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Immunoglobulin Variable Region

More information in Books or onNLM PubMed
Definition: That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.  DF: IG VARIABLE REGION   
Pharmacological Action Immunologic Factors
See Also Binding Sites, Antibody
Examples Complementarity Determining Regions; Immunoglobulin Joining Region; Single-Chain Antibodies 		Other names Variable Region, Immunoglobulin; Variable Region, Ig; Variable Regions, Immunoglobulin; Regions, Immunoglobulin Variable; Immunoglobulin Variable Regions; Immunoglobulin Framework Regions; Variable Regions, Ig; Ig Variable Regions; Ig Framework Regions; Framework Regions, Immunoglobulin; Framework Regions, Ig; Framework Region, Ig; Immunoglobulin V; Immunoglobulin Framework Region; Ig Variable Region; Ig Framework Region; Framework Region, Immunoglobulin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1D4.1-325 DVD-Ig protein  0   *Antibodies, Monoclonal *Immunoglobulin Variable Region. Nat Biotechnol 2007 Nov;25(11):1290-7
CD40LIg fusion protein  0   *Recombinant Fusion Proteins Immunoglobulin Variable Region Antigens, CD40. Transplant Proc 2007 Dec;39(10):3436-7
PTH22 protein, Lama glama  0   *Immunoglobulin Variable Region. J Immunol Methods 2005 Feb;297(1-2):213-24
scFvC54-sTRAIL fusion protein  0   *Recombinant Fusion Proteins *Single-Chain Antibodies Immunoglobulin Variable Region. Neoplasia 2004 Sep-Oct;6(5):636-45
FcRepsilon51 protein, human  0   *Immunoglobulin Variable Region. J Biochem (Tokyo) 2003 Jan;133(1):43-9
IL-15-Fcgamma2a protein, human  0   *Recombinant Fusion Proteins *Interleukin-15 Immunoglobulin Variable Region. J Immunol 2001 Sep 15;167(6):3478-85
RASA protein, human  0   *Immunoglobulin Variable Region *Recombinant Proteins. Hum Reprod 2001 Sep;16(9):1854-60
anti-quadruplex DNA scFv  0   *Antibodies, Antinuclear *Single-Chain Antibodies DNA-Binding Proteins Immunoglobulin Variable Region. Biochemistry 1998 Nov 17;37(46);16316-24
anti-HIV-1 Rev SFv  0   *Immunoglobulin Variable Region Recombinant Proteins rev Gene Products, Human Immunodeficiency Virus. Hum Gene Ther 1994 Nov;5(11):1315-24
immunocorticotropin  150035-99-7 L-Valine, N-(N2-(N-(N-(N-(N-(1-(N2-(N2-L-valyl-L-lysyl)-L-lysyl)-L-prolyl)glycyl)-L-seryl)-L-seryl)-L-valyl)-L-lysyl)  *Immunoglobulin G *Peptide Fragments Adrenocorticotropic Hormone Immunoglobulin Variable Region Immunoglobulin Heavy Chains. Int J Pept Protein Res 1993 Jun;41(6):517-21
ID 32-44  0   *Immunoglobulin Variable Region. Adv Exp Med Biol 1989;251:129
immunoglobulin Fv  0   *Immunoglobulin Fragments Immunoglobulin Variable Region Recombinant Proteins. Science 1988;240(4855):1038

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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