encyclopedia of medical concepts
ψ 
ψ 
ψ 

MAP Kinase Kinase Kinases

More information in Books or onNLM PubMed
Definition: Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).     
See Also MAP Kinase Signaling System
Examples MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinase 3; MAP Kinase Kinase Kinase 4; MAP Kinase Kinase Kinase 5; Proto-Oncogene Proteins c-mos; raf Kinases 		Other names Mitogen Activated Protein Kinase Kinase Kinases; MAPK ERK Kinase Kinases; Kinases, MEK; Kinases, MAPK-ERK Kinase; Kinases, MAP3; Kinase Kinases, MAPK-ERK; Mitogen-Activated Protein Kinase Kinase Kinases; MAP3 Kinases; MAP Kinase Kinase Kinase; Kinases, MAP Kinase Kinase; MEKKs; MEK Kinases; MAPKKKs; MAPK-ERK Kinase Kinases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MAP3K15 protein, human  EC 2.7.11.25   *MAP Kinase Kinase Kinases. Biochem Biophys Res Commun 2010 Apr 30;395(2):213-8
Raf-1 protein, rat  EC 2.7.11.1   *MAP Kinase Kinase Kinases. Lab Invest 2010 Jan;90(1):68-82
At1g73660 protein, Arabidopsis  EC 2.7.1.37   *MAP Kinase Kinase Kinases *Arabidopsis Proteins. Plant Mol Biol 2008 May;67(1-2):125-34
MAP3Kepsilon2 protein, Arabidopsis  EC 2.7.11.25   *MAP Kinase Kinase Kinases *Arabidopsis Proteins. Plant J 2006 Oct;48(2):193-205
Wallenda protein, Drosophila  EC 2.7.1.37   *MAP Kinase Kinase Kinases *Drosophila Proteins. Neuron. 2006 Jul 6;51(1):57-69
REKS protein, Xenopus  EC 2.7.1.37   *MAP Kinase Kinase Kinases *Xenopus Proteins *Extracellular Signal-Regulated MAP Kinases.
DLK-1 protein, C elegans  EC 2.7.1.37   *MAP Kinase Kinase Kinases *Caenorhabditis elegans Proteins Leucine Zippers. Cell 2005 Feb 11;120(3):407-20
Map3k10 protein, mouse  EC 2.7.11.25   *MAP Kinase Kinase Kinases Leucine Zippers.
mlk2 protein, Xenopus  EC 2.7.1.-   *MAP Kinase Kinase Kinases *Xenopus Proteins Leucine Zippers.
Map3k8 protein, mouse  EC 2.7.11.25   *Proto-Oncogene Proteins *MAP Kinase Kinase Kinases.
Mlk1 protein, rat  EC 2.7.10.-   *MAP Kinase Kinase Kinases.
Map3k9 protein, mouse  EC 2.7.11.25   *MAP Kinase Kinase Kinases.
MAP3K2 protein, human  EC 2.7.11.25   *MAP Kinase Kinase Kinases.
YODA protein, Arabidopsis  EC 2.7.1.37   *MAP Kinase Kinase Kinases *Arabidopsis Proteins. Cell 2004 Jan 9;116(1):109-19
TNNI3K protein, human  EC 2.7.11.1   *MAP Kinase Kinase Kinases. J Mol Med. 2003 May;81(5):279-80
SSK22 protein, S cerevisiae  EC 2.7.1.37   *MAP Kinase Kinase Kinases. Biosci Biotechnol Biochem 2003 Jan;67(1):186-91
SSK2 protein, S cerevisiae  EC 2.7.1.-   *MAP Kinase Kinase Kinases *Saccharomyces cerevisiae Proteins. Mol Biol Cell 2002 Aug;13(8):2869-80
slpr protein, Drosophila  EC 2.7.10.-   *MAP Kinase Kinase Kinases *Drosophila Proteins. Genes Dev 2002 Feb 1;16(3):377-87; Mol Cell 2002 Dec;10(6):1527-33
ATMEKK1 protein, Arabidopsis  EC 2.7.1.-   *MAP Kinase Kinase Kinases *Arabidopsis Proteins. Biochem Biophys Res Commun 1998 Dec 18;253(2):532-43
