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Cyclin-Dependent Kinases

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Definition: Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.     
Examples CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 3; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase 8; Maturation-Promoting Factor 		Other names Cyclin Dependent Protein Kinases; Cyclin Dependent Kinases; Cyclin-Dependent Protein Kinases; cdk Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene  0   *Heterocyclic Compounds with 4 or More Rings Cyclin-Dependent Kinases/antagonists & inhibitors Janus Kinase 2/antagonists & inhibitors. J Med Chem. 2012 Jan 12;55(1):169-96.
Cks85A protein, Drosophila  EC 2.7.11.22   *Cyclin-Dependent Kinases *Drosophila Proteins. Dev Biol 2011 Oct 1;358(1):213-23
7-benzylamino-5-(2-(hydroxymethyl)propyl)amino-3-isopropyl-1(2)H-pyrazolo(4,3-d)pyrimidine  0   *Pyrazoles *Pyrimidines Cyclin-Dependent Kinases/antagonists & inhibitors. J Med Chem 2011 Apr 28;54(8):2980-93
dinaciclib  0   *Pyridinium Compounds *Bicyclo Compounds, Heterocyclic Cyclin-Dependent Kinases/antagonists & inhibitors. Mol Cancer Ther 2010 Aug;9(8):2344-53
N-(6,6-dimethyl-5-((1-methylpiperidin-4-yl)carbonyl)-1,4,5,6-tetrahydropyrrolo(3,4-c)pyrazol-3-yl)-3-methylbutanamide  0   *Pyrazoles *Pyrroles Cyclin-Dependent Kinases/antagonists & inhibitors. Bioorg Med Chem 2010 Mar 1;18(5):1844-53
VER 54505  0   *Pyrazoles *Pyrimidines Cyclin-Dependent Kinases/antagonists & inhibitors. Cell Cycle 2008 Dec 15;7(24):3898-907
CR8 compound  0   *Purines *Pyridines Cyclin-Dependent Kinases/antagonists & inhibitors. Oncogene. 2008 Oct 2;27(44):5797-807
4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide  0   *Piperidines *Pyrazoles Cyclin-Dependent Kinases/antagonists & inhibitors. J Med Chem 2008 Aug 28;51(16):4986-99
CDKC;2 protein, Arabidopsis  EC 2.7.1.37   *Cyclin-Dependent Kinases *Arabidopsis Proteins. Plant Cell 2007 Apr;19(4):1388-402
CDKC;1 protein, Arabidopsis  EC 2.7.1.37   *Cyclin-Dependent Kinases *Arabidopsis Proteins. Plant Cell 2007 Apr;19(4):1388-402
AZD5438  0   *Imidazoles *Pyrimidines Cyclin-Dependent Kinases/antagonists & inhibitors. Cancer Chemother Pharmacol 2007 Aug;60(3):391-8
CDKB2;1 protein, Arabidopsis  EC 2.7.1.37   *Cyclin-Dependent Kinases *Arabidopsis Proteins. Plant Cell Physiol 2006 Dec;47(12):1683-6
CDK14 protein, human  EC 2.7.11.22   *Cyclin-Dependent Kinases. Cell Res 2006 Jun;16(6):539-47
CDKD;2 protein, Arabidopsis  EC 2.7.1.37   *Cyclin-Dependent Kinases *Arabidopsis Proteins. Plant J 2006 Sep;47(5):701-10
AG-012986  0   *Benzamides *Thiazoles Cyclin-Dependent Kinases/antagonists & inhibitors. Toxicol Pathol 2006;34(3):243-8
CDK12 protein, rat  EC 2.7.1.37   *Cyclin-Dependent Kinases. Mol Cell Biol 2006 Apr;26(7):2736-45
Cks30A protein, Drosophila  EC 2.7.1.37   *Cyclin-Dependent Kinases Protein Subunits. Development 2005 Aug;132(16):3669-78
Cdk10 protein, mouse  EC 2.7.1.37   *Cyclin-Dependent Kinases.
