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Jumonji Domain-Containing Histone Demethylases

More information in Books or onNLM PubMed
Definition: A family of histone demethylases that share a conserved Jumonji C domain. The enzymes function via an iron-dependent dioxygenase mechanism that couples the conversion of 2-oxoglutarate to succinate to the hydroxylation of N-methyl groups.     
Examples Retinoblastoma-Binding Protein 2 		Other names Jumonji Domain Containing Histone Demethylases; JmjC Domain Containing Histone Demethylases; JmjC Domain-Containing Histone Demethylases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Jmjd5 protein, mouse  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. Development. 2012 Feb;139(4):749-59.
KDM4D protein, mouse  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. Biol Reprod 2011 Jun;84(6):1225-34
JMJD1c protein, mouse  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. Int J Oncol 2007 Jul;31(1):219-23
KDM7A protein, C elegans  EC 1.14.11.-   *Caenorhabditis elegans Proteins *Jumonji Domain-Containing Histone Demethylases. Cell Res. 2010 Aug;20(8):886-98
methyl 3-((9-(dimethylamino)nonanoyl)(methoxy)amino)propanoate  0   *Hydroxamic Acids beta-Alanine/*analogs & derivatives Jumonji Domain-Containing Histone Demethylases/antagonists & inhibitors. J Med Chem 2010 Aug 12;53(15):5629-38
methyl 3-((9-(dimethylamino)nonanoyl)(hydroxy)amino)propanoate  0   *Hydroxamic Acids beta-Alanine/*analogs & derivatives Jumonji Domain-Containing Histone Demethylases/antagonists & inhibitors. J Med Chem 2010 Aug 12;53(15):5629-38
JMJD2E protein, human  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. Chembiochem 2010 Mar 1;11(4):506-10
JMJ14 protein, Arabidopsis  EC 1.14.11.-   *Arabidopsis Proteins *Jumonji Domain-Containing Histone Demethylases. Genes Dev 2010 May 15;24(10):986-91
KDM7A protein, human  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. Cell Res 2010 Feb;20(2):154-65
KDM7 protein, mouse  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. Genes Dev. 2010 Mar 1;24(5); 432-7
KDM7 protein, zebrafish  EC 1.14.11.-   *Zebrafish Proteins *Jumonji Domain-Containing Histone Demethylases. Genes Dev. 2010 Mar 1;24(5); 432-7
FBXL11 protein, mouse  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. Proc Natl Acad Sci U S A 2010 Jan 5;107(1):46-51
Kdm6b.1 protein, zebrafish  EC 1.14.11.-   *Zebrafish Proteins *Jumonji Domain-Containing Histone Demethylases. Proc Natl Acad Sci U S A 2009 Nov 24;106(47):19889-94
KDM3A protein, human  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases Zinc Fingers. Biochem Biophys Res Commun 2008 Aug 8;372(4):892-7
Kdm2b protein, mouse  EC 1.14.11.27   *F-Box Proteins *Jumonji Domain-Containing Histone Demethylases. Mol Cell Proteomics 2007 May;6(5):820-34
KDM6B protein, human  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. Nature 2007 Oct 11;449(7163):689-94
Kdm6b protein, mouse  EC 1.5.-   *Jumonji Domain-Containing Histone Demethylases. Cell 2007 Sep 21;130(6):1083-94
KDM4B protein, human  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. J Biol Chem 2005 Aug 5;280(31):28507-18
Jhd1 protein, S cerevisiae  EC 1.14.11.-   *Saccharomyces cerevisiae Proteins *Jumonji Domain-Containing Histone Demethylases. J Biol Chem 2007 May 11;282(19):14262-71
KDM4D protein, human  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. Biochem Biophys Res Commun 2007 Aug 3;359(3):742-6
JMJD1C protein, human  EC 1.14.11.-   *Oxidoreductases, N-Demethylating *Jumonji Domain-Containing Histone Demethylases. Arch Biochem Biophys 2007 Apr 1;460(1):56-66
JHD2 protein, S cerevisiae  EC 1.14.11.-   *Saccharomyces cerevisiae Proteins *Jumonji Domain-Containing Histone Demethylases. Nat Struct Mol Biol 2007 Mar;14(3):243-5
Kdm4b protein, mouse  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases Zinc Fingers. Genes Dev 2006 Jun 15;20(12):1557-62
Kdm3a protein, mouse  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. Cell 2006 May 5;125(3):483-95
JMJD6 protein, human  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases.
KDM4A protein, human  EC 1.5.-   *Jumonji Domain-Containing Histone Demethylases. Int J Oncol 2004 Jun;24(6):1623-8
Kdm5b protein, mouse  EC 1.14.11.-   *DNA-Binding Proteins *Jumonji Domain-Containing Histone Demethylases Nuclear Proteins.
KDM3B protein, human  EC 1.14.11.-   *Jumonji Domain-Containing Histone Demethylases. Oncogene 2001 Oct 18;20(47):6946-54
KDM4C protein, human  0   *Jumonji Domain-Containing Histone Demethylases. Cancer Res. 2000 Sep 1;60(17):4735-9
KDM5B protein, human  EC 1.14.11.-   *Nuclear Proteins *Repressor Proteins *Jumonji Domain-Containing Histone Demethylases. J Biol Chem 1999 May 28;274(22):15633-45

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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