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Prostaglandin D2

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Definition: The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.  /biosyn /physiol permitted; DF: PGD2    Other names PGD2; 11-Dehydroprostaglandin F2alpha; alpha, 11-Dehydroprostaglandin F2; F2alpha, 11-Dehydroprostaglandin; F2 alpha, 11-Dehydroprostaglandin; D2, Prostaglandin; 11 Dehydroprostaglandin F2alpha; 11 Dehydroprostaglandin F2 alpha; 11-Dehydroprostaglandin F2 alpha
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
levuglandin D2  0   Prostaglandin D2/*analogs & derivatives. Biochemistry. 2001 Jun 12;40(23):6948-55.
10T024A compound  0   *Phenazines Leukotriene B4/antagonists & inhibitors Prostaglandin D2/antagonists & inhibitors. Biosci Biotechnol Biochem. 2011;75(10):2056-8.
15-deoxy-9,10-dihydro-delta(12,14)-prostaglandin J2  0   Prostaglandin D2/*analogs & derivatives. Cell Mol Life Sci 2008 Nov;65(21):3507-19
15R-methyl prostaglandin D2  0   Prostaglandin D2/*analogs & derivatives. J Org Chem. 2008 Sep 19;73(18):7213-8
11,15-dioxo-9-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid  0   Prostaglandin D2/*analogs & derivatives. J Biol Chem 2008 Jan 11;283(2):1179-88
TS-002  0   *Prostaglandin D2. J Drug Target 2007 Jan;15(1):59-66
11-methyleneprostaglandin D2  0   Prostaglandin D2/*analogs & derivatives. J Pharmacol Exp Ther 2007 Jan;320(1):173-9
delta(12)-prostaglandin J(2)  0   *Prostaglandin D2. Exp Mol Med 2004 Oct 31;36(5):444-53
15-deoxyprostaglandin J2  0   Prostaglandin D2/*analogs & derivatives. Surgery 2003 Aug;134(2):206-12
15-methylprostaglandin D2  85280-90-6   Prostaglandin D2/*analogs & derivatives. J Pharmacol Exp Ther 2003 Jan;304(1):349-55
NEPP11 compound  0   Prostaglandin D2/*analogs & derivatives. J Neurochem 2001 Apr;77(1):50-62
15-deoxy-delta(12,14)-prostaglandin J2  0   Prostaglandin D2/*analogs & derivatives.
Pharma Action Immunologic Factors 		Cell 1995 Dec 1;83(5):803-12
prostaglandin D2 4-azidophenacyl ester  0   *Azides Prostaglandin D2/*analogs & derivatives. Bioconjug Chem 1990;1(5):363
anhydrolevulgandin D2  114601-85-3   *Prostaglandin D2 Uterine Contraction. Prostaglandins 1988;35(1):115
prostaglandin D2 methyl ester  49852-81-5   Prostaglandin D2/*analogs & derivatives. Biochim Biophys Acta 1987;917(2):224
11-methoxime prostaglandin D2  130377-58-1   *Prostaglandins, Synthetic Prostaglandin D2/*analogs & derivatives. Prostaglandins 1986;31(1):123
9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2  87893-54-7   *Prostaglandin D2.
Pharma Action Antineoplastic Agents ; Antiviral Agents 		Proc Natl Acad Sci USA 1984;81(5):1317
9-deoxy-delta-9-prostaglandin D2  60203-57-8 Prosta-5,9,13-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,13E,15S)  Prostaglandin D2/*analogs & derivatives Prostaglandins, Synthetic.
Pharma Action Antineoplastic Agents 		Biochem Biophys Res Commun 1982;109(3):626
prostaglandin D2 receptor  0   *Receptors, Immunologic *Receptors, Prostaglandin Pregnancy Proteins Prostaglandin D2. Biochem Biophys Res Commun 2003 Aug 8;307(4):797-802; Gene 1999 Feb 4;227(1):71-7; J Biol Chem 1982;257(22):13570
13,14-dihydro-15-ketoprostaglandin D2  59894-07-4 Prost-5-en-1-oic acid, 9-hydroxy-11,15-dioxo-, (5Z,9alpha)  Prostaglandin D2/*analogs & derivatives. Endocrinology 1982;110(6):2207

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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