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Calcium-Calmodulin-Dependent Protein Kinases

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Definition: A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)  general; prefer specifics; DF: CALMODULIN KINASE   
Examples Calcium-Calmodulin-Dependent Protein Kinase Kinase; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Elongation Factor 2 Kinase; Myosin-Light-Chain Kinase 		Other names Calmodulin-Dependent Protein Kinases; Ca(2+)-Calmodulin-Dependent Protein Kinase; Restricted Calcium Calmodulin Dependent Protein Ki; Protein Kinases, Calmodulin-Dependent; Protein Kinases, Calcium-Calmodulin-Dependent; Multiprotein Kinase, Calmodulin-Dependent; Multifunctional Calcium Calmodulin Dependent Prote; Calmodulin Kinase; Calmodulin Dependent Protein Kinases; Calmodulin Dependent Multiprotein Kinase; Calcium Calmodulin Dependent Protein Kinases, Rest; Calcium Calmodulin Dependent Protein Kinases, Mult; Restricted Calcium-Calmodulin-Dependent Protein Ki; Multifunctional Calcium-Calmodulin-Dependent Prote; Calmodulin-Kinase; Calmodulin-Dependent Multiprotein Kinase; Calcium-Calmodulin-Dependent Protein Kinases, Rest; Calcium-Calmodulin-Dependent Protein Kinases, Mult; Cam-MPK
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CPK12 protein, Arabidopsis  EC 2.7.11.17   *Calcium-Calmodulin-Dependent Protein Kinases *Arabidopsis Proteins. New Phytol. 2011 Oct;192(1):61-73.
CRLK1 protein, Arabidopsis  EC 2.7.11.17   *Calcium-Calmodulin-Dependent Protein Kinases *Arabidopsis Proteins. J Biol Chem 2010 Mar 5;285(10):7119-26
CMK2 protein, S cerevisiae  EC 2.7.11.17   *Calcium-Calmodulin-Dependent Protein Kinases *Saccharomyces cerevisiae Proteins. EMBO J 1991 Jun;10(6):1511-22
CPK6 protein, Arabidopsis  EC 2.7.1.123   *Calcium-Calmodulin-Dependent Protein Kinases *Arabidopsis Proteins. PLoS Biol 2006 Oct;4(10):e327
CPK3 protein, Arabidopsis  EC 2.7.1.123   *Calcium-Calmodulin-Dependent Protein Kinases *Arabidopsis Proteins. Plant Mol Biol 1996 Mar;30(6):1259-75
CaM-KIIN protein, mouse  0   *Carrier Proteins Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors Protein Isoforms. Biochem Biophys Res Commun 2006 Nov 17;350(2):444-9
camkv protein, zebrafish  EC 2.7.1.123   *Calcium-Calmodulin-Dependent Protein Kinases *Zebrafish Proteins. Dev Dyn 2006 Mar;235(3):835-42
CRCK1 protein, Arabidopsis  EC 2.7.1.123   *Calcium-Calmodulin-Dependent Protein Kinases *Arabidopsis Proteins. J Biol Chem 2004 Oct 8;279(41):42552-9
VELI-2 protein, rat  EC 2.7.4.-   *Nerve Tissue Proteins *Calcium-Calmodulin-Dependent Protein Kinases. J Biol Chem. 2004 Apr 30;279(18):19051-63
VELI-1 protein, rat  EC 2.7.4.-   *Nerve Tissue Proteins *Calcium-Calmodulin-Dependent Protein Kinases. J Biol Chem. 2004 Apr 30;279(18):19051-63
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide  0   *Benzamides Calcium-Calmodulin-Dependent Protein Kinases. Nat Med 1999 Jul;5(7):810-6
SB 218655  0   *Imidazoles *Pyrimidines Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors. Structure 1998 Sep 15;6(9):1117-28
SB 216995  0   *Imidazoles *Pyrimidines Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors. Structure 1998 Sep 15;6(9):1117-28
CaM-KIIN protein, human  0   *Carrier Proteins Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors. Proc Natl Acad Sci U S A 1998 Sep 1;95(18):10890-5
