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Drug Resistance

More information in Books or onNLM PubMed
Definition: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.  general or unspecified; prefer specifics; differentiate from DRUG TOLERANCE; resistance of parasites including protozoa goes here   
See Also Pharmacogenetics
Examples Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Herbicide Resistance; Insecticide Resistance; Insulin Resistance 		Other names Resistance, Drug
 
SubstanceCAS Registry & nameCategoriesSource
pentamidine resistance protein 1, Leishmania major  0   *Protozoan Proteins *ATP-Binding Cassette Transporters Drug Resistance. Mol Biochem Parasitol 2003 Aug 31;130(2);83-90
AR-2 compound  0   *Piperidines Calmodulin/antagonists & inhibitors Drug Resistance. Invest New Drugs 1999;17(2):105-10
CSAG2 protein, human  0   *Neoplasm Proteins Drug Resistance Taxoids. Gene 1999 Mar 18;229(1-2):75-81
CG2 protein, Plasmodium falciparum  0   *Protozoan Proteins Drug Resistance. Cell 1997 Nov 28;91(5):593-603
Zam protein, Synechocystis sp.  0   *Bacterial Proteins Drug Resistance. Plant Mol Biol 1995 Feb;27(4):779-88
Pur8 protein, Streptomyces lipmanii  0   *Membrane Transport Proteins Drug Resistance. Eur J Biochem 1993 Dec 15;218(3):963-71
bls protein, Streptoverticillium  EC 2.3.1.-   *Acetyltransferases *Bacterial Proteins Drug Resistance. Gene 1990;86(1):129
AHC 52  119666-09-0 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-, methyl 2-(methyl(phenylmethyl)amino)ethyl ester  *Dihydropyridines *Pyrazoles Drug Resistance. Cancer Res 1989;49(7):1722
tetracycline resistance-encoding transposon repressor protein  0   *Repressor Proteins DNA Transposable Elements Drug Resistance R Factors Tetracycline. J Biol Chem 1982;257(11):6605

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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