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Quinazolinones

More information in Books or onNLM PubMed
Definition: Chemicals with two conjoined aromatic rings incorporating two nitrogen atoms and one of the carbons oxidized with a keto oxygen.     
Examples Ketanserin; Methaqualone; Metolazone 		Other names Quinazolinediones
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-methoxyl-2-(3-(4-methylpiperazin-1-yl)propoxy)-10-bromo-8H-quinazolino(4, 3-b) quinazolin -8'one  0   *Quinazolinones Alkaloids. Med Chem. 2011 Jul 1;7(4):295-300
MC 2141  0   *Quinazolinones. Bioorg Med Chem 2011 Jun 15;19(12):3659-68
2-(naphthalene-1-yl)-6-pyrrolidinyl-4-quinazolinone  0   *Pyrrolidines *Quinazolinones. J Pharmacol Exp Ther 2011 Sep;338(3):942-51
2-(4'-(methylamino)phenyl)quinazolin-4(3H)-one  0   *Quinazolinones Luciferases, Firefly/antagonists & inhibitors. J Nat Prod. 2011 Jun 24;74(6):1500-2
penipanoid C  0   *Quinazolinones. J Nat Prod. 2011 May 27;74(5):1331-4
penipanoid B  0   *Quinazolinones. J Nat Prod. 2011 May 27;74(5):1331-4
NCGC 00229600  0   *Pyridines *Quinazolinones Receptors, Thyrotropin. J Clin Endocrinol Metab 2011 Feb;96(2):548-54
4-ethyl-4,6,7,8-tetrahydro-1H,3H-quinazolin-2,5-dione  0   *Quinazolinones. Chem Pharm Bull (Tokyo). 2010;58(10):1320-3
4-propyl-4,6,7,8-tetrahydro-1H,3H-quinazolin-2,5-dione  0   *Quinazolinones. Chem Pharm Bull (Tokyo). 2010;58(10):1320-3
4-(benzo(1,3)dioxol-5-yl)-2-thioxo-2,3,4,6,7,8-hexahydro-1H-quinazolin- 5-one  0   *Quinazolinones. Chem Pharm Bull (Tokyo). 2010;58(10):1320-3
CAL 101  0   *Purines *Quinazolinones Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Blood 2010 Sep 2;116(9):1460-8
SP-8203  0   *Quinazolinones. Biopharm Drug Dispos. 2010 Jul;31(5-6):358-61
3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-one  0   *Quinazolinones Thermolysin/antagonists & inhibitors. Bioorg Med Chem 2010 Jun 15;18(12):4317-27
3-phenyl-2-(trifluoromethyl)quinazolin-4(3H)-one  0   *Quinazolinones Thermolysin/antagonists & inhibitors. Bioorg Med Chem 2010 Jun 15;18(12):4317-27
2-thiophen-5-yl-3H-quinazolin-4-one  0   *Thiophenes *Quinazolinones. Bioorg Med Chem. 2010 Apr 1;18(7):2796-808
circumdatin J  0   *Benzodiazepinones *Quinazolinones. J Org Chem 2008 Jun 6;73(11):4245-7
circumdatin E  0   *Benzodiazepinones *Quinazolinones. J Org Chem 2008 Jun 6;73(11):4245-7
elinogrel  0   *Sulfonamides *Quinazolinones. J Thromb Haemost 2010 Jan;8(1):43-53
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone  0   *Quinazolinones. J Biol Chem 2010 Apr; 9;285(15):11740-52
demethoxycircumdatin H  0   *Quinazolinones. Org Biomol Chem 2010 Jan 21;8(2):419-27
demethylbenzomalvin A  0   *Quinazolinones. Org Biomol Chem 2010 Jan 21;8(2):419-27
3-(2-(2-phenyl-4-(4-pyridin-4-ylbenzyl)morpholin-2-yl)ethyl)quinazoline-2,4(1H,3H)-dione  0   *Morpholines *Quinazolinones Receptors, CCR4/antagonists & inhibitors. Eur J Pharmacol 2009 Dec 10;624(1-3):38-44
