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Dioxins

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Definition: Chlorinated hydrocarbons containing heteroatoms that are present as contaminants of herbicides. Dioxins are carcinogenic, teratogenic, and mutagenic. They have been banned from use by the FDA.     
Examples Dioxanes; Tetrachlorodibenzodioxin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-phloroeckol  0   *Dioxins Monophenol Monooxygenase/antagonists & inhibitors. J Agric Food Chem. 2009 May 27;57(10):4124
4-hydroxy-4a,7-dimethoxy-4,4a-dihydrodibenzo-p-dioxin-2(3H)-one  0   *Dioxins. Fitoterapia. 2009 Jun;80(4):226-9
2,7,4a-trimethoxy-1,4,4a,8b-tetrahydrodibenzo-p-dioxin-4-one  0   *Dioxins. J Asian Nat Prod Res. 2010 Aug;12(8):719-22
dioxinodehydroeckol  0   *Dioxins AMP-Activated Protein Kinases/antagonists & inhibitors. Chem Biol Interact 2010 Jun 7;186(1):24-9
2-isopropenyl-6-acetyl-8-methoxy-1,3-benzodioxin-4-one  0   *Dioxins. Phytother Res. 2010 Mar;24(3):451-3
5-(2-chloroethoxy)-2,3-dihydro-1,4-benzodioxine  0   *Dioxins. Acta Crystallogr C. 2009 Aug;65(Pt 8):o396-9
5-(2-bromoethoxy)-2,3-dihydro-1,4-benzodioxine  0   *Dioxins. Acta Crystallogr C. 2009 Aug;65(Pt 8):o396-9
2,3-dihydrobenzo(1,4)dioxin  0   *Dioxins. Bioorg Med Chem 2007 Jun 15;15(12):4048-56
ventol  0   *Dioxins *Phenols. Res Commun Mol Pathol Pharmacol. 2004;115-116():77-79
phlorofucofuroeckol B  0   *Benzofurans *Dioxins. Biosci Biotechnol Biochem 2006 Nov;70(11):2807-11
PHA-568487E  0   *Aza Compounds *Dioxins. J Chromatogr A. 2006 Sep 15;1127(1-2):286-94
dibenzodioxin  0   *Dioxins. Langmuir. 2005 Apr 26;21(9):3877-80
dichlorodibenzo-p-dioxin  0   *Dioxins. Anal Bioanal Chem. 2005 Mar;381(6):1294-8
N-(1-(2,3-dihydro(1,4)dioxin-5-yl)piperidi-4-yl)indan-2-ylamine  0   *Dioxins *Piperidines. Br J Pharmacol 2003 Mar;138(6):1077-84
2,3-dichlorodibenzo-4-dioxin  0   *Dioxins. Chemosphere 2002 Nov;49(5):485-91
2,4,5,7,8-pentamethyl-4H-1,3-benzodioxin-6-ol  0   *Dioxins. J Org Chem 2002 May 31;67(11):3607-14
spongiadioxin C, methyl ether  0   *Dioxins *Hydrocarbons, Brominated. J Nat Prod 2002 Aug;65(8):1213-5
spongiadioxin C  0   *Dioxins *Hydrocarbons, Brominated. J Nat Prod 2002 Aug;65(8):1213-5
1,2,6,7-tetrachlorodibenzo-p-dioxin  0   *Dioxins. Chemosphere 2002 Jan;46(4):507-10
6-bromomethyl-4H-1,3-dioxin  0   *Dioxins. J Am Chem Soc 2002 Feb 6;124(5):754-5
1,3,5-trimethyl-6-((3-(4-((2,3-dihydro-2-hydroxymethyl)-1,4-benzodioxin-5-yl)-1-piperazinyl)propyl)amino)-2,4(1H,3H)-pirymidinedione  0   *Dioxins *Pyrimidinones. Naunyn Schmiedebergs Arch Pharmacol 2001 Jun;363(6):649-62
spongiadioxin B  0   *Dioxins. J Nat Prod 2001 Feb;64(2):151-3
spongiadioxin A  0   *Dioxins. J Nat Prod 2001 Feb;64(2):151-3
6-(2-(R)-((2-(R)-(3-chlorophenyl)-2-hydroxyethyl)amino)propyl)-2,3-dihydro-1,4-benzodioxine-2-(R)-carboxylic acid  0   *Carboxylic Acids *Dioxins. Tohoku J Exp Med 2000 Nov;192(3):181-93
4,9-dichlorodibenzodioxin  0   *Dioxins Xanthine Oxidase/analogs & derivatives. Biochemistry (Mosc) 2000 Aug;65(8):972-5
PD 161721  0   *Dioxins Receptors, Endothelin/antagonists & inhibitors. Cardiovasc Res 1998 Sep;39(3):625-32
S 18126  0   *Dioxins *Piperazines Receptors, Dopamine/antagonists & inhibitors. J Pharmacol Exp ther 1998 Oct;287(1):167-86
dibenzo-1,4-dioxin-2-carboxylic acid  0   *Dioxins. FEMS Microbiol Lett 1996 May 1;138(2-3):105-11
mephendioxan  0   *Dioxins. J Med Chem 1996 May 24;39(11):2253-8
2,3,7,8-tetrafluorodibenzodioxin  0   *Dioxins. Chemosphere 1995 Feb;30(4):629-39
cladospirone bisepoxide  155866-40-3 Spiro02a,6a-epoxynaphth02,3-b)oxirene-2(1aH),2'-naphtho01,8-de)01,3)dioxin)-3(6H)-one, 7,7a-dihydro-6,7-dihydroxy-, 01aR-(1aalpha,2abeta,6alpha,6abeta,7beta,7aalpha))  *Dioxins *Spiro Compounds. J Antibiot (Tokyo) 1994 Oct;47(10):1098-103
