-9 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-, mixt. with (+-)-alpha-cyclohexyl-alpha-phenyl-1-pyrrolidinepropanol  *Phenobarbital *Procyclidine Drug Combinations. Neurol Neurochir Pol 12(4):421;1978
Quadrinal  78515-92-1 Benzoic acid, 2-hydroxy-, calcium salt (2:1), compd. with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:1), mixt. with 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione, (R-(R*,S*))-alpha-(1-(methylamino)ethyl)benzenemethanol hydrochloride and potassiu  *Ephedrine *Iodides *Phenobarbital *Salicylates *Theophylline Drug Combinations. South Dakota J Med 31(10):16;1978
4-hydroxyphenobarbital  379-34-0 5-ethyl-5-(4-hydroxyphenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione  Phenobarbital/*analogs & derivatives. Clin Chem 23(5):873;1977; Clin Pharmacol Anti-Epileptic Drugs W3 WO925:131;1974c; J Chromatogr 154(2):349;1978; The induction of drug metabolism W3 SY1055 14:253;1978
exrheudon-dragees  77306-13-9 Methanesulfonic acid, ((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino)-, sodium salt, mixt. with 4-butyl-1,2-diphenyl-3,5-pyrazolidinedione and 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione  *Dipyrone *Phenobarbital *Phenylbutazone Drug Combinations. Munch Med Wschr 119(3):93;1977
bellodona alkaloid, ergotamine, phenolbarbital drug combination  77190-10-4 Bellataminal  *Belladonna Alkaloids *Ergotamines *Phenobarbital Drug Combinations. Zh Nevropatol Psikhiatr 77(4):527;1977
N-methoxymethylphenobarbital  42013-65-0   Phenobarbital/*analogs & derivatives. Anal Chim Acta 88(2):261;1977
pulsnorma  78571-97-8 Ajmalan-17,21-diol, (17R,21alpha)-, mixt. with 4,5-dihydro-N-phenyl-N-(phenylmethyl)-1H-imidazole-2-methanamine monohydrochloride, 5-ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione and (7S-(7alpha,7aalpha,14alpha,14abeta))-dodecahydro-7,14-meth  *Ajmaline *Antazoline *Phenobarbital *Sparteine Drug Combinations. Klin Med (Mosk) 53(7):57;1975
barbexaclone  4388-82-3   Phenobarbital/*analogs & derivatives. Arq Neuropsiquiatr 35(1):68;1977; Arq Neuropsiquiatr 35(3):277;1977; Arq Neuropsiquiatr 36(2):135;1978; Arq Neuropsiquiatr 36(3):245;1978; Arq Neuropsiquiatr 36(4):340;1978; Cesk Psychiatr 71(2-3):108;1975; Eur Neurol 10(3):179;1973
brondiletten retard  77124-30-2 Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride, mixt. with 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione, 1-hexyl-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione and N,N,4-trimethyl-gamma-phenylbenzenepropana  *Benactyzine *Phenobarbital *Propylamines Drug Combinations Theobromine/*analogs & derivatives Delayed-Action Preparations. Med Monatsschr 29(11):513;1975; Med Welt 26(38):1733;1975; Ther Ggw 115(12):2104;1976
eterobarb  27511-99-5 N,N'-dimethoxymethylphenobarbital  Phenobarbital/*analogs & derivatives. Ann Neurol 5(2):121;1979; Neurology 25(5):399;1975; Proc West Pharmacol Soc 20:73;1977; Trans Am Neurol Assoc 101:204;1976
Tedral  8057-98-5   *Ephedrine *Phenobarbital *Theophylline Drug Combinations. Ann Allergy 1979;43(6):348; Therapeutique 49(9):591;1974
1-methyl-5-phenyl-5-propylbarbituric acid  36045-93-9 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-phenyl-5-propyl  Phenobarbital/*analogs & derivatives. Naunyn Schmiedebergs Arch Pharmacol 282(4):367;1974
tetrabamate  60763-47-5 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-bis(2-((aminocarbonyl)oxy)-3-butoxypropyl)-5-ethyl-5-phenyl-, mixt. with 1-(2-((aminocarbonyl)oxy)-3-butoxypropyl)-5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione and 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrio  *Phenobarbital Drug Combinations. Arzneim Forsch 1979;29(9):1398; Med Exp Hyg 33(1164):1441;1975; Praxis 65(14):420;1976; Rev Med 91(1):57;1971; Schweiz Med Wchnschr 1978;108(17):540; Therapeutique 49(7):463;1973
franol  8058-86-4   *Ephedrine *Ethylenediamines *Phenobarbital *Theophylline Drug Combinations Asthma/drug therapy.
dichlorophenobarbital  23256-01-1 5-(3,4-dichlorophenyl)-5-ethylbarbituric acid  Phenobarbital/*analogs & derivatives.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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