CDK10 protein, human  EC 2.7.1.37   *Cyclin-Dependent Kinases.
6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one  0   *Piperazines *Pyridines Cyclin-Dependent Kinases/antagonists & inhibitors. Mol Cancer Ther 2004 Nov;3(11):1427-38
olomoucine II  0   *Purines Cyclin-Dependent Kinases/antagonists & inhibitors. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3283-6
N(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine  0   2-Aminopurine/*analogs & derivatives Cyclin-Dependent Kinases/antagonists & inhibitors. Cell Cycle 2002 Mar-Apr;1(2):143-52
3-(4-methoxyphenyl)-5-(morpholinylcarbamoyl)aminoindeno(1,2-c)pyrazol-4-one  0   *Morpholines *Pyrazoles Cyclin-Dependent Kinases/antagonists & inhibitors. J Med Chem 2002 Nov 21;45(24):5224-32
TPK2 protein, Toxoplasma gondii  EC 2.7.1.-   *Cyclin-Dependent Kinases. Mol Microbiol 2002 Jul;45(2):321-32
TBPK50 protein, Trypanosoma brucei  EC 2.7.1.-   *Protozoan Proteins *Cyclin-Dependent Kinases. Mol Microbiol 2002 Jul;45(2):307-19
CDK11a protein, human  EC 2.7.11.22   *Cyclin-Dependent Kinases. J Biol Chem 1998 Jun 26;273(26):16601-7
CDK12 protein, human  EC 2.7.11.22   *Cyclin-Dependent Kinases. J Cell Sci 2001 Jul;114(Pt 14):2591-603
PSTAIRE p34 protein, Fucus  0   *Cyclin-Dependent Kinases. Development 2001 Nov;128(21):4383-92
PSTAIRE p32 protein, Fucus spiralis  0   *Cyclin-Dependent Kinases *Algal Proteins. Development 2001 Nov;128(21):4383-92
p9(Cks1) protein, human  EC 2.7.1.37   *Cyclin-Dependent Kinases. Curr Biol 2001 Jun 5;11(11):R431-5
indirubin-5-sulfonic acid  0   *Indoles *Sulfonic Acids Cyclin-Dependent Kinases/antagonists & inhibitors. Structure (Camb) 2001 May 9;9(5):389-97
CDKC protein, Lycopsersicon esculentum Mill  0   *Plant Proteins *Cyclin-Dependent Kinases. Plant Physiol 2001 Aug;126(4):1403-15
CDKB2 protein, Lycopersicon esculentum Mill  0   *Cyclin-Dependent Kinases. Plant Physiol 2001 Aug;126(4):1403-15
CDKB1 protein, Lycopersicon esculentum  EC 2.7.1.37   *Plant Proteins *Cyclin-Dependent Kinases. Plant Physiol 2001 Aug;126(4):1403-15
CDKb2;2 protein, Arabidopsis  0   *Arabidopsis Proteins *Cyclin-Dependent Kinases. J Exp Bot 2001 Jun;52(359):1381-2
CDKB1;2 protein, Arabidopsis  0   *Cyclin-Dependent Kinases *Arabidopsis Proteins. J Exp Bot 2001 Jun;52(359):1381-2
CDKA1 protein, Arabidopsis  0   *Cyclin-Dependent Kinases *Arabidopsis Proteins. FEBS Lett 1997 Aug 4;412(3):446-52
CdkB1 protein, Nicotiana tabacum  0   *Plant Proteins *Cyclin-Dependent Kinases. Plant Physiol 2001 Jul;126(3):1214-23
PD 0183812  0   *Pyridones *Pyrimidines Cyclin-Dependent Kinases/antagonists & inhibitors. J Biol Chem 2001 May 18;276(20):16617-23
NKIATRE protein, rat  EC 2.7.10.-   *Cyclin-Dependent Kinases. Genomics 2001 Jan 15;71(2):131-41
H717 compound  0   Adenine/*analogs & derivatives Cyclin-Dependent Kinases/antagonists & inhibitors. J Med Chem 2001 Feb 15;44(4):524-30