2-benzyl-3-(4-methylpiperazin-1-yl)quinoxaline  0   *Piperazines *Quinazolinones. J Med Chem 2008 Apr 24;51(8):2457-67
6,7-dichloro 3-(4-methylpiperazin-1-yl)quinoxalin-2(1H)-one  0   *Piperazines *Quinazolinones. J Med Chem 2008 Apr 24;51(8):2457-67
proquinazid  0   *Quinazolinones. Pest Manag Sci 2009 Aug;65(8):878-84
3-(furan-2-ylmethyl)-2-(4-methoxy-3-(phenoxymethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one  0   *Quinazolinones Receptors, Thyrotropin/agonists. Proc Natl Acad Sci U S A 2009 Jul 28;106(30):12471-6
N-(4-(5-(3-benzyl-5-hydroxy-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxybenzyloxy)phenyl)acetamide  0   *Acetamides *Quinazolinones Receptors, Thyrotropin/agonists. Proc Natl Acad Sci U S A 2009 Jul 28;106(30):12471-6
N-(4-(5-(3-(furan-2-ylmethyl)-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxybenzyloxy)phenyl)acetamide  0   *Acetamides *Quinazolinones Receptors, Thyrotropin/agonists. Proc Natl Acad Sci U S A 2009 Jul 28;106(30):12471-6
2-vinylquinazolin-4-(3H)-one  0   *Vinyl Compounds *Quinazolinones. Mol Oncol 2008 Jun;2(1):70-80
2-(5'-chloro-2'-hydroxyphenyl)-6-chloro-4-(3H)-quinazolinone  0   *Quinazolinones. Cytometry A 2009 Feb;75(2):163-8
2-mercapto-4(3H)-quinazolinone  0   *Quinazolinones. Arch Biochem Biophys 2008 Nov 1;479(1):28-38
wuchuyuamide IV  0   *Quinazolinones Alkaloids. Fitoterapia. 2008 Jun;79(4):317-8
4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide  0   *Indazoles *Quinazolinones Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors. J Med Chem 2008 Aug 28;51(16):4858-61
3-amino-5,6,7,8-tetrahydro-2-(4-(4-(quinolin-2-yl)piperazin-1-yl)butyl)quinazolin-4-(3H)-one  0   *Quinolines *Quinazolinones Receptor, Serotonin, 5-HT1A/agonists Receptors, Serotonin, 5-HT3/agonists. J Pharmacol Exp Ther 2007 Sep;322(3):1315-23
PF 00299804  0   *Quinazolinones. Cancer Res 2007 Dec 15;67(24):11924-32
YIL 870  0   *Piperidines *Quinazolinones Receptors, Ghrelin/antagonists & inhibitors. Endocrinology 2007 Nov;148(11):5175-85
YIL 781  0   *Piperidines *Quinazolinones Receptors, Ghrelin/antagonists & inhibitors. Endocrinology 2007 Nov;148(11):5175-85
6-(4-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylquinazolin-4(3H)-one  0   *Quinazolinones Receptors, Ghrelin/antagonists & inhibitors. J Med Chem 2007 Oct 18;50(21):5202-16
6-(4-fluorophenyl)-2-isopropyl-3-((1-isopropylpiperidin-3-yl)methyl)quinazolin-4(3H)-one  0   *Quinazolinones Receptors, Ghrelin/antagonists & inhibitors. J Med Chem 2007 Oct 18;50(21):5202-16
2-(2'-phosphoryloxyphenyl)-6-iodo-4-(3H)-quinazolinone  0   *Phosphoric Acid Esters *Quinazolinones Iodine Radioisotopes. Bioconjug Chem 2007 May-Jun;18(3):754-64
