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ψ
ψ
ψ
Mesna
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Definition
: A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.
Pharmacological Action
Protective Agents
Other names
Coenzyme M; 2-
Mercaptoethanesulfonate; UCB3983; UCB 3983; Mesna Sanfer Brand; Mesna Kendrick Brand; MESNA cell; Bristol Myers Squibb Brand of Mesna; ASTAD 7093; ASTA D 7093; 2-
Mercaptoethanesulphonate, Sodium; 2 Mercaptoethanesulfonate; cell pharm Brand of Mesna; Ziken; Uromitexan; UCB-
3983; UCB Brand of Mesna; Sodium 2-
Mercaptoethanesulphonate; Sanfer Brand of Mesna; Mucofluid
Drugs
*
:
MESNEX
;
MESNA
Substance
CAS Registry & name
Categories
Source
Drugs
*
12-
aza-
13-
carboxy-
14-
hydroxy-
11-
oxo-
3,4-
dithiapentadecanesulfonic acid 14-
phosphate
0
*Phosphoric Acid Esters
Mesna/*analogs & derivatives.
Chembiochem 2003 Apr 4;4(4):333-5
TIC protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Ifosfamide
Carboplatin
Taxoids.
Semin Oncol 2000 Feb;27(1 Suppl 1):36-40
MINT protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Ifosfamide
Mitoxantrone
Taxoids.
Invest New Drugs 1999;17(2):187-92
NaPIM protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Ifosfamide
Vinblastine/analogs & derivatives.
Cancer Chemother Pharmacol 1999;44 Suppl;S24-5
VACIME protocol
0
Mesna
Doxorubicin
Ifosfamide
*Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Etoposide
Vincristine.
Bone Marrow Transplant 1999 Sep;24(5):527-33
2-
mercaptoethanesulfonic acid albumin
0
*Serum Albumin
Mesna/*analogs & derivatives.
Arzneimittelforschung 1998 Jun;48(6):691-3
VIMP protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Ifosfamide
Vincristine
Carboplatin.
J Clin Oncol 1998 Aug;16(8):2708-14
MIZE protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Etoposide
Ifosfamide
Idarubicin.
Leuk Lymphoma 1997 Aug;26(5-6):595-602
VIE protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Ifosfamide
Vincristine
Epirubicin.
Eur J Cancer 1995 Oct;31A(11):1773-7
MINE-
BOP protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Bleomycin
Etoposide
Ifosfamide
Mitoxantrone
Prednisone
Vincristine.
Acta Oncol 1995;34(7):937-40
MINE protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Etoposide
Ifosfamide
Mitoxantrone.
Invest New Drugs 1994;12(3):217-22
ICE protocol 5
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Etoposide
Ifosfamide
Carboplatin.
Hum Gene Ther 1994 Jul;5(7):891-911
IVADIC regimen
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Dacarbazine
Doxorubicin
Ifosfamide
Vincristine.
Cancer Chemother Pharmacol 1992;30(2):100-4
MINE-
ESHAP protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Cytarabine
Etoposide
Ifosfamide
Methylprednisolone Hemisuccinate
Mitoxantrone.
Ann Oncol 1991;2 (Suppl 1):31
MAID protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Dacarbazine
Doxorubicin
Ifosfamide.
J Clin Oncol 1989;7(9):1208
arginine 2-
mercaptoethane sulfonate
106854-46-0
Arginine/*analogs & derivatives
Mesna/*analogs & derivatives.
Drugs Exp Clin Res 1988;14(7):473
VlhP protocol
0
Mesna
*Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Etoposide
Ifosfamide.
Cancer 1988;62(1):24
2-
mercaptoethanesulfonate-
cysteine disulfide
0
Cysteine/*analogs & derivatives
Mesna/*analogs & derivatives.
Clin Chim Acta 1981;111(1):47
2,2'-
dithiodiethanesulfonic acid
45127-11-5 ethanesulfonic acid, 2,2'-
dithiobis
Mesna/*analogs & derivatives.
Anal Biochem 1980;106(2):363
acetylcoenzyme M
0
Mesna/*analogs & derivatives.
Anal Biochem 1980;106(2):363
methyl coenzyme M methylreductase
EC 1.-
*Oxidoreductases
Multienzyme Complexes
Mesna.
Appl Environ Microbiol 34(4):374;1977; Methods Enzymol 1980;67:545
methyl coenzyme M
53501-90-9 2-
(methylthio)ethanesulfonate
Mesna/*analogs & derivatives.
J Bacteriol 1980;141(2):728; J Biol Chem 1980;255(5):1891