2-(4-((6,7-dihydro-7-oxo-5H-thiazolo(5,4-e)indol-8-ylidene)amino)phenylsulfamido)pyridine  0   *Indoles *Sulfonamides Cyclin-Dependent Kinases/antagonists & inhibitors. Science 2001 Jan 5;291(5501):134-7
SGV1 protein, S cerevisiae  0   *Cyclin-Dependent Kinases *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2000 Oct;20(19):7051-8
2-(2-chlorophenyl)-5,7-dihydroxy-8-(2,3,6-trihydro-1-methylpyridin-4-yl)benzopyran-4-one  0   *Chromones *Pyridines Cyclin-Dependent Kinases/antagonists & inhibitors. Bioorg Med Chem Lett 2000 May 15;10(10):1037-41
PK6 protein, Plasmodium falciparum  EC 2.7.1.-   *Protozoan Proteins *Cyclin-Dependent Kinases *Mitogen-Activated Protein Kinases. Biochem J 2000 Apr 1;347 Pt 1:255-63
Eip63E protein, Drosophila  EC 2.7.1.37   *Cyclin-Dependent Kinases *Drosophila Proteins. Dev Biol 2000 May 1;221(1):23-40
ICK2 protein, Arabidopsis  0   *Cell Cycle Proteins *Arabidopsis Proteins Cyclin-Dependent Kinases/antagonists & inhibitors. Plant J 2000 Feb;21(4):379-85
2-(2-(hydroxymethyl)pyrrolidinyl)-6-((3-iodophenyl)methylamino)-9-isopropylpurine  0   *Purines Cyclin-Dependent Kinases/antagonists & inhibitors. Bioorg Med Chem 1999 Jul;7(7):1281-93
kenpaullone  0   *Indoles *Benzazepines Cyclin-Dependent Kinases/antagonists & inhibitors. Cancer Res 1999 Jun 1;59(11):2566-9
CeReS-18 protein, Bos taurus  0   *Sialoglycoproteins Cyclin-Dependent Kinases/antagonists & inhibitors. Exp Cell Res 1998 Oct 10;244(1):295-301
PCTAIRE-2 protein kinase  EC 2.7.1.37   *Cyclin-Dependent Kinases. Eur J Biochem 1997 Oct 15;249(2):481-8
GIN4 protein, S cerevisiae  EC 2.7.11.1   *Cyclin-Dependent Kinases *Saccharomyces cerevisiae Proteins. J Cell Biol 1997 Jul 14;138(1):119-30
roscovitine  0   *Purines Cyclin-Dependent Kinases/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Protein Kinase Inhibitors 		Eur J Biochem 1997 Jan 15;243(1-2):518-26
Dacapo protein, Drosophila  0   *Nuclear Proteins *Drosophila Proteins Cyclin-Dependent Kinases/antagonists & inhibitors. Cell 1996 Dec 27:87(7):1237-47; Cell 1996 Dec 27;87(7):1225-35
L 868276  0   *Chromones *Piperidines Cyclin-Dependent Kinases/antagonists & inhibitors. Proc Natl Acad Sci U S A 1996 Apr 2;93(7):2735-40
CDKL1 protein, human  EC 2.7.11.22   *Nerve Tissue Proteins *Cyclin-Dependent Kinases CDC2 Protein Kinase. J Neurochem 1995 Dec;65(6):2577-84
CDK2AP1 protein, human  0   *Tumor Suppressor Proteins Genes, Tumor Suppressor Cyclin-Dependent Kinases. FASEB J 1995 Oct;9(13):1362-70
CKS1B protein, human  EC 2.7.1.37   *Carrier Proteins *Cyclin-Dependent Kinases. Proteins 1995 Jan;21(1):70-3
cyclin-dependent kinase 7, mouse  EC 2.7.1.37   *Cyclin-Dependent Kinases. Gene 1994 Nov 18;149(2):321-4
olomoucine  0   *Kinetin Cyclin-Dependent Kinases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		FEBS Lett 1994 Oct 17;353(2):207-11
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