7-(3-(1-aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione  0   *Pyrrolidines *Quinazolinones DNA Gyrase/antagonists & inhibitors DNA Topoisomerase IV/antagonists & inhibitors. Antimicrob Agents Chemother 2007 Apr;51(4):1191-201
3-amino-7-(3-(1-aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione  0   *Pyrrolidines *Quinazolinones DNA Gyrase/antagonists & inhibitors DNA Topoisomerase IV/antagonists & inhibitors. Antimicrob Agents Chemother 2007 Apr;51(4):1191-201
3-(2-(pyrrolidin-1-yl)ethoxy)-1,10b-dihydro-(1,2,4)triazolo(1,5-c)quinazolin-5(6H)-one  0   *Triazoles *Quinazolinones. Biochem Biophys Res Commun 2007 Jul 6;358(3):842-7
6-iodo-2-methyl-4(3H)-quinazolinone  0   *Quinazolinones. Lipids Health Dis 2005;4:22
6,8-dibromo-2-methyl-4(3H)-quinazolinone  0   *Quinazolinones. Lipids Health Dis 2005;4:22
mackinazolinone  0   *Quinazolinones. Org Lett 2005 Jul 21;7(15):3363-6
5,7-dihydroxy-3-(4-hydroxyphenyl)-4(3H)-quinazolinone  0   *Quinazolinones. J Med Chem 2006 Apr 20;49(8):2440-55
2-(1'-phenyl-3'-(3-chlorophenyl)-2'-propenylidene)hydrazino-3-methyl-4(3H)-quinazolinone  0   *Hydrazines *Quinazolinones. Eur J Drug Metab Pharmacokinet 2005 Oct-Dec;30(4):255-60
5-chloro-2-(3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl)-4(3H)-quinazolinone  0   *Pyridines *Quinazolinones. J Pharmacol Exp Ther. 2004 Aug;310(2):425-36
2-(3-(4-(4-chlorophenyl)-1-piperazinyl) propyl)-4(3H)-quinazolinone  0   *Piperazines *Quinazolinones. J Pharmacol Exp Ther. 2004 Jun;309(3):1067-78
3-(o-bromo)-phenyl-2-(2',3'-dihydroxypropylthio)-4(3H)-quinazolinone  0   *Quinazolinones Sulfhydryl Compounds. Pharmazie. 2003 Apr;58(4):242-4
ammonium 2-(2'-phosphoryloxyphenyl)-6-iodo-4-(3H)-quinazolinone  0   *Quaternary Ammonium Compounds *Quinazolinones. Bioconjug Chem 2002 Mar-Apr;13(2):357-64
2-(2-(5-bromo-1H-indol-3-yl)ethyl)-3-(1-methylethoxyphenyl)-4-(3H)-quinazolinone  0   *Quinazolinones Receptors, Cholecystokinin/antagonists & inhibitors. Neuroreport 2001 Aug 28;12(12):2717-20
2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone  0   *Pyrrolidines *Quinazolinones. J Med Chem 2000 Nov 16;43(23):4479-87
DPC 961  0   *Quinazolinones. Chem Res Toxicol 2000 Aug;13(8):775-84
2-(5'-chloro-2'-hydroxyphenyl)-4-(3H)-quinazolinone  0   *Quinazolinones. J Microbiol Methods 1999 Oct:38(1-2):25-31
triazolo(4,3-a)quinazolinone  0   *Triazoles *Quinazolinones Coccidiostats. Farmaco 1999 Jul 30;54(7):486-95
3-(hydroxy-4,4-dimethyl-2-oxo-3-quinolizidyl)-4-quinazolinone  0   *Quinolizines Quinazolinones. J Med Chem 1999 Aug 12;42(16):3163-6
CL 329167  0   *Tetrazoles *Quinazolinones Receptor, Angiotensin, Type 1. Clin Exp Hypertens 1997 Nov;19(8):1247-61
6-chloro-2-methyl-4(1H)-quinazolinone  7142-09-8   *Quinazolinones. J Pharm Biomed Anal 1995 Apr;13(4-5):667-70
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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