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Leukotriene C4

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Definition: The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)  /biosyn /physiol permitted; DF: note short X ref    Other names LTC4; Leukotriene C 4; Leukotriene C 1; Leukotrienes C; Leukotriene C1; Leukotriene C-4; Leukotriene C-1; Leukotriene C
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-methylleukotriene C4  0   Leukotriene C4/*analogs & derivatives Receptors, Leukotriene/agonists. Mol Pharmacol 2011 Feb;79(2):270-8
leukotriene C4-iodo-4-azidosalicylic acid  0   *Salicylates Leukotriene C4/*analogs & derivatives Iodine Radioisotopes. J Biol Chem 1997 Apr 18;272(16):10936-40
leukotriene C4 monomethyl ester  73958-10-8 Glycine, N-(N-L-gamma-glutamyl-S-(1-(1-hydroxy-5-methoxy-5-oxopentyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))  Leukotriene C4/*analogs & derivatives. FEBS Lett 1984;175(2):289

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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