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Calmodulin

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Definition: A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.  a calcium-binding protein; /biosyn /physiol permitted    Other names Calcium-Dependent Regulator; Calcium-Dependent Activator Protein; Regulator, Calcium Dependent; Protein, Phosphodiesterase Activator; Protein, Calcium-Dependent Activator; Protein, Bovine Activator; Protein Activator, Phosphodiesterase; Factor, Phosphodiesterase Activating; Cyclic AMP Phosphodiesterase Activator; Calcium Dependent Regulator; Calcium Dependent Activator Protein; Activator, Phosphodiesterase Protein; Activator, Cyclic AMP-Phosphodiesterase; Activator Protein, Phosphodiesterase; Activator Protein, Calcium-Dependent; Activator Protein, Bovine; Activating Factor, Phosphodiesterase; AMP-Phosphodiesterase Activator, Cyclic; Regulator, Calcium-Dependent; Phosphodiesterase Protein Activator
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
hCaM L39C-mBBr-V91C-mBBr  0   *Calmodulin *Xanthones. J Med Chem 2011 Jun 9;54(11):3875-84
calmodulin (1-80)  0   *Calmodulin *Peptide Fragments. Proteins 2010 Aug 1;78(10):2265-82
calmodulin (76-148)  0   *Calmodulin *Peptide Fragments. Proteins 2010 Aug 1;78(10):2265-82
calmodulin (76-121)  0   *Calmodulin *Peptide Fragments. Brain Pathol 2010 Jan;20(1):176-89
CaBP22 protein, Arabidopsis  0   *Calmodulin *Arabidopsis Proteins. Plant Physiol 2009 May;150(1):424-36
CaM3 protein, Arabidopsis  0   *Calmodulin *Arabidopsis Proteins. Plant Physiol 2009 Apr;149(4):1773-84
14-methoxytajixanthone  0   *Xanthones Calmodulin/antagonists & inhibitors. Bioorg Med Chem 2009 Mar 15;17(6):2167-74
15-chlorotajixanthone  0   *Xanthones Calmodulin/antagonists & inhibitors. Bioorg Med Chem 2009 Mar 15;17(6):2167-74
3-(2-(4-(3-chloro-2-methylphenyl)-1-piperazinyl)ethyl)-5,6-dimethoxyindazole  0   *Indazoles *Piperazines Calmodulin/antagonists & inhibitors. Mol Pharmacol 2009 Jan;75(1):101-12
CML39 protein, Arabidopsis  0   *Calmodulin *Arabidopsis Proteins. Plant Mol Biol 2007 Aug;64(6):683-97
CML38 protein, Arabidopsis  0   *Calmodulin *Arabidopsis Proteins. Plant Mol Biol 2007 Aug;64(6):683-97
CML37 protein, Arabidopsis  0   *Calmodulin *Arabidopsis Proteins. Plant Mol Biol 2007 Aug;64(6):683-97
Cam2 protein, S pombe  0   *Calmodulin *Schizosaccharomyces pombe Proteins. Cell Struct Funct. 2006;31(2) (dup#3):181-95
CMD1 protein, S cerevisiae  0   *Calmodulin *Saccharomyces cerevisiae Proteins. Mol Biol Cell 2005 Jul;16(7):3341-52
CALM2 protein, human  0   *Calmodulin. FEBS Lett 2004 Jul 2;569(1-3):70-4
CaM9 protein, Arabidopsis  0   *Calmodulin *Arabidopsis Proteins. Planta 2002 Jan;214(3):446-55
CaM8 protein, Arabidopsis  0   *Calmodulin *Arabidopsis Proteins. Planta 2002 Jan;214(3):446-55
CaM7 protein, Arabidopsis  0   *Calmodulin *Arabidopsis Proteins. Planta 2002 Jan;214(3):446-55
potato calmodulin-binding protein, Solanum tuberosum  0   *Calmodulin *Plant Proteins. J Biol Chem 2002 Feb 8;277(6):4206-14
CALN1 protein, human  0   *Calmodulin. Mol Genet Metab 2001 Apr;72(4):343-50
CalB protein, Dictyostelium  0   *Calcium-Binding Proteins *Protozoan Proteins Calmodulin. FEBS Lett 2000 May 19;473(3):323-7
AR-2 compound  0   *Piperidines Calmodulin/antagonists & inhibitors Drug Resistance. Invest New Drugs 1999;17(2):105-10
5-((4,6-dichlorotriazin-2-yl)-amino)fluorescein-calmodulin  0   *Calmodulin *Fluoresceins. Pflugers Arch 2000 Jan;439(3):394-400
2-chloro-(6-(4-N,N-diethylaminophenyl)-1,4,5-triazin-4-yl)calmodulin  0   *Calmodulin *Triazines. Pflugers Arch 2000 Jan;439(3):394-400
