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Receptors, Glucocorticoid

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Definition: Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.  coord IM with specific glucocorticoid (IM); DF: RECEPT GLUCOCORTICOID    Other names Glucocorticoid Receptors; Receptor, Glucocorticoid; Receptor, Corticoid II; Glucocorticoids Receptors; Corticoid II Receptors; Receptors, Glucocorticoids; Receptors, Corticoid Type II; Receptors, Corticoid II; Glucocorticoid Receptor; Corticoid Type II Receptors; Corticoid II Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
glucocorticoid-induced transcript 1 protein, zebrafish  0   *Receptors, Glucocorticoid. J Am Soc Nephrol. 2011 Nov;22(11); 2037-46
glucocorticoid-induced transcript 1 protein, mouse  0   *Receptors, Glucocorticoid. J Am Soc Nephrol. 2011 Nov;22(11); 2037-46
glucocorticoid-induced transcript 1 protein, human  0   *Receptors, Glucocorticoid. N Engl J Med. 2011 Sep 29;365(13):1173-83
CORT 108297  0   *Aza Compounds *Heterocyclic Compounds with 4 or More Rings Receptors, Glucocorticoid/antagonists & inhibitors. Diabetes Obes Metab. 2010 Jun;12(6):545-7
1,1,1-trifluoro-4-(2-methoxy-5-pyrimidin-5-ylphenyl)-4-methyl-2-(1H-pyrrolo(2,3-c)pyridin-2-ylmethyl)pentan-2-ol  0   *Pyridines *Pyrroles Receptors, Glucocorticoid/agonists. J Med Chem 2010 Sep 23;53(18):6681-98
4-fluoro-2-(4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-3-(1H-pyrrolo(2,3-c)pyridin-2-ylmethyl)butyl)phenol  0   *Pyridines *Pyrroles Receptors, Glucocorticoid/agonists. J Med Chem 2010 Sep 23;53(18):6681-98
MDG 169  0   *Dibenzazepines Receptors, Glucocorticoid/antagonists & inhibitors. J Med Chem 2010 Apr 22;53(8):3065-74
9-(2-methylindol-3-yl)-4a-morpholino-7-nitro-1,2,3,4,4a,9a-hexahydroxanthene  0   *Indoles *Xanthenes Receptors, Glucocorticoid/antagonists & inhibitors. Biochem Biophys Res Commun 2010 Jan 15;391(3):1531-6
R-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-(((2-methyl-5-quinolyl)amino)methyl)pentan-2-ol  0   *Pentanols *Benzofurans *Quinolines Receptors, Glucocorticoid/agonists.
NR3C1 protein, rat  0   *Receptors, Glucocorticoid. Biol Reprod. 2009 Jun;80(6):1209-15
Org 34517  0   *Steroids *Benzodioxoles Receptors, Glucocorticoid/antagonists & inhibitors. Neuropsychopharmacology 2003 Jun;28(6):1056-67
Org 34850  0   *Steroids *Sulfones Receptors, Glucocorticoid/antagonists & inhibitors. Neuropsychopharmacology 2003 Jun;28(6):1056-67
CP 472555  0   *Phenanthrenes *Pyridines Receptors, Glucocorticoid/antagonists & inhibitors. Neuroscience 2006 Jun 30;140(2):555-65
NR3C1 protein, human  0   *Receptors, Glucocorticoid. Nature 1985 Dec 19-1986 Jan 1;318(6047):635-41
GRgamma protein, human  0   *Receptors, Glucocorticoid. Clin Endocrinol (Oxf). 2004 Sep;61(3):327-31
Ifngr2 protein, mouse  0   *Receptors, Interferon Receptors, Glucocorticoid.
4a-benzyl-2-chloroethynyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-2,7-diol  0   *Phenanthrenes Receptors, Glucocorticoid/antagonists & inhibitors. J Med Chem 2002 Jun 6;45(12):2417-24
4a-benzyl-2-prop-1-ynyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-2,7-diol  0   *Phenanthrenes Receptors, Glucocorticoid/antagonists & inhibitors. J Med Chem 2002 Jun 6;45(12):2417-24
glucocorticoid receptor alpha  0   *Receptors, Glucocorticoid. Mol Psychiatry 2000 Mar;5(2):196-202
glucocorticoid receptor beta  0   *Receptors, Glucocorticoid. J Biol Chem 1999 Sep 24;274(39):27857-66
21-hydroxy-6,19-oxidoprogesterone  0   Progesterone/*analogs & derivatives Receptors, Glucocorticoid/antagonists & inhibitors. Mol Pharmacol 1997 Oct;52(4):749-54
2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine  0   *Acetates Tyramine/*analogs & derivatives Receptors, Glucocorticoid/agonists. Biochem Pharmacol 1997 Jan 24;53(2):189-97
IFNGR2 protein, human  0   *Receptors, Interferon Receptors, Glucocorticoid. Cell 1994 Mar 11;76(5):793-802
triamcinolone acetonide receptor  0   *Receptors, Glucocorticoid Triamcinolone Acetonide. Gen Comp Endocrinol 1983;51(2):228
pregnenolone receptor  0   *Receptors, Glucocorticoid Pregnenolone. Biochim Biophys Acta 1983;755(1):40
prednisolone receptor  0   *Receptors, Glucocorticoid Prednisolone. Biochem Med 1981;25(1):34
hydrocortisone receptor  0   *Receptors, Glucocorticoid Hydrocortisone. Biochem Biophys Res Commun 1981;98(3):701; Vopr Med Khim 1980;26(5):656
dexamethasone receptor  0   *Receptors, Glucocorticoid. Biochemistry 1980;19(26):6162
1 alpha-hydroxycorticosterone receptor  0   *Receptors, Glucocorticoid. Gen Comp Endocrinol 1980;42(2):259

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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