5H-(2)benzopyrano(3,4-g)(1,4)benzodioxin-5-one  128650-18-0   *Coumarins *Dioxins Photochemotherapy. J Photochem Photobiol B 1993 Jul;19(2):119-24
plakinidone  137319-23-4 1,2-Dioxin-3(6H)-one, 5-hydroxy-6-(10-(4-hydroxyphenyl)-6-methyldecyl)-4,6-dimethyl  Dioxins Lactones. J Nat Prod 1991 Sep-Oct;54(5):1451-4
2,2-dimethyl-4-oxo-6-methoxybenzo-1,3-dioxin  82944-21-6   *Dioxins. Farmaco 1991;46(5):677
2,8-dichlorodibenzo-4-dioxin  38964-22-6   *Dioxins. Biochem Pharmacol 1991;41(12):1931
2,3,7,8-tetrabromodibenzo-4-dioxin  50585-41-6   *Dioxins. Toxicol Appl Pharmacol 1991;107(1):141
NK 252  126444-11-9   *Dihydropyridines *Dioxins. Jpn J Cancer Res 1990;81(10):1057
phlorofucofuroeckol A  128129-56-6 Benzo(b)benzofuro(3,2-f)(1,4)benzodioxin-1,3,6,10,12-pentol, 4,9-bis(3,5-dihydroxyphenoxy)  *Benzofurans *Dioxins alpha-2-Antiplasmin. Chem Pharm Bull (Tokyo) 1990;38(1):133
N-((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)-5-methoxy-1H-indole-3-ethanamine  116729-30-7   *Dioxins *Tryptamines Receptors, Serotonin. Eur J Pharmacol 1989;173(2-3):189
binospirone mesylate  124756-23-6 8-Azaspiro(4.5)decane-7,9-dione, 8-(2-(((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)amino)ethyl)-, monomethanesulfonate  *Dioxins *Spiro Compounds.
Pharma Action Serotonin Antagonists ; Anti-Anxiety Agents ; Serotonin Receptor Agonists 		Eur J Pharmacol 1989;173(2-3):189
8,8'-bieckol  89445-12-5 (2,2'-Bidibenzo(b,e)(1,4)dioxin)-1,1',3,3',6,6',8,8'-octol, 9,9'-bis(3,5-dihydroxyphenoxy)  *Dioxins. Chem Pharm Bull (Tokyo) 1989;37(9):2438
2-O-(2,4,6-trihydroxyphenyl)-6,6'-bieckol  89079-38-9   *Dioxins. Chem Pharm Bull (Tokyo) 1989;37(9):2438
6,6'-bieckol  88095-81-2 (1,1'-Bidibenzo(b,e)(1,4)dioxin)-2,2',4,4',7,7',9,9'-octol, 6,6'-bis(3,5-dihydroxyphenoxy)  *Dioxins. Chem Pharm Bull (Tokyo) 1989;37(9):2438
eckol  88798-74-7   *Dioxins. Chem Pharm Bull 1989;37(2):349
2-iodo-7,8-dibromodibenzo-1,4-dioxin  117333-18-3   *Dioxins Iodine Radioisotopes. Mol Pharmacol 1988;34(2):229
isoamericanin A  69506-79-2   *Dioxins. Chem Pharm Bull (Tokyo) 1987;35(9):3603
americanin A  0   *Dioxins. Chem Pharm Bull (Tokyo) 1987;35(9):3603
2-azido-3-iodo-7,8-dibromodibenzo-1,4-dioxin  106463-72-3   *Dioxins Iodine Radioisotopes. Arch Biochem Biophys 1988;261(1):103
CGS 10078B  81737-62-4 1,4-Benzodioxin-2-methanol, alpha,alpha'-(iminobis(methylene))bis(2,3-dihydro)-, stereoisomer, methanesulfonate (salt)  *Dioxins. Am J Med Sci 1985;290(2):47
1,4-dioxin  290-67-5   *Dioxins. Arh Hig Rada Toksikol 1982;3(4):343
2-nitrodibenzo-4-dioxin  38178-41-5   *Dioxins. Drug Chem Toxicol 1983;6(1):71
2,3-dichloro-7-nitrodibenzo-4-dioxin  71721-78-3   *Dioxins. Drug Chem Toxicol 1983;6(1):71
2,3,7-tribromobenzo-4-dioxin  51974-40-4   *Dioxins. Toxicol Lett 1983;15(2-3):259
2,4-bis(trichloromethyl)-benzo(1,3)dioxin-6-carboxylic acid  61720-31-8 4H-1,3-Benzodioxin-6-carboxylic acid, 2,4-bis(trichloromethyl)  *Dioxins. Br J Nutr 1982;47(3):565
ICI 111075  61719-77-5 4H-1,3-Benzodioxin-6-carboxylic acid, 4-(dichloromethylene)-2-(trichloromethyl)  *Dioxins. Br J Nutr 1981;45(3):567
2-chlorodibenzo-4-dioxin  39227-54-8   *Dioxins. J Environ Sci Health (B) 1980;B15(5):571
dibenzo(1,4)dioxin  262-12-4 dibenzo(b,e)(1,4)dioxin  *Dioxins. Biochem J 180(3):639;1979
diphenylene dioxide 2,3-quinone  6859-47-8 dibenzo(b,e)(1,4)dioxin-2,3-dione  *Dioxins *Benzoquinones. Arch Biochem Biophys 155(2):247;1973
2,7-dichlorodibenzo-4-dioxin  33857-26-0   *Dioxins. J Agr Food Chem 19(6):1210;1971

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