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Receptors, Thyrotropin

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Definition: Cell surface proteins that bind pituitary THYROTROPIN (also named thyroid stimulating hormone or TSH) and trigger intracellular changes of the target cells. TSH receptors are present in the nervous system and on target cells in the thyroid gland. Autoantibodies to TSH receptors are implicated in thyroid diseases such as GRAVES DISEASE and Hashimoto disease (THYROIDITIS, AUTOIMMUNE).  DF: RECEPT TSH    Other names Thyrotropin Receptors; Thyroid Stimulating Hormone Receptors; TSH Receptors; Receptors, Thyroid Stimulating Hormone; Receptors, Long Acting Thyroid Stimulator; Receptor, Thyrotropin; Receptor, TSH; Thyrotropin Receptor; Thyroid Stimulating Hormone Receptor; TSH Receptor; Receptors, TSH; Receptors, Long-Acting Thyroid Stimulator; Receptors, LATS; Receptor, LATS Immunoglobulins; LATS Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TR1402 peptide  0   Thyrotropin/*analogs & derivatives Receptors, Thyrotropin/agonists. Thyroid 2011 Jul;21(7):783-92
TR1401 peptide  0   Thyrotropin/*analogs & derivatives Receptors, Thyrotropin/agonists. Thyroid 2011 Jul;21(7):783-92
NCGC 00229600  0   *Pyridines *Quinazolinones Receptors, Thyrotropin. J Clin Endocrinol Metab 2011 Feb;96(2):548-54
3-(furan-2-ylmethyl)-2-(4-methoxy-3-(phenoxymethyl)phenyl)-2,3-dihydroquinazolin-4(1H)-one  0   *Quinazolinones Receptors, Thyrotropin/agonists. Proc Natl Acad Sci U S A 2009 Jul 28;106(30):12471-6
N-(4-(5-(3-benzyl-5-hydroxy-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxybenzyloxy)phenyl)acetamide  0   *Acetamides *Quinazolinones Receptors, Thyrotropin/agonists. Proc Natl Acad Sci U S A 2009 Jul 28;106(30):12471-6
N-(4-(5-(3-(furan-2-ylmethyl)-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxybenzyloxy)phenyl)acetamide  0   *Acetamides *Quinazolinones Receptors, Thyrotropin/agonists. Proc Natl Acad Sci U S A 2009 Jul 28;106(30):12471-6
thyrotropin-binding inhibitory immunoglobulin  0   *Immunoglobulins, Thyroid-Stimulating Receptors, Thyrotropin. Eur Neurol 1995;35(2):99-103
thyrotropin receptor (256-275)  0   *Peptide Fragments *Receptors, Thyrotropin. J Biol Chem 1994 Dec 9;269(49):30935-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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