CBP4 protein, Nicotiana tabacum  0   *Calmodulin-Binding Proteins *Plant Proteins Calmodulin. Plant J 1999 Oct;20(2):171-82
3-(2-(4-(3-chloro-2-methylphenyl)1-piperazinyl)ethyl)5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazol dihydrochloride 3.5 hydrate  0   *Indazoles Calmodulin/antagonists & inhibitors. Eur J Pharmacol 1997 Oct;336(1):99-106
stellettamide A  129744-24-7   *Indolizines Calmodulin/antagonists & inhibitors. Br J Pharmacol 1997 Aug;121(7):1309-14
AR-1 (Ca channel blocker)  0   *Piperidines Calmodulin/antagonists & inhibitors. Biull Eksp Biol Med 1996 Jul;122(7):40-2
HMN 709  0   *Benzylamines *Sulfonamides Calmodulin/antagonists & inhibitors. Jpn J Pharmacol 1996 Oct;72(2):127-35
2-(N-(2-aminoethyl)-N-(2,4,5-trichlorobenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine  176181-81-0   *Benzenesulfonates *Benzylamines Calmodulin/antagonists & inhibitors. Eur J Pharmacol 1996 Mar 28;299(1-3):119-26
calmodulin, 2-chloro-(epsilon-amino-lysine(75))-(6-(4-(N,N-diethylamino)phenyl)-1,3,5-triazin-4-yl)  0   *Calmodulin. Biochemistry 1994 Nov 1;33(43):12807-20
And protein, Drosophila  0   *Calcium-Binding Proteins *Drosophila Proteins Calmodulin. Biochem Genet 1994 Apr;32(3-4):119-35; Mech Dev. 2000 Jun;94(1-2):171-81.; Protein Sci. 1999 Nov;8(11):2444-54.
CALML3 protein, human  0   *Calmodulin. Exp Cell Res 1993 Sep;208(1):175-88
des(Glu(84))-calmodulin  0   *Calmodulin. Proc Natl Acad Sci U S A 1993 Jul 15;90(14):6869-73
calmodulin-diazopyruvamide  0   *Calmodulin *Pyruvates. J Biol Chem 1992 Mar 25;267(9):5847-54
MeAP29 protein, rat  0   *Proteins Calmodulin Methylation. Biochem Biophys Res Commun 1988;156(1):368
calmodulin (1-77)  0   *Calmodulin *Peptide Fragments. Methods Enzymol 1988;159(2):573
calcium-binding protein, Tetrahymena  118550-05-3   *Calmodulin *Protozoan Proteins Tetrahymena. Eur J Biochem 1988;174(4):579
calmodulin (20-31)  87548-66-1   *Calmodulin *Peptide Fragments. Bipolymers 1988;27(5):789
calmodulin (8-13)  109612-89-7   *Calmodulin *Peptide Fragments. Biochemistry 1987;26(19):6070
calmodulin-chlorpromazine complex  0   *Calmodulin Chlorpromazine/*analogs & derivatives Calcium-Transporting ATPases/antagonists & inhibitors. J Pharmacol Exp Ther 1987;243(1):171
prenylamine lactate  69-43-2   *Lactates *Prenylamine Calmodulin/antagonists & inhibitors. Endocrinol Jpn 1987;34(1):89
CGS 9343B  109826-26-8   *Benzimidazoles Calmodulin/antagonists & inhibitors.
Pharma Action Antidiarrheals 		Mol Pharmacol 1987;31(5):535
calmodulin (78-148)  131588-12-0   *Calmodulin *Peptide Fragments. Biochemistry 1985;24(16):4264
phenothiazine-calmodulin complex  0   *Calmodulin *Phenothiazines. Biochim Biophys Acta 1985;845(3):533
calmodulin, aminotyrosine(138)  0   *Calmodulin. Biopolymers 1985;24(3):547
calmodulin, aminotyrosine(99)  0   *Calmodulin. Biopolymers 1985;24(3):547
S-cyanocalmodulin  0   *Calmodulin. J Biochem (Tokyo) 1984;95(2):443
norchlorpromazine-calmodulin complex  0   *Calmodulin Chlorpromazine/*analogs & derivatives. FEBS Lett 1984;165(2):269
N-dansylaziridine-calmodulin  0   *Calmodulin. Methods Enzymol 1983;102:148
azidoiodocalmodulin  0   *Azides *Calmodulin. Biochemistry 1983;22(11):2757
3-(2-pyridyldithio)propionylcalmodulin  0   *Calmodulin. Biochemistry 1983;22(4):826
calmodulin carboxymethyl ester  0   *Calmodulin. FEBS Lett 1982;147(1):125
5-dimethylaminonaphthalene-1-sulfonyl-calmodulin  0   *Calmodulin. J Biol Chem 1982;257(18):10638
des(Ala-Lys)-calmodulin  80801-19-0 1-146-Calmodulin  *Calmodulin. Biochem Biophys Res Commun 1981;102(1):279
azidocalmodulin  0   *Azides *Calmodulin. Proc Natl Acad Sci USA 1981;78(5):2782

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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