MAP3K9 protein, human  EC 2.7.11.25   *MAP Kinase Kinase Kinases. Eur J Biochem 1993 Apr 15;213(2):701-10
MLTK  EC 2.7.1.-   *MAP Kinase Kinase Kinases.
MAP kinase kinase kinase ubc4  EC 2.7.10.-   *MAP Kinase Kinase Kinases. Mol Plant Microbe Interact 2000 Jul;13(7):781-6
TAO2 protein, rat  EC 2.7.10.-   *MAP Kinase Kinase Kinases. J Biol Chem 1999 Oct 1;274(40):28803-7
MAP kinase kinase kinase 7  EC 2.7.11.25   *MAP Kinase Kinase Kinases. Science 1995 Dec 22;270(5244):2008-11
MAP kinase kinase kinase 6  EC 2.7.11.25   *MAP Kinase Kinase Kinases. Biochem Biophys Res Commun 1998 Dec 9;253(1):33-7
TAO1 protein kinase  EC 2.7.1.-   *MAP Kinase Kinase Kinases. J Biol Chem 1998 Oct 30;273(44):28625-32
wis4 protein, S pombe  EC 2.7.10.-   *MAP Kinase Kinase Kinases *Schizosaccharomyces pombe Proteins. EMBO J 1997 Oct 15;16(20):6162-70
MAP3K13 protein, human  EC 2.7.11.25   *MAP Kinase Kinase Kinases Nerve Tissue Proteins Leucine Zippers. J Biol Chem 1997 Nov 7;272(45):28622-9
ANP1 kinase  EC 2.7.1.-   *MAP Kinase Kinase Kinases. Plant J 1997 Jul;12(1):39-48
Mkh1 protein, S pombe  EC 2.7.10.-   *MAP Kinase Kinase Kinases *Schizosaccharomyces pombe Proteins. Mol Cell Biol 1997 Jul;17(7):3508-19
mitogen-activated protein kinase kinase kinase 11  EC 2.7.11.25   *MAP Kinase Kinase Kinases. EMBO J 1996 Dec 16;15(24):7026-35
Pk92B protein, Drosophila  EC 2.7.1.37   *MAP Kinase Kinase Kinases *Drosophila Proteins. Gene 1996 Mar 9;169(2):283-4
MAP3K10 protein, human  EC 2.7.11.25   *MAP Kinase Kinase Kinases Leucine Zippers. Eur J Biochem 1995 Dec 1;234(2):492-500; Oncogene 1995 Apr 6;10(7):1447-51
mitogen-activated protein kinase kinase kinase 12  EC 2.7.11.25   *MAP Kinase Kinase Kinases. J Biol Chem 1994 Dec 9;269(49):30808-17
Ras-dependent mitogen-activated protein kinase kinase kinase  EC 2.7.10.-   *MAP Kinase Kinase Kinases *Extracellular Signal-Regulated MAP Kinases Proto-Oncogene Proteins c-raf. J Biol Chem 1994 Sep 16;269(37):22917-20
insulin-stimulated MEK kinase  EC 2.7.10.-   *MAP Kinase Kinase Kinases. J Biol Chem 1994 Apr 29;269(17):12804-8
NPK1 protein, Nicotiana tabacum  EC 2.7.1.-   *Plant Proteins *MAP Kinase Kinase Kinases. Mol Cell Biol 1993 Aug;13(8):4745-52
Map3k8 protein, rat  EC 2.7.11.25   *Proto-Oncogene Proteins *MAP Kinase Kinase Kinases. Mol Cell Biol. 2002 Aug;22(16):5962-74; Proc Natl Acad Sci U S A 1993 Mar 15;90(6):2251-5
BYR2 protein, S pombe  EC 2.7.1.-   *MAP Kinase Kinase Kinases *Schizosaccharomyces pombe Proteins Schizosaccharomyces. Mol Gen Genet 1992 Oct;235(1):122-30
MAP3K8 protein, human  EC 2.7.11.25   *Proto-Oncogene Proteins *MAP Kinase Kinase Kinases. Mol Cell Biol 1991;11(8):4088
STE11 protein kinase  EC 2.7.1.-   *MAP Kinase Kinase Kinases. Gene Dev 1990;4(11):1862

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy