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Dacarbazine
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Definition
: An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
Pharmacological Action
Antineoplastic Agents, Alkylating
Other names
DTIC; NSC45388; NSC 45388; Imidazole Carboxamide, Dimethyl; DTICDome; DTIC Dome; Carboxamide, Dimethyl Imidazole; NSC-
45388; Dimethyl Triazeno Imidazole Carboxamide; Dimethyl Imidazole Carboxamide; Deticene; Decarbazine; DTIC-
Dome; Biocarbazine; 5-
(3,3-
Dimethyl-
1-
triazeno)imidazole-
4-
carboxamide; DIC; ICDT
Drugs
*
:
DACARBAZINE
;
DTIC-DOME
Substance
CAS Registry & name
Categories
Source
Drugs
*
temozolomide hexyl ester
0
Dacarbazine/*analogs & derivatives
Prodrugs.
J Pharm Pharmacol 2007 Jun;59(6):787-94
COPP-
ABVD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Cyclophosphamide
Dacarbazine
Doxorubicin
Prednisone
Procarbazine
Vinblastine
Vincristine.
Pediatr Blood Cancer 2007 Aug;49(2):139-44
DMAP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Dacarbazine
Doxorubicin
Mitomycin.
Cancer Invest 2002;20(5-6):605-12
DBPT regimen
0
*Antineoplastic Combined Chemotherapy Protocols
Carmustine
Cisplatin
Dacarbazine
Tamoxifen.
Br J Cancer 2000 Jun;82(11):1759-63
EBVD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Vinblastine
Epirubicin.
Leuk Lymphoma 2000 Mar;37(1-2):131-43
CYVEDIC protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Dacarbazine
Vincristine
Epirubicin.
Tumori 1999 Nov-Dec;85(6):512-4
DBCT protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Carmustine
Cisplatin
Dacarbazine
Tamoxifen.
Br J Cancer 2000 Mar;82(6):1158-62
FDE protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Dacarbazine
Fluorouracil
Epirubicin.
Cancer 1998 Jul 15;83(2):372-8
DTIC-
LVFU2 protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Leucovorin
Dacarbazine
Fluorouracil.
Am J Clin Oncol 1998 Jun;21(3):237-40
VACAD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Dacarbazine
Dactinomycin
Doxorubicin
Vincristine.
Med Pediatr Oncol 1998 Apr;30(4):201-9
ABOD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Doxorubicin
Vincristine.
Acta Oncol 1996;35(Suppl 8):73-80
ABVDP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Doxorubicin
Prednisone
Vinblastine.
Leuk Lymphoma 1996 Mar;21(1-2):79-84
1,4-
dihydro-
7,8-
dimethyl-
6H-
pyrimido(1,2-
b)-
1,2,4,5-
tetrazin-
6-
one
0
Dacarbazine/*analogs & derivatives.
Biochemistry 1996 May 7;35(18):5847-55
EID protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Dacarbazine
Ifosfamide
Epirubicin.
Am J Clin Oncol 1996 Feb;19(1):78-81
DVP protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Dacarbazine
Vindesine.
Am J Clin Oncol 1994 Feb;17(1):55-9
CyADIC regimen
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Dacarbazine
Doxorubicin.
J Clin Oncol 1992 Aug;10(8):1266-77
IVADIC regimen
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Dacarbazine
Doxorubicin
Ifosfamide
Vincristine.
Cancer Chemother Pharmacol 1992;30(2):100-4
DBPT protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Carmustine
Cisplatin
Dacarbazine
Tamoxifen.
Oncology (Williston Park) 1991;5(5):95
MAID protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Dacarbazine
Doxorubicin
Ifosfamide.
J Clin Oncol 1989;7(9):1208
FIVB+P protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Carmustine
Dacarbazine
Fluorouracil
Prednisone
Vincristine.
Dtsch Med Wochenschr 1989;114(24):935
PADIC protocol
0
Cisplatin
*Antineoplastic Combined Chemotherapy Protocols
Dacarbazine
Doxorubicin.
