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Cardiotonic Agents

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Definition: Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).  do not confuse with CARDIOTOXINS    Other names Myocardial Stimulants; Inotropic Agents, Positive Cardiac; Cardioprotective Agents; Cardiac Stimulants; Cardiotonic Drugs; Cardiotonics
Substances having this pharmacologic action: bufalin; ibopamine; toxin II (Anemonia sulcata); strophanthin K; sulmazole; denopamine; piroximone; pimobendan; vesnarinone; imazodan; 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone; Milrinone; pirbuterol; helenalin; Adrenomedullin; sanguinarine; simendan; gidazepam; propionylcarnitine; Amrinone; Phosphocreatine; Potassium Magnesium Aspartate; Digitalis Glycosides; Digitoxin; Prenalterol; Proscillaridin; Strophanthins; Enoximone; Lisinopril; Ouabain; Oxyfedrine; Medigoxin; Digoxin; Dobutamine; Dopamine; Acetyldigitoxins; Acetyldigoxins; Bufanolides; Cymarine; Carbachol; Etilefrine; Cardiac Glycosides; Isoproterenol; Phenylephrine; Aminophylline; Deslanoside; higenamine; 6-hydroxymelatonin; anthopleurin-A; plumbagin; torborinone; ICI D2788; BMS 180448; EMD 53998; BDF 9148; draflazine; CI 980; colforsin; arbutamine; tedisamil; bimakalim; olprinone; UD CG 212 Cl; 5-(4-acetamidophenyl)pyrazin-2(1H)-one; 1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-one; MCI 154; zatebradine; DPI 201-106
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
10-O-dimethylaminoethylginkgolide B  0   *Lactones *Ginkgolides Cardiotonic Agents. J Asian Nat Prod Res. 2012;14(1):27-38
3-(4-bromo-phenoxy)-4,5-dihydroxybenzoic acid-methyl ester  0   *Benzoates *Phenyl Ethers Cardiotonic Agents. Arch Pharm Res. 2011 Jul;34(7):1191-9
RC 552  0   *Glycolipids Cardiotonic Agents. Am J Physiol 1999 Dec;277(6 Pt 2):H2418-24
N-(4-cyanophenyl)-N'-cyano-N''-(3,4-dihydro-3-hydroxy-6-((N,N-diisobutylamino)sulfonyl)-2,2-dimethyl-2H-1-benzopyran-4-yl)guanidine  0   *Benzopyrans *Guanidines Cardiotonic Agents. J Med Chem 1999 Sep 9;42(18):3711-7
rutecarpine  84-26-4   *Quinazolines *Indole Alkaloids Cardiotonic Agents Platelet Aggregation Inhibitors Rutaceae.
Pharma Action Vasodilator Agents 		J Nat Prod 1980;43(5):577

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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