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HIV Integrase

More information in Books or onNLM PubMed
Definition: Enzyme of the HUMAN IMMUNODEFICIENCY VIRUS that is required to integrate viral DNA into cellular DNA in the nucleus of a host cell. HIV integrase is a DNA nucleotidyltransferase encoded by the pol gene.      Other names Integration Protein, HIV; Integrase, HIV; p31 pol Gene Product, Human Immunodeficiency Virus; p31 pol Gene Product, HIV; p31 Integrase Protein, Human Immunodeficiency Viru; p31 Integrase Protein, HIV; HIV Integration Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
LEDGF peptide (361-370), human  0   *Peptide Fragments HIV Integrase. Biochem Biophys Res Commun 2010 Apr 2;394(2):260-5
N-(2-(((4-fluorobenzyl)amino)carbonyl)-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido(1,2-a)azepin-10-yl)-N,N',N'-trimethylethanediamide  0   *Azepines *Pyrimidinones HIV Integrase. J Med Chem 2008 Feb 28;51(4):861-74
9-(((dimethylamino)sulfonyl)(methyl)amino)-N-(4-fluorobenzyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimidine-2-carboxamide  0   *Aminopyridines *Pyrimidinones HIV Integrase. J Med Chem 2008 Feb 28;51(4):861-74
2-(1-(dimethylamino)-1-methylethyl)-N-(4-fluorobenzyl)-5,6-dihydroxypyrimidine-4-carboxamide  0   *Pyrimidines HIV Integrase. J Med Chem 2007 May 3;50(9):2225-39
p31 integrase protein, Human immunodeficiency virus 2  EC 2.7.7.-   *HIV Integrase.
p31 integrase protein, Human immunodeficiency virus 1  0   *HIV Integrase.
JTK 303  0   *Quinolones HIV Integrase. J Med Chem 2006 Mar 9;49(5):1506-8
aspochalasin L  0   *Cytochalasins HIV Integrase/antagonists & inhibitors. J Antibiot (Tokyo) 2005 Apr;58(4):279-83
7-(4-chlorobenzyl)-5,9-dihydroxypyrrolo(3,4-g)quinoxaline-6,8-dione  0   *Pyrroles *Quinoxalines HIV Integrase/antagonists & inhibitors. J Med Chem 2005 Mar 24;48(6):1930-40
7-(3,4-dichlorobenzyl)-5,9-dihydroxypyrrolo(3,4-g)quinoxaline-6,8-dione  0   *Pyrroles *Quinoxalines HIV Integrase/antagonists & inhibitors. J Med Chem 2005 Mar 24;48(6):1930-40
EBR28 peptide  0   *Oligopeptides HIV Integrase/antagonists & inhibitors. J Mol Biol 2002 Apr 19;318(1):45-58
HIV-1 integrase (147-175)  0   *Peptide Fragments HIV Integrase. Eur J Biochem 1999 Feb;260(1):145-55
endonuclease-integrase  EC 3.1.-   *Endodeoxyribonucleases *HIV Integrase. Mol Biol Evol 1988;5(6):645

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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