Cancer 1989;63(11):2115
BOLD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Lomustine
Vincristine.
Cancer 1989;63(9):1676
CADOM protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Dacarbazine
Doxorubicin
Methotrexate
Vincristine.
Isr J Med Sci 1988;24(9-10):599
CVD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Dacarbazine
Vincristine.
Ann Intern Med 1988;109(4):267
ABV-
ADV protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Dactinomycin
Doxorubicin
Vinblastine
Vincristine.
Am J Med 1987;82(3):456
VDD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Dacarbazine
Vinblastine.
Cancer Treat Rep 1986;70(3):329
VADIC protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Dacarbazine
Doxorubicin
Vincristine.
Surg Gynecol Obstet 1986;162(2):193
ethazolastone
97716-74-0
Dacarbazine/*analogs & derivatives.
Biochem Pharmacol 1986;35(2):311
temozolomide
85622-93-1
Dacarbazine/*analogs & derivatives.
Pharma Action
Antineoplastic Agents, Alkylating
Br J Cancer 1985;52(5):789
TEMODAR
;
TEMOZOLOMIDE
BELD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Lomustine
Vindesine.
Cancer 1985;55(9):1879
MADDOC protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Cyclophosphamide
Dacarbazine
Doxorubicin
Mechlorethamine
Vincristine.
Radiother Oncol 1985:2(3):189
ADIC protocol
0
Doxorubicin
*Antineoplastic Combined Chemotherapy Protocols
Dacarbazine.
Am J Clin Oncol 1984;7(5):539
5-
(3-
(2-
chloroethyl)triazen-
1-
yl)imidazole-
4-
carboxamide
28177-14-2
Dacarbazine/*analogs & derivatives.
Cancer Res 1984;44(5):1767
ABDIC protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Doxorubicin
Lomustine
Prednisone.
J Clin Oncol 1983;1(7):432
B-
DOPA protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Doxorubicin
Prednisone
Vincristine.
Pol Tyg Lek 1983;38(42-43):1301
DECAV protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Dacarbazine
Cyclophosphamide
Doxorubicin
Vindesine.
Sem Hop Paris 1983;59(19):1441
DAV protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Dacarbazine
Vincristine
Nimustine.
Gan To Kagaku Ryoho 1982;9(11):1942
VABCD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Doxorubicin
Lomustine
Vinblastine.
Cancer 1983;51(8):1348
CYOMAD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Leucovorin
Cyclophosphamide
Dacarbazine
Doxorubicin
Methotrexate
Vincristine.
Cancer 1982;50(9):1724
CYVADIC protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Dacarbazine
Doxorubicin
Vincristine.
Int Adv Surg Oncol 1982;5:93
ABVD protocol
0
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Dacarbazine
Doxorubicin
Vinblastine.
Rev Med Brux 1982;3(4):223
5-
(3-
hydroxymethyl-
3-
methyl-
1-
triazeno)imidazole-
4-
carboxamide
75513-70-1 1H-
Imidazole-
4-
carboxamide, 5-
(3-
(hydroxymethyl)-
3-
methyl-
1-
triazenyl)
Dacarbazine/*analogs & derivatives.
Cancer Lett 1980;10(3):235
5-
(3,3-
dimethyl-
1-
triazeno)-
1-
methylimidazole-
4-
carboxamide
76283-04-0 1H-
Imidazole-
4-
carboxamide, 5-
(3,3-
dimethyl-
1-
triazenyl)-
1-
methyl
Dacarbazine/*analogs & derivatives.
Cancer Lett 1980;10(3):235
5-
(3-
methyl-
1-
triazeno)imidazole-
4-
carboxamide
3413-72-7
Dacarbazine/*analogs & derivatives.
Pharma Action
Alkylating Agents
Biochem Pharmacol 24(5):615;1975; Biochem Pharmacol 25(23):2643;1976