TPK3 kinase protein, Toxoplasma  EC 2.7.10.-   *Protozoan Proteins *Calcium-Calmodulin-Dependent Protein Kinases. Mol Biochem Parasitol 1998 Jun 1;93(2):273-83
SB 220025  0   *Imidazoles *Pyrimidines Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors. J Pharamcol Exp Ther 1998 Feb;284(2):687-92
calmodulin dependent protein kinase II phosphatase  EC 3.1.3.-   *Phosphoprotein Phosphatases Calcium-Calmodulin-Dependent Protein Kinases. J Biol Chem 1998 Jan 23;273(4):1904-10
CCK1 protein, Chlamydomonas moewusii  EC 2.7.10.-   *Plant Proteins *Calcium-Calmodulin-Dependent Protein Kinases. Planta 1997;202(1):76-84
CDKL2 protein, human  EC 2.7.11.22   *Calcium-Calmodulin-Dependent Protein Kinases. Oncogene 1996 Dec 19;13(12):2563-74
CPK9 protein, Arabidopsis  EC 2.7.1.123   *Calcium-Calmodulin-Dependent Protein Kinases *Arabidopsis Proteins. Proc Natl Acad Sci U S A 1996 Jul 23;93(15):8145-50
Caki protein, Drosophila  EC 2.7.10.-   *Calcium-Calmodulin-Dependent Protein Kinases *Drosophila Proteins. EMBO J 1996 Apr 15;15(8):1865-76
RGS4 protein  175335-35-0   *RGS Proteins Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors. Nature 1996 Feb 22;379(6567):742-6
calcium-calmodulin-activated histone 3 arginine kinase  EC 2.7.10.-   *Calcium-Calmodulin-Dependent Protein Kinases. J Biol Chem 1995 Sep 29;270(39):23155-8
PD 98059  0   *Flavonoids Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors. J Biol Chem 1995 Jun 9;270(23):13585-8
farnesylthiosalicylic acid  0   *Salicylic Acids Farnesol/*analogs & derivatives Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors 		J Med Chem 1995 Apr 14;38(8):1267-72
death-associated protein kinase  EC 2.7.11.1   *Calcium-Calmodulin-Dependent Protein Kinases *Apoptosis Regulatory Proteins. Genes Dev 1995 Jan 1;9(1):15-30
MS 282b  0   *Furans Myosin-Light-Chain Kinase/antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Aug;47(8):855-61
MS 282a  0   *Furans Myosin-Light-Chain Kinase/antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Aug;47(8):855-61
calmodulin-dependent protein kinase V  EC 2.7.10.-   *Calcium-Calmodulin-Dependent Protein Kinases. Arch Biochem Biophys 1994 Jul;312(1):278-84
Rolled protein, Drosophila  EC 2.7.10.-   *Calcium-Calmodulin-Dependent Protein Kinases *Drosophila Proteins *Extracellular Signal-Regulated MAP Kinases. EMBO J 1994 Apr 1;13(7):1628-35
rottlerin  82-08-6   *Acetophenones *Benzopyrans Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		FEBS Lett 1994 Jan 24;338(1):85-8
ste11 protein, S pombe  145139-18-0   *Transcription Factors *Schizosaccharomyces pombe Proteins Calcium-Calmodulin-Dependent Protein Kinases. Genes Dev 1991;5(11):1990
KN 62  127191-97-3 5-Isoquinolinesulfonic acid, 4-(2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenyl ester, (S)  1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Biol Chem 1990;265(8):4315
myosin-heavy-chain kinase  EC 2.7.1.129   *Protozoan Proteins *Calcium-Calmodulin-Dependent Protein Kinases. J Biol Chem 1981;256(24):12811
W 7  65595-90-6   *Sulfonamides Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Vasodilator Agents 		J Pharmacol 207(1):8;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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